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Parkin and PINK1 mitigate STING-induced inflammation.
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Sliter DA, et al. Nature. 2018 Sep;561(7722):258-262. doi: 10.1038/s41586-018-0448-9. Epub 2018 Aug 22. Nature. 2018. Retraction in: Nature. 2025 Aug;644(8078):1116. doi: 10.1038/s41586-025-09346-8. PMID: 30135585 Free PMC article. Retracted.
The in vivo role of mitophagy, however, is unclear, partly because mice that lack either PINK1 or parkin have no substantial Parkinson's-disease-relevant phenotypes(5-7). Mitochondrial stress can lead to the release of damage-associated molecular patterns (DAMPs) th …
The in vivo role of mitophagy, however, is unclear, partly because mice that lack either PINK1 or parkin have no substantial P …
Retraction Note: Parkin and PINK1 mitigate STING-induced inflammation.
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Sliter DA, et al. Nature. 2025 Aug;644(8078):1116. doi: 10.1038/s41586-025-09346-8. Nature. 2025. PMID: 40739362 No abstract available.