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Genetic signatures of exceptional longevity in humans.
Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Sebastiani P, et al. PLoS One. 2012;7(1):e29848. doi: 10.1371/journal.pone.0029848. Epub 2012 Jan 18. PLoS One. 2012. PMID: 22279548 Free PMC article.
To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians (median age at death 104 years) and 914 genetically matched healthy controls. ...The different signatures may help dis …
To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 cente …
RETRACTED: Genetic signatures of exceptional longevity in humans.
Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Sebastiani P, et al. Science. 2010 Jul 1;2010. doi: 10.1126/science.1190532. Epub 2010 Jul 1. Science. 2010. Retraction in: Science. 2011 Jul 22;333(6041):404. doi: 10.1126/science.333.6041.404-a. PMID: 20595579 Retracted.
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centena …
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explo …
Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.
Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Karagiannis TT, et al. Among authors: sebastiani p. EBioMedicine. 2023 Apr;90:104514. doi: 10.1016/j.ebiom.2023.104514. Epub 2023 Mar 31. EBioMedicine. 2023. PMID: 37005201 Free PMC article.
Our transcriptional analysis identified cell type signatures specific to exceptional longevity that included genes with age-related changes (e.g., increased expression of STK17A, a gene known to be involved in DNA damage response) as well as genes expressed u …
Our transcriptional analysis identified cell type signatures specific to exceptional longevity that included genes with …
Meta-analysis of genetic variants associated with human exceptional longevity.
Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Sebastiani P, et al. Aging (Albany NY). 2013 Sep;5(9):653-61. doi: 10.18632/aging.100594. Aging (Albany NY). 2013. PMID: 24244950 Free PMC article.
Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. ...This would support our hypothesis that the genetic influence upon …
Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively fe …