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Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis.
Wong YC, Ysselstein D, Krainc D. Wong YC, et al. Nature. 2018 Feb 15;554(7692):382-386. doi: 10.1038/nature25486. Epub 2018 Jan 24. Nature. 2018. PMID: 29364868 Free PMC article.
Here we have identified the formation and regulation of mitochondria-lysosome membrane contact sites using electron microscopy, structured illumination microscopy and high spatial and temporal resolution confocal live cell imaging. ... …
Here we have identified the formation and regulation of mitochondria-lysosome membrane contact sites …
Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases.
Cisneros J, Belton TB, Shum GC, Molakal CG, Wong YC. Cisneros J, et al. Among authors: wong yc. Trends Neurosci. 2022 Apr;45(4):312-322. doi: 10.1016/j.tins.2022.01.005. Trends Neurosci. 2022. PMID: 35249745 Free PMC article. Review.
Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contac …
Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediati …
Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1.
Peng W, Wong YC, Krainc D. Peng W, et al. Among authors: wong yc. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19266-19275. doi: 10.1073/pnas.2003236117. Epub 2020 Jul 23. Proc Natl Acad Sci U S A. 2020. PMID: 32703809 Free PMC article.
However, whether mitochondria-lysosome contacts serve additional functions by facilitating the direct transfer of metabolites or ions between the two organelles has not been elucidated. ...Lysosomal calcium release by TRPML1 promotes calcium transfer t …
However, whether mitochondria-lysosome contacts serve additional functions by facilitating the direct transfer o …
Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics.
Wong YC, Kim S, Cisneros J, Molakal CG, Song P, Lubbe SJ, Krainc D. Wong YC, et al. J Cell Biol. 2022 Oct 3;221(10):e202206140. doi: 10.1083/jcb.202206140. Epub 2022 Sep 1. J Cell Biol. 2022. PMID: 36044022 Free PMC article.
In contrast, dominant optic atrophy-linked mutant Mid51, which does not inhibit Mid51/Fis1 coupled oligomerization, does not disrupt downstream lysosomal dynamics. As Fis1 conversely also regulates Mid51 oligomerization, our work further highlights an oligomeric Mid51/Fis1 …
In contrast, dominant optic atrophy-linked mutant Mid51, which does not inhibit Mid51/Fis1 coupled oligomerization, does not disrupt downstr …
Live cell microscopy of mitochondria-lysosome contact site formation and tethering dynamics.
Belton TB, Leisten ED, Cisneros J, Wong YC. Belton TB, et al. Among authors: wong yc. STAR Protoc. 2022 Mar 18;3(2):101262. doi: 10.1016/j.xpro.2022.101262. eCollection 2022 Jun 17. STAR Protoc. 2022. PMID: 35330964 Free PMC article.
Mitochondria-lysosome contact sites are critical for maintaining cellular homeostasis by regulating mitochondrial and lysosomal network dynamics and mediating metabolite exchange. ...Although this protocol focuses on mammalian HeLa …
Mitochondria-lysosome contact sites are critical for maintaining cellular homeostasis by regula …
Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis.
Wong YC, Kim S, Peng W, Krainc D. Wong YC, et al. Trends Cell Biol. 2019 Jun;29(6):500-513. doi: 10.1016/j.tcb.2019.02.004. Epub 2019 Mar 18. Trends Cell Biol. 2019. PMID: 30898429 Free PMC article. Review.
Mitochondria-lysosome contact site tethering is mechanistically regulated by mitochondrial proteins promoting Rab7 GTP hydrolysis, and allows for the bidirectional crosstalk between mitochondria and lysosomes and the regulation of their organell …
Mitochondria-lysosome contact site tethering is mechanistically regulated by mitochondrial proteins promoting Ra …