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Year Number of Results
2013 1
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Page 1
Senolytic drugs: from discovery to translation.
Kirkland JL, Tchkonia T. Kirkland JL, et al. Among authors: tchkonia t. J Intern Med. 2020 Nov;288(5):518-536. doi: 10.1111/joim.13141. Epub 2020 Aug 4. J Intern Med. 2020. PMID: 32686219 Free PMC article. Review.
SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality and health expenditures. ...Early pilot trials of senolytics suggest they decrease senescent cells, reduce inflammation an …
SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, …
Cellular Senescence: A Translational Perspective.
Kirkland JL, Tchkonia T. Kirkland JL, et al. Among authors: tchkonia t. EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12. EBioMedicine. 2017. PMID: 28416161 Free PMC article. Review.
The SASP can contribute to senescence-related inflammation, metabolic dysregulation, stem cell dysfunction, aging phenotypes, chronic diseases, geriatric syndromes, and loss of resilience. Delaying senescent cell accumulation or reducing …
The SASP can contribute to senescence-related inflammation, metabolic dysregulation, stem cell dysfunction, aging pheno …
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Tchkonia T, et al. J Clin Invest. 2013 Mar;123(3):966-72. doi: 10.1172/JCI64098. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454759 Free PMC article. Review.
One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secretory phenotype (SASP). We review the mechanisms that induce senescence and the SASP, their associations with chronic …
One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associate …
The role of cellular senescence in ageing and endocrine disease.
Khosla S, Farr JN, Tchkonia T, Kirkland JL. Khosla S, et al. Among authors: tchkonia t. Nat Rev Endocrinol. 2020 May;16(5):263-275. doi: 10.1038/s41574-020-0335-y. Epub 2020 Mar 11. Nat Rev Endocrinol. 2020. PMID: 32161396 Free PMC article. Review.
Here we review mechanisms of cellular senescence and approaches to target this pathway therapeutically using 'senolytic' drugs that kill senescent cells or inhibitors of the senescence-associated secretory phenotype (SASP). Furthermore, we highlight th …
Here we review mechanisms of cellular senescence and approaches to target this pathway therapeutically using 'senolytic' drugs …
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.
Suda M, Paul KH, Tripathi U, Minamino T, Tchkonia T, Kirkland JL. Suda M, et al. Among authors: tchkonia t. Endocr Rev. 2024 Sep 12;45(5):655-675. doi: 10.1210/endrev/bnae010. Endocr Rev. 2024. PMID: 38500373 Free PMC article. Review.
A better understanding of responsible underling biological mechanisms could help in the management of multiple endocrine disorders over and above hormone replacement therapy (HRT). Cellular senescence is involved in multiple biological aging processes and pat …
A better understanding of responsible underling biological mechanisms could help in the management of multiple endocrine disorders over and …
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: tchkonia t. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
BACKGROUND: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. ...Senescence, Frailty, …
BACKGROUND: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secr …
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.
Tavenier J, Nehlin JO, Houlind MB, Rasmussen LJ, Tchkonia T, Kirkland JL, Andersen O, Rasmussen LJH. Tavenier J, et al. Among authors: tchkonia t. Mech Ageing Dev. 2024 Dec;222:111995. doi: 10.1016/j.mad.2024.111995. Epub 2024 Oct 9. Mech Ageing Dev. 2024. PMID: 39384074 Free article. Review.
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic agent for the treatment of age-related chronic diseases. Senotherapeutics target senescent cells, which accumulate w …
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senoth …
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease.
Zhao Y, Zhu XY, Ma W, Zhang Y, Yuan F, Kim SR, Tang H, Jordan K, Lerman A, Tchkonia T, Kirkland JL, Lerman LO. Zhao Y, et al. Among authors: tchkonia t. Cell Death Dis. 2025 May 10;16(1):372. doi: 10.1038/s41419-025-07666-1. Cell Death Dis. 2025. PMID: 40348745 Free PMC article.
Cellular senescence participates in the pathophysiology of post-stenotic kidney damage, but how it regulates tissue remodeling is incompletely understood. ...Renal perfusion was studied in vivo using micro-MRI, and kidney morphology, senescence, and MMT ex vi …
Cellular senescence participates in the pathophysiology of post-stenotic kidney damage, but how it regulates tissue remodeling …
Reducing Senescent Cell Burden in Aging and Disease.
Pignolo RJ, Passos JF, Khosla S, Tchkonia T, Kirkland JL. Pignolo RJ, et al. Among authors: tchkonia t. Trends Mol Med. 2020 Jul;26(7):630-638. doi: 10.1016/j.molmed.2020.03.005. Epub 2020 Apr 17. Trends Mol Med. 2020. PMID: 32589933 Free PMC article. Review.
Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alteratio …
Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arr …
Cellular Senescence and the Biology of Aging, Disease, and Frailty.
LeBrasseur NK, Tchkonia T, Kirkland JL. LeBrasseur NK, et al. Among authors: tchkonia t. Nestle Nutr Inst Workshop Ser. 2015;83:11-8. doi: 10.1159/000382054. Epub 2015 Oct 20. Nestle Nutr Inst Workshop Ser. 2015. PMID: 26485647 Free PMC article. Review.
There is now considerable evidence that cellular senescence is an underlying mechanism of aging and age-related conditions. Cellular senescence is a process in which cells lose the ability to divide and damage neighboring cells by the factors th …
There is now considerable evidence that cellular senescence is an underlying mechanism of aging and age-related conditi …
40 results