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Page 1
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Horn-Ghetko D, et al. Among authors: prabu jr. Nature. 2021 Feb;590(7847):671-676. doi: 10.1038/s41586-021-03197-9. Epub 2021 Feb 3. Nature. 2021. PMID: 33536622 Free PMC article.
Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Chrustowicz J, Sherpa D, Li J, Langlois CR, Papadopoulou EC, Vu DT, Hehl LA, Karayel Ö, Beier V, von Gronau S, Müller J, Prabu JR, Mann M, Kleiger G, Alpi AF, Schulman BA. Chrustowicz J, et al. Among authors: prabu jr. Mol Cell. 2024 Jan 18;84(2):293-308.e14. doi: 10.1016/j.molcel.2023.11.027. Epub 2023 Dec 18. Mol Cell. 2024. PMID: 38113892 Free PMC article.
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Li J, et al. Among authors: prabu jr. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. Mol Cell. 2024. PMID: 38382526 Free PMC article.
Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA. Horn-Ghetko D, et al. Among authors: prabu jr. Nat Struct Mol Biol. 2024 Jul;31(7):1083-1094. doi: 10.1038/s41594-024-01257-y. Epub 2024 Apr 11. Nat Struct Mol Biol. 2024. PMID: 38605244 Free PMC article.
Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases.
Chrustowicz J, Sherpa D, Teyra J, Loke MS, Popowicz GM, Basquin J, Sattler M, Prabu JR, Sidhu SS, Schulman BA. Chrustowicz J, et al. Among authors: prabu jr. J Mol Biol. 2022 Jan 30;434(2):167347. doi: 10.1016/j.jmb.2021.167347. Epub 2021 Nov 9. J Mol Biol. 2022. PMID: 34767800 Free article.
26 results