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Measuring In Vivo Mitophagy.
Sun N, Yun J, Liu J, Malide D, Liu C, Rovira II, Holmström KM, Fergusson MM, Yoo YH, Combs CA, Finkel T. Sun N, et al. Mol Cell. 2015 Nov 19;60(4):685-96. doi: 10.1016/j.molcel.2015.10.009. Epub 2015 Nov 5. Mol Cell. 2015. PMID: 26549682 Free PMC article.
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of …
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods t …
A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima.
Sun N, Malide D, Liu J, Rovira II, Combs CA, Finkel T. Sun N, et al. Nat Protoc. 2017 Aug;12(8):1576-1587. doi: 10.1038/nprot.2017.060. Epub 2017 Jul 13. Nat Protoc. 2017. PMID: 28703790
Mitophagy is a cellular process that selectively removes damaged, old or dysfunctional mitochondria. ...Previous methods used to detect mitophagy in vivo were cumbersome, insensitive and difficult to quantify. ...
Mitophagy is a cellular process that selectively removes damaged, old or dysfunctional mitochondria. ...Previous methods used to dete
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.
Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. Fang EF, et al. Among authors: sun n. J Vis Exp. 2017 Nov 22;(129):56301. doi: 10.3791/56301. J Vis Exp. 2017. PMID: 29286376 Free PMC article.
Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging syndromes, and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Maintenance of mitochondr …
Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging synd …
Pharmacological inhibition of USP30 activates tissue-specific mitophagy.
Luo H, Krigman J, Zhang R, Yang M, Sun N. Luo H, et al. Among authors: sun n. Acta Physiol (Oxf). 2021 Jul;232(3):e13666. doi: 10.1111/apha.13666. Epub 2021 Apr 29. Acta Physiol (Oxf). 2021. PMID: 33890401 Free PMC article.
This process is an essential element of mitochondrial quality control, and dysregulation of mitophagy may contribute to a host of diseases, most notably neurodegenerative conditions such as Parkinson's disease. ...Here we will characterize a USP30 inhibitor and demo …
This process is an essential element of mitochondrial quality control, and dysregulation of mitophagy may contribute to a host of dis …