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Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging.
Vendrov AE, Lozhkin A, Hayami T, Levin J, Silveira Fernandes Chamon J, Abdel-Latif A, Runge MS, Madamanchi NR. Vendrov AE, et al. Among authors: madamanchi nr. Front Immunol. 2024 Jun 21;15:1410832. doi: 10.3389/fimmu.2024.1410832. eCollection 2024. Front Immunol. 2024. PMID: 38975335 Free PMC article.
Macrophages are pivotal in the pathogenesis of vascular aging, driving inflammation and atherosclerosis progression. NOX4 (NADPH oxidase 4) expression increases with age, correlating with mitochondrial dysfunction, inflammation, and atherosclerosis. .. …
Macrophages are pivotal in the pathogenesis of vascular aging, driving inflammation and atherosclerosis progression. NOX4 (NADPH oxid …
Mitochondrial dysfunction in atherosclerosis.
Madamanchi NR, Runge MS. Madamanchi NR, et al. Circ Res. 2007 Mar 2;100(4):460-73. doi: 10.1161/01.RES.0000258450.44413.96. Circ Res. 2007. PMID: 17332437 Free article. Review.
Moreover, major precursors of atherosclerosis-hypercholesterolemia, hyperglycemia, hypertriglyceridemia, and even the process of aging-all induce mitochondrial dysfunction. ...Mitochondrial function is required for normal vascular cell growth and funct …
Moreover, major precursors of atherosclerosis-hypercholesterolemia, hyperglycemia, hypertriglyceridemia, and even the process of agin …
Redox signaling in cardiovascular health and disease.
Madamanchi NR, Runge MS. Madamanchi NR, et al. Free Radic Biol Med. 2013 Aug;61:473-501. doi: 10.1016/j.freeradbiomed.2013.04.001. Epub 2013 Apr 11. Free Radic Biol Med. 2013. PMID: 23583330 Free PMC article. Review.
However, data from experimental and animal studies strongly support that dysregulated redox signaling, resulting from hyperactivation of various cellular oxidases or mitochondrial dysfunction, is integral to the pathogenesis and progression of cardiovascular disease …
However, data from experimental and animal studies strongly support that dysregulated redox signaling, resulting from hyperactivation of var …
Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes.
Madamanchi NR, Hakim ZS, Runge MS. Madamanchi NR, et al. J Thromb Haemost. 2005 Feb;3(2):254-67. doi: 10.1111/j.1538-7836.2004.01085.x. J Thromb Haemost. 2005. PMID: 15670030 Free article. Review.
Various animal models of atherosclerosis support the notion that ROS released from NAD(P)H oxidases, xanthine oxidase, lipoxygenases, and enhanced ROS production from dysfunctional mitochondrial respiratory chain indeed have a causatory role in atherosclerosis …
Various animal models of atherosclerosis support the notion that ROS released from NAD(P)H oxidases, xanthine oxidase, lipoxygenases, …
NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis.
Lozhkin A, Vendrov AE, Pan H, Wickline SA, Madamanchi NR, Runge MS. Lozhkin A, et al. Among authors: madamanchi nr. J Mol Cell Cardiol. 2017 Jan;102:10-21. doi: 10.1016/j.yjmcc.2016.12.004. Epub 2016 Dec 14. J Mol Cell Cardiol. 2017. PMID: 27986445 Free PMC article.
We recently reported that increased NADPH oxidase 4 (NOX4) expression and activity during aging results in enhanced cellular and mitochondrial oxidative stress, vascular inflammation, dysfunction, and atherosclerosis. The goal of the present study was to eluc …
We recently reported that increased NADPH oxidase 4 (NOX4) expression and activity during aging results in enhanced cellular and mitochon …
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease.
Vendrov AE, Vendrov KC, Smith A, Yuan J, Sumida A, Robidoux J, Runge MS, Madamanchi NR. Vendrov AE, et al. Among authors: madamanchi nr. Antioxid Redox Signal. 2015 Dec 20;23(18):1389-409. doi: 10.1089/ars.2014.6221. Epub 2015 Jul 14. Antioxid Redox Signal. 2015. PMID: 26054376 Free PMC article.
RESULTS: Both aged (16 months) Apoe(-/-) and Apoe(-/-)/p47phox(-/-) mice had increased atherosclerotic lesion area, aortic stiffness, and systolic dysfunction compared with young (4 months) cohorts. Cellular and mitochondrial ROS (mtROS) levels were significantly hi …
RESULTS: Both aged (16 months) Apoe(-/-) and Apoe(-/-)/p47phox(-/-) mice had increased atherosclerotic lesion area, aortic stiffness, and sy …
Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice.
Vendrov AE, Stevenson MD, Alahari S, Pan H, Wickline SA, Madamanchi NR, Runge MS. Vendrov AE, et al. Among authors: madamanchi nr. J Am Heart Assoc. 2017 Oct 27;6(11):e006775. doi: 10.1161/JAHA.117.006775. J Am Heart Assoc. 2017. PMID: 29079564 Free PMC article.
We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic compliance in aged wild-type mice and that young Apoe(-/-)/Sod2(+/-) had increased mitochondrial DNA damage and atherosclerosis versus young Apoe(-/-) …
We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic compliance in aged wild-t …