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1998 1
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2001 5
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2005 3
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2007 3
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2019 2
2021 0
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Page 1
Hypoxia-inducible factor 1 and cardiovascular disease.
Semenza GL. Semenza GL. Annu Rev Physiol. 2014;76:39-56. doi: 10.1146/annurev-physiol-021113-170322. Epub 2013 Aug 21. Annu Rev Physiol. 2014. PMID: 23988176 Free PMC article. Review.
However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan …
However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible fac
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology.
Semenza GL. Semenza GL. Annu Rev Pathol. 2014;9:47-71. doi: 10.1146/annurev-pathol-012513-104720. Epub 2013 Aug 7. Annu Rev Pathol. 2014. PMID: 23937437 Review.
Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by
Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, whic
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Prabhakar NR, Semenza GL. Prabhakar NR, et al. Among authors: semenza gl. Physiol Rev. 2012 Jul;92(3):967-1003. doi: 10.1152/physrev.00030.2011. Physiol Rev. 2012. PMID: 22811423 Free PMC article. Review.
The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the HIF family of transcriptional activators has provided insight into the molecular underpinnings of oxygen homeostasis. ...HIF-1 and H …
The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members of the …
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. Dabral S, et al. Among authors: semenza gl. Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z. Nat Commun. 2019. PMID: 31086178 Free PMC article.
Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. ...In parallel, hypoxia inducible factor-1 alpha (HIF-1alpha) activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter r
Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. ...In parallel, hypoxia
HIF-1α is required for development of the sympathetic nervous system.
Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Görlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G. Bohuslavova R, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13414-13423. doi: 10.1073/pnas.1903510116. Epub 2019 Jun 13. Proc Natl Acad Sci U S A. 2019. PMID: 31196952 Free PMC article.
We generated mice in which conditional knockout (CKO) of the Hif1a gene encoding the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is mediated by an Islet1-Cre transgene expressed in the cardiac outflow tract, right ventricle and at …
We generated mice in which conditional knockout (CKO) of the Hif1a gene encoding the transcription factor hypoxia-inducible
Oxygen sensing, homeostasis, and disease.
Semenza GL. Semenza GL. N Engl J Med. 2011 Aug 11;365(6):537-47. doi: 10.1056/NEJMra1011165. N Engl J Med. 2011. PMID: 21830968 Review. No abstract available.
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.
Semenza GL. Semenza GL. Trends Mol Med. 2001 Aug;7(8):345-50. doi: 10.1016/s1471-4914(01)02090-1. Trends Mol Med. 2001. PMID: 11516994 Review.
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. ...Modulation of HIF-1 activity by genetic or pharmacological means could provide a nove
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adapti
Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease.
Semenza GL. Semenza GL. Pediatr Res. 2001 May;49(5):614-7. doi: 10.1203/00006450-200105000-00002. Pediatr Res. 2001. PMID: 11328942 Review.
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations. HIF-1 is a heterodimer consisting of an oxygen-regulated HIF-1 alp
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expressio
Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.
Semenza GL, Agani F, Iyer N, Kotch L, Laughner E, Leung S, Yu A. Semenza GL, et al. Ann N Y Acad Sci. 1999 Jun 30;874:262-8. doi: 10.1111/j.1749-6632.1999.tb09241.x. Ann N Y Acad Sci. 1999. PMID: 10415537 Review.
Hypoxia is an essential pathophysiologic component of ischemic cardiovascular disease. A better understanding of the molecular mechanisms underlying adaptive responses to hypoxia may lead to novel therapeutic strategies. Hypoxia-inducible
Hypoxia is an essential pathophysiologic component of ischemic cardiovascular disease. A better understanding of the mo
HIF-1: mediator of physiological and pathophysiological responses to hypoxia.
Semenza GL. Semenza GL. J Appl Physiol (1985). 2000 Apr;88(4):1474-80. doi: 10.1152/jappl.2000.88.4.1474. J Appl Physiol (1985). 2000. PMID: 10749844 Free article. Review.
The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O(2) homeostasis. ...HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lu …
The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O(2) homeost …
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