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Measuring In Vivo Mitophagy.
Sun N, Yun J, Liu J, Malide D, Liu C, Rovira II, Holmström KM, Fergusson MM, Yoo YH, Combs CA, Finkel T. Sun N, et al. Mol Cell. 2015 Nov 19;60(4):685-96. doi: 10.1016/j.molcel.2015.10.009. Epub 2015 Nov 5. Mol Cell. 2015. PMID: 26549682 Free PMC article.
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. ...The ability to assess mitophagy under a host of varying environmental and geneti …
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods t …
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.
Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. Fang EF, et al. Among authors: sun n. J Vis Exp. 2017 Nov 22;(129):56301. doi: 10.3791/56301. J Vis Exp. 2017. PMID: 29286376 Free PMC article.
Recent progress towards the understanding of the molecular mechanisms of mitophagy has enabled the development of novel mitophagy detection techniques. Here, we introduce several versatile techniques to monitor mitophagy in human cells, Caenorhabditis elegans …
Recent progress towards the understanding of the molecular mechanisms of mitophagy has enabled the development of novel mitophagy …
A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima.
Sun N, Malide D, Liu J, Rovira II, Combs CA, Finkel T. Sun N, et al. Nat Protoc. 2017 Aug;12(8):1576-1587. doi: 10.1038/nprot.2017.060. Epub 2017 Jul 13. Nat Protoc. 2017. PMID: 28703790
Mitophagy is a cellular process that selectively removes damaged, old or dysfunctional mitochondria. ...Previous methods used to detect mitophagy in vivo were cumbersome, insensitive and difficult to quantify. We created a transgenic mouse model that e …
Mitophagy is a cellular process that selectively removes damaged, old or dysfunctional mitochondria. ...Previous methods used to dete …
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Luo H, Krigman J, Zhang R, Yang M, Sun N. Luo H, et al. Among authors: sun n. Acta Physiol (Oxf). 2021 Jul;232(3):e13666. doi: 10.1111/apha.13666. Epub 2021 Apr 29. Acta Physiol (Oxf). 2021. PMID: 33890401 Free PMC article.
In contrast, the reverse phenomenon, deubiquitination, removes ubiquitin from Parkin substrates embedded in the OMM proteins, antagonizing mitophagy. Recent evidence suggests that the mitochondrial deubiquitinase USP30 negatively regulates Parkin-mediated mitophagy, …
In contrast, the reverse phenomenon, deubiquitination, removes ubiquitin from Parkin substrates embedded in the OMM proteins, antagonizing …