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What do drug transporters really do?
Nigam SK. Nigam SK. Nat Rev Drug Discov. 2015 Jan;14(1):29-44. doi: 10.1038/nrd4461. Epub 2014 Dec 5. Nat Rev Drug Discov. 2015. PMID: 25475361 Free PMC article. Review.
Potential drug-drug interactions mediated by the ATP-binding cassette (ABC) transporter and solute carrier (SLC) transporter families are of clinical and regulatory concern. However, the endogenous functions of these drug transporters are …
Potential drug-drug interactions mediated by the ATP-binding cassette (ABC) transporter and solute carrier (SLC) tra
The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.
Nigam SK. Nigam SK. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687. doi: 10.1146/annurev-pharmtox-010617-052713. Annu Rev Pharmacol Toxicol. 2018. PMID: 29309257 Free PMC article. Review.
Evolutionary analysis indicates that SLC22 transporters fall into at least six subfamilies: OAT (organic anion transporter), OAT-like, OAT-related, OCT (organic cation transporter), OCTN (organic cation/carnitine transporter), and OCT/OCTN-related. Som …
Evolutionary analysis indicates that SLC22 transporters fall into at least six subfamilies: OAT (organic anion transporter), O …
The organic anion transporter (OAT) family: a systems biology perspective.
Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. Nigam SK, et al. Physiol Rev. 2015 Jan;95(1):83-123. doi: 10.1152/physrev.00025.2013. Physiol Rev. 2015. PMID: 25540139 Free PMC article. Review.
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroida …
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter fam …
Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.
Nigam SK, Bush KT. Nigam SK, et al. Nat Rev Nephrol. 2019 May;15(5):301-316. doi: 10.1038/s41581-019-0111-1. Nat Rev Nephrol. 2019. PMID: 30728454 Free PMC article. Review.
As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple biological pathways are affected, including those controlled by solute carrier (SLC) and ATP-binding cassette (ABC) transporters
As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple …
The systems biology of uric acid transporters: the role of remote sensing and signaling.
Nigam SK, Bhatnagar V. Nigam SK, et al. Curr Opin Nephrol Hypertens. 2018 Jul;27(4):305-313. doi: 10.1097/MNH.0000000000000427. Curr Opin Nephrol Hypertens. 2018. PMID: 29847376 Free PMC article. Review.
PURPOSE OF REVIEW: Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific 'drug' transporters (e.g., OAT1, OAT3, and ABCG2). ...Normally, SLC2A9, - along with URAT1, O …
PURPOSE OF REVIEW: Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, …
The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology.
Nigam SK, Bush KT, Bhatnagar V, Poloyac SM, Momper JD. Nigam SK, et al. Clin Pharmacol Ther. 2020 Jul;108(1):40-53. doi: 10.1002/cpt.1818. Epub 2020 Apr 11. Clin Pharmacol Ther. 2020. PMID: 32119114 Free PMC article. Review.
Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug discovery and development. It is now time to fully rethink the biological functions of drug metabolizing enzymes (DMEs) and transporters within the framework of QSP …
Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug discovery and development. It is now time to …
Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.
Nigam AK, Li JG, Lall K, Shi D, Bush KT, Bhatnagar V, Abagyan R, Nigam SK. Nigam AK, et al. Among authors: nigam sk. J Biol Chem. 2020 Feb 14;295(7):1829-1842. doi: 10.1074/jbc.RA119.010729. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896576 Free PMC article.
Together, the results suggest the potential molecular basis by which OAT1 and OAT3 modulate distinct metabolic and signaling pathways in vivo As suggested by the Remote Sensing and Signaling Theory, the analysis provides a potential mechanism by which "multispecific" kidney proxi …
Together, the results suggest the potential molecular basis by which OAT1 and OAT3 modulate distinct metabolic and signaling pathways in viv …
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues.
Nigam SK, Bush KT, Bhatnagar V. Nigam SK, et al. Nat Clin Pract Nephrol. 2007 Aug;3(8):443-8. doi: 10.1038/ncpneph0558. Nat Clin Pract Nephrol. 2007. PMID: 17653123 Review.
The prototype, OAT1 (SLC22A6), first identified as NKT in 1996, is the best-studied member of the OAT subgroup of the SLC22 transporter family, which also includes OCTs (organic cation transporters), OCTNs (organic cation transporters of carnitine) and Flipts …
The prototype, OAT1 (SLC22A6), first identified as NKT in 1996, is the best-studied member of the OAT subgroup of the SLC22 transporter
Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication.
Momper JD, Nigam SK. Momper JD, et al. Among authors: nigam sk. Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):561-570. doi: 10.1080/17425255.2018.1473376. Epub 2018 Jun 4. Expert Opin Drug Metab Toxicol. 2018. PMID: 29746174 Free PMC article. Review.
The ontogeny of drug transport and metabolism is generally studied independently in tissues, yet in the immediate postnatal period the developmental regulation of SLC and ABC transporters and metabolizing enzymes must be coordinated. Using the Remote Sensing …
The ontogeny of drug transport and metabolism is generally studied independently in tissues, yet in the immediate postnatal pe …
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN; Pediatric Transporter Working Group. Brouwer KL, et al. Among authors: nigam sk. Clin Pharmacol Ther. 2015 Sep;98(3):266-87. doi: 10.1002/cpt.176. Clin Pharmacol Ther. 2015. PMID: 26088472 Free PMC article. Review.
The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic r …
The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about d
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