Structure-guided residence time optimization of a dabigatran reversal agent.
Schiele F, van Ryn J, Litzenburger T, Ritter M, Seeliger D, Nar H.
Schiele F, et al.
MAbs. 2015;7(5):871-80. doi: 10.1080/19420862.2015.1057364.
MAbs. 2015.
PMID: 26047352
Free PMC article.
Here, we report data on the antibody fragment aDabi-Fab2, a putative backup molecule for idarucizumab. Although aDabi-Fab2 completely reversed effects of dabigatran in a rat model in vivo, we observed significantly reduced duration of action compared to idarucizumab …
Here, we report data on the antibody fragment aDabi-Fab2, a putative backup molecule for idarucizumab. Although aDabi-Fab2 com …