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Age, neuropathology, and dementia.
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C; Medical Research Council Cognitive Function and Ageing Study. Savva GM, et al. N Engl J Med. 2009 May 28;360(22):2302-9. doi: 10.1056/NEJMoa0806142. N Engl J Med. 2009. PMID: 19474427 Free article.
Logistic regression was used to estimate the effect of age on the relationship between neuropathological features and dementia. RESULTS: The difference in the prevalence of moderate and severe Alzheimer's-type pathological changes between persons with and those with …
Logistic regression was used to estimate the effect of age on the relationship between neuropathological features and dementia …
Frailty and cognitive impairment--a review of the evidence and causal mechanisms.
Robertson DA, Savva GM, Kenny RA. Robertson DA, et al. Among authors: savva gm. Ageing Res Rev. 2013 Sep;12(4):840-51. doi: 10.1016/j.arr.2013.06.004. Epub 2013 Jul 4. Ageing Res Rev. 2013. PMID: 23831959 Review.
Incidence rates of cognitive impairment and dementia are rising with the ageing population. Meanwhile, the limited success of current treatments has led to a search for early markers of dementia which could predict future progression or improve quality of life for t …
Incidence rates of cognitive impairment and dementia are rising with the ageing population. Meanwhile, the limited success of current …
Stage-specific changes in neurogenic and glial markers in Alzheimer's disease.
Ekonomou A, Savva GM, Brayne C, Forster G, Francis PT, Johnson M, Perry EK, Attems J, Somani A, Minger SL, Ballard CG; Medical Research Council Cognitive Function and Ageing Neuropathology Study. Ekonomou A, et al. Among authors: savva gm. Biol Psychiatry. 2015 Apr 15;77(8):711-9. doi: 10.1016/j.biopsych.2014.05.021. Epub 2014 Jun 9. Biol Psychiatry. 2015. PMID: 25022604
We examined endogenous neurogenesis and glia changes across the range of pathologic severity of AD in people with and without dementia to address this key question. METHODS: Endogenous neurogenesis and glia in the subventricular zone and dentate gyrus neurogenic niches wer …
We examined endogenous neurogenesis and glia changes across the range of pathologic severity of AD in people with and without dementia …
Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.
Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG; Medical Research Council Cognitive Function and Aging Study. Wharton SB, et al. Among authors: savva gm. J Alzheimers Dis. 2011;25(2):359-72. doi: 10.3233/JAD-2011-091402. J Alzheimers Dis. 2011. PMID: 21422529
This resource enables a thorough epidemiological description of the neuropathology associated with dementia in the UK. Results to date reveal a high prevalence of mixed Alzheimer and vascular pathology, a significant population who die with dementia but with …
This resource enables a thorough epidemiological description of the neuropathology associated with dementia in the UK. Results …
Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.
Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB. Lace G, et al. Among authors: savva gm. Dement Geriatr Cogn Disord. 2012;34(1):15-24. doi: 10.1159/000341581. Epub 2012 Aug 3. Dement Geriatr Cogn Disord. 2012. PMID: 22868294
TSA in grey matter were associated with coiled bodies (p = 0.011) and argyrophilic grains (p = 0.048), which were identified in 11.5% of cases. They did not correlate with dementia. CONCLUSIONS: Astrocyte tau pathology is common in the ageing mesial temporal lobe. ...It is …
TSA in grey matter were associated with coiled bodies (p = 0.011) and argyrophilic grains (p = 0.048), which were identified in 11.5% of cas …