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Programmed cell senescence during mammalian embryonic development.
Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M. Muñoz-Espín D, et al. Cell. 2013 Nov 21;155(5):1104-18. doi: 10.1016/j.cell.2013.10.019. Epub 2013 Nov 14. Cell. 2013. PMID: 24238962 Free article.
Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer and aging. Here, we show that senescence occurs during mammalian embryonic development at multiple locations, including the mesonephros and the end …
Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer and aging. Here, we show that se …
A guide to assessing cellular senescence in vitro and in vivo.
González-Gualda E, Baker AG, Fruk L, Muñoz-Espín D. González-Gualda E, et al. Among authors: munoz espin d. FEBS J. 2021 Jan;288(1):56-80. doi: 10.1111/febs.15570. Epub 2020 Oct 10. FEBS J. 2021. PMID: 32961620 Free article. Review.
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. ...Here, we compile such advances and present a multifactorial guide to identify …
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arre …
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.
González-Gualda E, Reinius MAV, Macias D, Morsli S, Ge J, Olan I, Martín JE, Ou HL, Hartono M, Puerto-Camacho MP, Denholm M, Kieran R, Hoffmann R, Dane M, Veroutis D, Medrano G, Mulero F, Jimenez-Linan M, Fruk L, Martins CP, Barbacid M, Gorgoulis V, Korkola JE, Rassl DM, Doherty GJ, Rintoul RC, Narita M, Brenton JD, Muñoz-Espín D. González-Gualda E, et al. Among authors: munoz espin d. Nat Aging. 2026 Feb;6(2):368-392. doi: 10.1038/s43587-025-01054-2. Epub 2026 Feb 3. Nat Aging. 2026. PMID: 41634464 Free PMC article.
Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) and high-grade serous ovarian cancer (HGSOC) treatments, yet clinical outcomes remain poor. Cellular senescence and its associated secretory phenotype (SASP) can have multiple …
Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) and high-grade serous ovarian cancer (HGSOC) trea …
Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.
Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. Zhao Y, et al. Among authors: munoz espin d. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. doi: 10.1073/pnas.1721160115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432174 Free PMC article.
Cellular senescence also plays an important role in tissue remodeling during development. ...NMR cells also underwent cellular senescence when transfected with oncogenic Ras. In addition, cellular senescence was detected in NMR …
Cellular senescence also plays an important role in tissue remodeling during development. ...NMR cells also underwent …
Robust, universal biomarker assay to detect senescent cells in biological specimens.
Evangelou K, Lougiakis N, Rizou SV, Kotsinas A, Kletsas D, Muñoz-Espín D, Kastrinakis NG, Pouli N, Marakos P, Townsend P, Serrano M, Bartek J, Gorgoulis VG. Evangelou K, et al. Among authors: munoz espin d. Aging Cell. 2017 Feb;16(1):192-197. doi: 10.1111/acel.12545. Epub 2016 Nov 17. Aging Cell. 2017. PMID: 28165661 Free PMC article.
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. ...This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally appl …
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to dete …
In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.
Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG. Barbouti A, et al. Among authors: munoz espin d. Mech Ageing Dev. 2019 Jan;177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25. Mech Ageing Dev. 2019. PMID: 29490231
Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. ...Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular se …
Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and …