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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Wiley CD, et al. Cell Metab. 2016 Feb 9;23(2):303-14. doi: 10.1016/j.cmet.2015.11.011. Epub 2015 Dec 10. Cell Metab. 2016. PMID: 26686024 Free PMC article.
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). ...Our data identify a distinct senescence response and provide a mechanism by which mit …
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secr …
Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.
Kuehnemann C, Hughes JB, Desprez PY, Melov S, Wiley CD, Campisi J. Kuehnemann C, et al. Among authors: wiley cd. Aging Cell. 2023 Jan;22(1):e13750. doi: 10.1111/acel.13750. Epub 2022 Dec 20. Aging Cell. 2023. PMID: 36539941 Free PMC article.
One commonality between mitochondrial dysfunction (induced by NRTIs) and defects in lamin A (induced by PIs) is they can cause or accelerate cellular senescence, a state of essentially irreversible growth arrest, and the secretion of many bioact …
One commonality between mitochondrial dysfunction (induced by NRTIs) and defects in lamin A (induced by PIs) is …