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Ageing as a risk factor for disease.
Niccoli T, Partridge L. Niccoli T, et al. Curr Biol. 2012 Sep 11;22(17):R741-52. doi: 10.1016/j.cub.2012.07.024. Curr Biol. 2012. PMID: 22975005 Free article. Review.
Age is the main risk factor for the prevalent diseases of developed countries: cancer, cardiovascular disease and neurodegeneration. ...Mitochondrial activity can also promote ageing, while genome maintenance and autophagy can protect against it …
Age is the main risk factor for the prevalent diseases of developed countries: cancer, cardiovascular disease an …
Ageing as a risk factor for ALS/FTD.
Niccoli T, Partridge L, Isaacs AM. Niccoli T, et al. Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113. doi: 10.1093/hmg/ddx247. Hum Mol Genet. 2017. PMID: 28977441 Review.
Like many other neurodegenerative diseases, age is a major risk factor in the development of ALS/FTD. But why is this the case? Recent genetic advances have highlighted some of pathways involved in the development of disease, and, strikingly, they appe …
Like many other neurodegenerative diseases, age is a major risk factor in the development of ALS/FTD. But why is this t …
PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.
Yu Y, Niccoli T, Ren Z, Woodling NS, Aleyakpo B, Szabadkai G, Partridge L. Yu Y, et al. Among authors: niccoli t. Hum Mol Genet. 2020 Aug 11;29(14):2420-2434. doi: 10.1093/hmg/ddaa125. Hum Mol Genet. 2020. PMID: 32592479 Free PMC article.
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. ...We also found that lap modulated the localization of amphiphysin (Amph), the homologue of another AD risk factor BIN1, and that Amph itsel …
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. ...We also foun …