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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1950 2
1951 2
1954 5
1955 3
1956 1
1957 2
1958 1
1959 1
1960 1
1961 1
1962 1
1964 3
1965 2
1966 2
1967 2
1968 1
1969 2
1970 3
1971 2
1972 3
1973 4
1974 8
1975 51
1976 64
1977 36
1978 66
1979 73
1980 72
1981 123
1982 156
1983 199
1984 263
1985 257
1986 224
1987 264
1988 254
1989 319
1990 345
1991 362
1992 402
1993 374
1994 377
1995 444
1996 407
1997 473
1998 557
1999 572
2000 626
2001 714
2002 844
2003 904
2004 1070
2005 1339
2006 1460
2007 1685
2008 1946
2009 2203
2010 2336
2011 2753
2012 2918
2013 3622
2014 3956
2015 4235
2016 4319
2017 4378
2018 4800
2019 5275
2020 6364
2021 7011
2022 7023
2023 6644
2024 5117
2025 6

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78,679 results

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Page 1
Gene Therapy Applications of Non-Human Lentiviral Vectors.
Munis AM. Munis AM. Viruses. 2020 Sep 29;12(10):1106. doi: 10.3390/v12101106. Viruses. 2020. PMID: 33003635 Free PMC article. Review.
LVs hold notable and inherent advantages over other gene transfer agents based on their ability to transduce non-dividing cells, permanently transform target cell genome, and allow stable, long-term transgene expression. LV systems based on non-human lentiviruses ar …
LVs hold notable and inherent advantages over other gene transfer agents based on their ability to transduce non-dividing cells, permanently …
Effects of Atrial Fibrillation on the Human Ventricle.
Pabel S, Knierim M, Stehle T, Alebrand F, Paulus M, Sieme M, Herwig M, Barsch F, Körtl T, Pöppl A, Wenner B, Ljubojevic-Holzer S, Molina CE, Dybkova N, Camboni D, Fischer TH, Sedej S, Scherr D, Schmid C, Brochhausen C, Hasenfuß G, Maier LS, Hamdani N, Streckfuss-Bömeke K, Sossalla S. Pabel S, et al. Circ Res. 2022 Apr;130(7):994-1010. doi: 10.1161/CIRCRESAHA.121.319718. Epub 2022 Feb 23. Circ Res. 2022. PMID: 35193397 Free PMC article.
Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction. OBJECTIVE: This study investigates the effects and molecular mechanisms of AF on the human LV. ...After 24 hours of AF-simulation, human …
Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction. OBJECTIVE: This study …
CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes.
Kapitza L, Ho N, Kerzel T, Frank AM, Thalheimer FB, Jamali A, Schaser T, Buchholz CJ, Hartmann J. Kapitza L, et al. Front Immunol. 2023 Aug 14;14:1183698. doi: 10.3389/fimmu.2023.1183698. eCollection 2023. Front Immunol. 2023. PMID: 37646032 Free PMC article.
Remarkably, higher amounts of less differentiated T cells are transduced and preserved upon long-term cultivation using 62L-LV compared to VSV-LV. Interestingly, shed CD62L neither altered the binding of 62L-LV particles to T cells nor impacted their transduc …
Remarkably, higher amounts of less differentiated T cells are transduced and preserved upon long-term cultivation using 62L-LV compar …
Ryanodine receptor inhibition with acute dantrolene treatment reduces arrhythmia susceptibility in human hearts.
George SA, Brennan-McLean JA, Trampel KA, Rytkin E, Faye NR, Knollmann BC, Efimov IR. George SA, et al. Am J Physiol Heart Circ Physiol. 2023 Oct 1;325(4):H720-H728. doi: 10.1152/ajpheart.00103.2023. Epub 2023 Aug 11. Am J Physiol Heart Circ Physiol. 2023. PMID: 37566110
Here, we tested the antiarrhythmic potential of dantrolene (RyR inhibitor) in human hearts. Human hearts not used in transplantation were obtained, and right ventricular outflow tract (RVOT) wedges and left ventricular (LV) slices were prepared. ...Isoprotere …
Here, we tested the antiarrhythmic potential of dantrolene (RyR inhibitor) in human hearts. Human hearts not used in transplan …
Alterations of housekeeping proteins in human aged and diseased hearts.
Yang M, Yan J, Wu A, Zhao W, Qin J, Pogwizd SM, Wu X, Yuan S, Ai X. Yang M, et al. Pflugers Arch. 2021 Mar;473(3):351-362. doi: 10.1007/s00424-021-02538-x. Epub 2021 Feb 26. Pflugers Arch. 2021. PMID: 33638007 Free PMC article.
Thus, all immunoblotting data were normalized with quantitative CB or PS data to calibrate potential loading variabilities. In the human heart, beta-actin was reduced in diabetic RA and LV, while GAPDH was altered in aged and diabetic RA but not LV. ...Intrig …
Thus, all immunoblotting data were normalized with quantitative CB or PS data to calibrate potential loading variabilities. In the human …
Gene Delivery to Human Limbal Stem Cells Using Viral Vectors.
Song L, Song Z, Fry NJ, Conatser L, Llanga T, Mei H, Kafri T, Hirsch ML. Song L, et al. Hum Gene Ther. 2019 Nov;30(11):1336-1348. doi: 10.1089/hum.2019.071. Epub 2019 Sep 25. Hum Gene Ther. 2019. PMID: 31392914 Free PMC article.
Following central intrastromal injection of human corneas, both LV and AAV6 transduced the stroma and endothelial cells, and AAV6 also transduced cells of the epithelia. ...The collective results demonstrate the effectiveness of LV for stable human LSC …
Following central intrastromal injection of human corneas, both LV and AAV6 transduced the stroma and endothelial cells, and A …
Human Obesity Attenuates Cardioprotection Conferred by Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells.
Yu S, Klomjit N, Jiang K, Zhu XY, Ferguson CM, Conley SM, Obeidat Y, Kellogg TA, McKenzie T, Heimbach JK, Lerman A, Lerman LO. Yu S, et al. J Cardiovasc Transl Res. 2023 Feb;16(1):221-232. doi: 10.1007/s12265-022-10279-0. Epub 2022 May 26. J Cardiovasc Transl Res. 2023. PMID: 35616881
Two weeks later, left ventricular (LV) function and deformation were estimated in vivo by micro-magnetic resonance imaging and myocardial damage ex vivo. Blood pressure and myocardial wall thickening were elevated in RVH + Vehicle and normalized only by lean-A-MSC. Both A- …
Two weeks later, left ventricular (LV) function and deformation were estimated in vivo by micro-magnetic resonance imaging and myocar …
Engineering Models of the Heart Left Ventricle.
Okhovatian S, Mohammadi MH, Rafatian N, Radisic M. Okhovatian S, et al. ACS Biomater Sci Eng. 2022 Jun 13;8(6):2144-2160. doi: 10.1021/acsbiomaterials.1c00636. Epub 2022 May 6. ACS Biomater Sci Eng. 2022. PMID: 35523206 Review.
Toward this goal, recent ground-breaking studies demonstrate the development of functional left ventricular (LV) models. LV models are artificially constructed 3D chambers that are capable of containing liquid within the engineered cavity and exhibit the functionali …
Toward this goal, recent ground-breaking studies demonstrate the development of functional left ventricular (LV) models. LV mo …
Spatiotemporal Progression of Early Human Ventricular Fibrillation.
Vidmar D, Krummen DE, Hayase J, Narayan SM, Ho G, Rappel WJ. Vidmar D, et al. JACC Clin Electrophysiol. 2017 Dec 11;3(12):1437-1446. doi: 10.1016/j.jacep.2017.04.009. Epub 2017 Aug 2. JACC Clin Electrophysiol. 2017. PMID: 29238755 Free PMC article.
OBJECTIVES: The objective of this study was to evaluate the spatio-temporal organization and progression of human ventricular fibrillation (VF) in the left (LV) and right (RV) ventricles. BACKGROUND: Studies suggest that localized sources contribute to VF maintenanc …
OBJECTIVES: The objective of this study was to evaluate the spatio-temporal organization and progression of human ventricular fibrill …
Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function.
O'Gallagher K, Cabaco AR, Ryan M, Roomi A, Gu H, Dancy L, Melikian N, Chowienczyk PJ, Webb AJ, Shah AM. O'Gallagher K, et al. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H175-H184. doi: 10.1152/ajpheart.00081.2021. Epub 2021 May 21. Am J Physiol Heart Circ Physiol. 2021. PMID: 34018850 Free PMC article.
LV pressure-volume relations were recorded. The primary end point was LV end-diastolic pressure (LVEDP). ...Intravenous nitrite infusion induced greater effects, with significant decreases in LVEDP, EDPVR, LVEST, LV dP/dt(min), tau, and mean arterial pressure …
LV pressure-volume relations were recorded. The primary end point was LV end-diastolic pressure (LVEDP). ...Intravenous nitrit …
78,679 results
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