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2021 2
2022 22
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In-vivo evaluation of molybdenum as bioabsorbable stent candidate.
Sikora-Jasinska M, Morath LM, Kwesiga MP, Plank ME, Nelson AL, Oliver AA, Bocks ML, Guillory RJ 2nd, Goldman J. Sikora-Jasinska M, et al. Bioact Mater. 2021 Nov 18;14:262-271. doi: 10.1016/j.bioactmat.2021.11.005. eCollection 2022 Aug. Bioact Mater. 2021. PMID: 35310360 Free PMC article.
The results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradable endovascular stent material. Moreover, Mo implants in mouse arteries avoided the typical cellular response that contributes to res …
The results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradab …
Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4.
Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Jussila AR, et al. J Invest Dermatol. 2022 Jun;142(6):1597-1606.e9. doi: 10.1016/j.jid.2021.10.025. Epub 2021 Nov 20. J Invest Dermatol. 2022. PMID: 34808238
Upon withdrawal from Wnt activation, Wnt-induced fibrotic remodeling was reversed in mouse skin-fully restoring skin architecture. Next, we demonstrated CD26/ DPP4 is a Wnt/beta-catenin-responsive gene and a functional mediator of fibrotic transformation. ...
Upon withdrawal from Wnt activation, Wnt-induced fibrotic remodeling was reversed in mouse skin-fully restoring skin architecture. Ne …
Tetrabenazine Mitigates Aberrant Release and Clearance of Dopamine in the Nigrostriatal System, and Alleviates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease.
Tseng KY, Kuo TT, Wang V, Huang EY, Ma KH, Olson L, Hoffer BJ, Chen YH. Tseng KY, et al. J Parkinsons Dis. 2022 May 16. doi: 10.3233/JPD-223195. Online ahead of print. J Parkinsons Dis. 2022. PMID: 35599497
BACKGROUND: L-DOPA-induced dyskinesia (LID), occurring with aberrant processing of exogenous L-DOPA in the dopamine-denervated striatum, is a main complication of levodopa treatment in Parkinson's disease. OBJECTIVE: To characterize the effects of the vesicular antagonist …
BACKGROUND: L-DOPA-induced dyskinesia (LID), occurring with aberrant processing of exogenous L-DOPA in the dopamine-denervated striatum, is …
Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice.
Frame G, Schuller A, Smith MA, Crish SD, Dengler-Crish CM. Frame G, et al. J Alzheimers Dis. 2022 May 18. doi: 10.3233/JAD-220016. Online ahead of print. J Alzheimers Dis. 2022. PMID: 35599482
BACKGROUND: Visual disturbances often precede cognitive dysfunction in patients with Alzheimer's disease (AD) and may coincide with early accumulation of amyloid-beta (Abeta) protein in the retina. ...RESULTS: 3xTg mice exhibited nuanced deficits in RGC electrical s …
BACKGROUND: Visual disturbances often precede cognitive dysfunction in patients with Alzheimer's disease (AD) and may coincide with e …
Loss of mouse Stmn2 function causes motor neuropathy.
Guerra San Juan I, Nash LA, Smith KS, Leyton-Jaimes MF, Qian M, Klim JR, Limone F, Dorr AB, Couto A, Pintacuda G, Joseph BJ, Whisenant DE, Noble C, Melnik V, Potter D, Holmes A, Burberry A, Verhage M, Eggan K. Guerra San Juan I, et al. Neuron. 2022 May 18;110(10):1671-1688.e6. doi: 10.1016/j.neuron.2022.02.011. Epub 2022 Mar 15. Neuron. 2022. PMID: 35294901
Thus far, it remains unresolved to what extent TDP43 loss of function directly contributes to motor system dysfunction. Here, we employed gene editing to find whether the mouse ortholog of the TDP43-regulated gene STMN2 has an important function in maintaining the motor sy …
Thus far, it remains unresolved to what extent TDP43 loss of function directly contributes to motor system dysfunction. Here, we employed ge …
Progressive skeletal defects caused by Kindlin3 deficiency, a model of autosomal recessive osteopetrosis in humans.
Dudiki T, Nascimento DW, Childs LS, Kareti S, Androjna C, Zhevlakova I, Byzova TV. Dudiki T, et al. Bone. 2022 Jul;160:116397. doi: 10.1016/j.bone.2022.116397. Epub 2022 Mar 25. Bone. 2022. PMID: 35342016 Free article.
Here, using inducible and constitutive tissue-specific Kindlin3 knockout (K3KO) mice, we show that the constitutive lack of embryonic-Kindlin3 in myeloid lineage cells causes growth retardation, edentulism, and skull deformity indicative of hydrocephaly. ...
Here, using inducible and constitutive tissue-specific Kindlin3 knockout (K3KO) mice, we show that the constitutive lack of embryonic …
Protective effects of phosphodiesterase 2 inhibitor against Aβ1-42 induced neuronal toxicity.
Yan Y, Gao S, Avasthi S, Zhao Y, Ye J, Tao Y, Wang W, Zhu X, Du F, O'Donnell JM, Xu Y. Yan Y, et al. Neuropharmacology. 2022 May 16;213:109128. doi: 10.1016/j.neuropharm.2022.109128. Online ahead of print. Neuropharmacology. 2022. PMID: 35588859
While whether memory enhancing effects of PDE2 inhibition on Alzheimer's disease mouse model are involved in antioxidant defense and neuronal remodeling, are largely unexplored. ...Moreover, microinjection of Abetao into the prefrontal cortex of mice increase …
While whether memory enhancing effects of PDE2 inhibition on Alzheimer's disease mouse model are involved in antioxidant defen …
Intestinal enteroendocrine cell signaling: Retinol-binding protein 2 (RBP2) and retinoid actions.
Calderon RM, Smith CA, Miedzybrodzka EL, Silvaroli JA, Golczak M, Gribble FM, Reimann F, Blaner WS. Calderon RM, et al. Endocrinology. 2022 May 12:bqac064. doi: 10.1210/endocr/bqac064. Online ahead of print. Endocrinology. 2022. PMID: 35552670
Retinol-binding protein 2-deficient (Rbp2-/-) mice are more prone to obesity, glucose intolerance, and hepatic steatosis than matched controls. Glucose-dependent insulinotropic polypeptide (GIP) blood levels are dysregulated in these mice. The present studies provid …
Retinol-binding protein 2-deficient (Rbp2-/-) mice are more prone to obesity, glucose intolerance, and hepatic steatosis than matched …
Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation.
Kuwabara JT, Hara A, Heckl JR, Peña B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Kuwabara JT, et al. J Mol Cell Cardiol. 2022 May 12:S0022-2828(22)00096-7. doi: 10.1016/j.yjmcc.2022.05.003. Online ahead of print. J Mol Cell Cardiol. 2022. PMID: 35569524
Therefore, we investigated the consequences of fibroblast loss at the time of cardiomyocyte maturation by depleting fibroblasts in the perinatal mouse. METHODS AND RESULTS: We evaluated the microenvironment of the perinatal heart in the absence of fibroblasts and the poten …
Therefore, we investigated the consequences of fibroblast loss at the time of cardiomyocyte maturation by depleting fibroblasts in the perin …
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