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Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging.
Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT. Terman A, et al. Antioxid Redox Signal. 2010 Apr;12(4):503-35. doi: 10.1089/ars.2009.2598. Antioxid Redox Signal. 2010. PMID: 19650712 Free PMC article. Review.
It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular damage by mitochondrially produced reactive oxygen species, mostly affecting long-lived postmitotic cells, such …
It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular …
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.
Terman A, Gustafsson B, Brunk UT. Terman A, et al. Chem Biol Interact. 2006 Oct 27;163(1-2):29-37. doi: 10.1016/j.cbi.2006.04.013. Epub 2006 May 1. Chem Biol Interact. 2006. PMID: 16737690 Review.
Aging mainly affects long-lived postmitotic cells, such as neurons and cardiac myocytes, which neither divide and dilute damaged structures, nor are replaced by newly differentiated cells. ...Based on findings that autophagy is diminished …
Aging mainly affects long-lived postmitotic cells, such as neurons and cardiac myocytes, which neither di …
Catabolic insufficiency and aging.
Terman A. Terman A. Ann N Y Acad Sci. 2006 May;1067:27-36. doi: 10.1196/annals.1354.005. Ann N Y Acad Sci. 2006. PMID: 16803967 Review.
Heavy lipofuscin loading of lysosomes, typical of old age, seems to pronouncedly decrease autophagic potential. As postulated in the mitochondrial-lysosomal axis theory of aging, this occurs on account of the transport of newly synthesized lysos …
Heavy lipofuscin loading of lysosomes, typical of old age, seems to pronouncedly decrease autophagic potential. As postulated in the mito …
Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover.
Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT. Terman A, et al. Ann N Y Acad Sci. 2004 Jun;1019:70-7. doi: 10.1196/annals.1297.015. Ann N Y Acad Sci. 2004. PMID: 15246997
Oxidative stress is believed to be an important contributor to aging, mainly affecting long-lived postmitotic cells such as cardiac myocytes and neurons. ...This assumption is based on our observation that pharmacological inhibition of autophagy …
Oxidative stress is believed to be an important contributor to aging, mainly affecting long-lived postmitotic …