A novel k-word relative measure for sequence comparison

Comput Biol Chem. 2014 Dec:53PB:331-338. doi: 10.1016/j.compbiolchem.2014.10.007. Epub 2014 Nov 7.

Abstract

In order to extract phylogenetic information from DNA sequences, the new normalized k-word average relative distance is proposed in this paper. The proposed measure was tested by discriminate analysis and phylogenetic analysis. The phylogenetic trees based on the Manhattan distance measure are reconstructed with k ranging from 1 to 12. At the same time, a new method is suggested to reduce the matrix dimension, can greatly lessen the amount of calculation and operation time. The experimental assessment demonstrated that our measure was efficient. What's more, comparing with other methods' results shows that our method is feasible and powerful for phylogenetic analysis.

Keywords: DNA sequences; Discriminate analysis; Phylogenetic analysis; Phylogenetic trees.