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Page 1
Updated functional classification of beta-lactamases.
Bush K, Jacoby GA. Bush K, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):969-76. doi: 10.1128/AAC.01009-09. Epub 2009 Dec 7. Antimicrob Agents Chemother. 2010. PMID: 19995920 Free PMC article. Review.
Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam h …
Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on th …
Carbapenemases: the versatile beta-lactamases.
Queenan AM, Bush K. Queenan AM, et al. Clin Microbiol Rev. 2007 Jul;20(3):440-58, table of contents. doi: 10.1128/CMR.00001-07. Clin Microbiol Rev. 2007. PMID: 17630334 Free PMC article. Review.
Carbapenemases are members of the molecular class A, B, and D beta-lactamases. Class A and D enzymes have a serine-based hydrolytic mechanism, while class B enzymes are metallo-beta-lactamases that contain zinc in the active site. ...The class D carbap …
Carbapenemases are members of the molecular class A, B, and D beta-lactamases. Class A and D enzymes have a serine-based hydro …
Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance.
Davin-Regli A, Lavigne JP, Pagès JM. Davin-Regli A, et al. Clin Microbiol Rev. 2019 Jul 17;32(4):e00002-19. doi: 10.1128/CMR.00002-19. Print 2019 Sep 18. Clin Microbiol Rev. 2019. PMID: 31315895 Free PMC article. Review.
In the face of antibiotic treatment, it is able to manage different mechanisms of resistance via various local and global regulator genes and the modulation of the expression of different proteins, including enzymes (beta-lactamases, etc.) or membrane transporters, …
In the face of antibiotic treatment, it is able to manage different mechanisms of resistance via various local and global regulator genes an …
Classification of beta-lactamases.
Bauernfeind A. Bauernfeind A. Rev Infect Dis. 1986 Nov-Dec;8 Suppl 5:S470-81. Rev Infect Dis. 1986. PMID: 3541132 Review.
Traditionally, the classification of beta-lactamases has followed the general principles of describing enzymes by the characterization of their activity against substrates. ...Biophysical characterization, i.e., primarily isoelectric focusing, has greatly imp …
Traditionally, the classification of beta-lactamases has followed the general principles of describing enzymes by the c …
Update on the epidemiology of carbapenemases in Latin America and the Caribbean.
García-Betancur JC, Appel TM, Esparza G, Gales AC, Levy-Hara G, Cornistein W, Vega S, Nuñez D, Cuellar L, Bavestrello L, Castañeda-Méndez PF, Villalobos-Vindas JM, Villegas MV. García-Betancur JC, et al. Expert Rev Anti Infect Ther. 2021 Feb;19(2):197-213. doi: 10.1080/14787210.2020.1813023. Epub 2020 Sep 11. Expert Rev Anti Infect Ther. 2021. PMID: 32813566 Review.
INTRODUCTION: Carbapenemases are beta-lactamases able to hydrolyze a wide range of beta-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression …
INTRODUCTION: Carbapenemases are beta-lactamases able to hydrolyze a wide range of beta-lactam antibiotics, including c …
An updated phylogeny of the metallo-beta-lactamases.
Berglund F, Johnning A, Larsson DGJ, Kristiansson E. Berglund F, et al. J Antimicrob Chemother. 2021 Jan 1;76(1):117-123. doi: 10.1093/jac/dkaa392. J Antimicrob Chemother. 2021. PMID: 33005957
BACKGROUND: Metallo-beta-lactamases (MBLs) are enzymes that use zinc-dependent hydrolysis to confer resistance to almost all available beta-lactam antibiotics. ...Additionally, we identified three new variants of the zinc binding sites, indicating that the …
BACKGROUND: Metallo-beta-lactamases (MBLs) are enzymes that use zinc-dependent hydrolysis to confer resistance to almost all a …
Diversity, functional classification and genotyping of SHV beta-lactamases in Klebsiella pneumoniae.
Tsang KK, Lam MMC, Wick RR, Wyres KL, Bachman M, Baker S, Barry K, Brisse S, Campino S, Chiaverini A, Cirillo DM, Clark T, Corander J, Corbella M, Cornacchia A, Cuénod A, D'Alterio N, Di Marco F, Donado-Godoy P, Egli A, Farzana R, Feil EJ, Fostervold A, Gorrie CL, Hassan B, Hetland MAK, Hoa LNM, Hoi LT, Howden B, Ikhimiukor OO, Jenney AWJ, Kaspersen H, Khokhar F, Leangapichart T, Ligowska-Marzęta M, Löhr IH, Long SW, Mathers AJ, McArthur AG, Nagaraj G, Oaikhena AO, Okeke IN, Perdigão J, Parikh H, Pham MH, Pomilio F, Raffelsberger N, Rakotondrasoa A, Kumar KLR, Roberts LW, Rodrigues C, Samuelsen Ø, Sands K, Sassera D, Seth-Smith H, Shamanna V, Sherry NL, Sia S, Spadar A, Stoesser N, Sunde M, Sundsfjord A, Thach PN, Thomson NR, Thorpe HA, Torok ME, Trang VD, Trung NV, Vornhagen J, Walsh T, Warne B, Wilson H, Wright GD, Holt KE, KlebNET-Gsp Amr Genotype-Phenotype Group. Tsang KK, et al. Microb Genom. 2024 Oct;10(10):001294. doi: 10.1099/mgen.0.001294. Microb Genom. 2024. PMID: 39432416 Free PMC article.
Here, we reviewed the experimental evidence for the expansion of SHV enzyme function associated with specific aa substitutions. We then systematically assigned SHV alleles to functional classes (WT, ESBL and BLI resistant) based on the presence of these mutations. . …
Here, we reviewed the experimental evidence for the expansion of SHV enzyme function associated with specific aa substitutions. We th …
Class D beta-lactamases.
Yoon EJ, Jeong SH. Yoon EJ, et al. J Antimicrob Chemother. 2021 Mar 12;76(4):836-864. doi: 10.1093/jac/dkaa513. J Antimicrob Chemother. 2021. PMID: 33382875 Review.
Class D beta-lactamases are composed of 14 families and the majority of the member enzymes are included in the OXA family. ...The most dominant OXA family among class D beta-lactamases is superheterogeneous and the family needs to have an updated …
Class D beta-lactamases are composed of 14 families and the majority of the member enzymes are included in the OXA family. ... …
Structure-based classification of class A beta-lactamases, an update.
Philippon A, Jacquier H, Ruppé E, Labia R. Philippon A, et al. Curr Res Transl Med. 2019 Nov;67(4):115-122. doi: 10.1016/j.retram.2019.05.003. Epub 2019 May 31. Curr Res Transl Med. 2019. PMID: 31155436 Review.
The continual rapid development of genomic approaches and tremendous progress in automatic sequencer technology have resulted in the accumulation of massive amounts of data. A structure-based classification of class A beta-lactamases based on specific conserv …
The continual rapid development of genomic approaches and tremendous progress in automatic sequencer technology have resulted in the accumul …
The epidemiology of carbapenemases in Latin America and the Caribbean.
Escandón-Vargas K, Reyes S, Gutiérrez S, Villegas MV. Escandón-Vargas K, et al. Expert Rev Anti Infect Ther. 2017 Mar;15(3):277-297. doi: 10.1080/14787210.2017.1268918. Epub 2016 Dec 20. Expert Rev Anti Infect Ther. 2017. PMID: 27915487 Review.
Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. infections are major causes of morbidity and mortality, especially due to the emergence and spread of beta-lactamases. Carbapenemases, which are beta-lactamases with the capacity to hydrolyze …
Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp. infections are major causes of morbidity and mortality, especially due to the e …
46 results