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Page 1
Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.
Wang YC, Koay YC, Pan C, Zhou Z, Tang W, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, Lusis AJ. Wang YC, et al. Circ Res. 2024 Feb 16;134(4):371-389. doi: 10.1161/CIRCRESAHA.123.322381. Epub 2024 Jan 24. Circ Res. 2024. PMID: 38264909 Free article.
It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult. METHODS: Metabolomic analyses in a mouse model of HFpEF showed that levels of indole-3-propionic acid (IPA), a metabolite produced by gut bacteria from t …
It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult. METHODS: Metabolomic …
TXNIP-mediated crosstalk between oxidative stress and glucose metabolism.
Kim S, Ge J, Kim D, Lee JJ, Choi YJ, Chen W, Bowman JW, Foo SS, Chang LC, Liang Q, Hara D, Choi I, Kim MH, Eoh H, Jung JU. Kim S, et al. PLoS One. 2024 Feb 8;19(2):e0292655. doi: 10.1371/journal.pone.0292655. eCollection 2024. PLoS One. 2024. PMID: 38329960 Free PMC article.
Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa.
Vasudevan S, Senapati S, Pendergast M, Park PS. Vasudevan S, et al. Nat Commun. 2024 Feb 16;15(1):1451. doi: 10.1038/s41467-024-45748-4. Nat Commun. 2024. PMID: 38365903 Free PMC article.
The effect of P23H and G188R misfolding mutations were examined in a heterologous expression system and knockin mouse models, including a mouse model generated here expressing the G188R rhodopsin mutant. ...
The effect of P23H and G188R misfolding mutations were examined in a heterologous expression system and knockin mouse models, includi …
Ultrasound-mediated drug-free theranostics for treatment of prostate cancer.
Perera RH, Berg FM, Abenojar EC, Nittayacharn P, Kim Y, Wang X, Basilion JP, Exner A. Perera RH, et al. Bioact Mater. 2024 Jan 20;35:45-55. doi: 10.1016/j.bioactmat.2023.12.012. eCollection 2024 May. Bioact Mater. 2024. PMID: 38304914 Free PMC article.
We observed that the internalized NBs and cellular compartments were disrupted after the PSMA-NB + TUS (targeted NB therapy or TNT) application, yet treated cells remained intact and viable. In vivo, PSMA-expressing tumors in mice receiving TNT treatment demonstrated a sig …
We observed that the internalized NBs and cellular compartments were disrupted after the PSMA-NB + TUS (targeted NB therapy or TNT) applicat …
Nitrogen assimilation by E. coli in the mammalian intestine.
Doranga S, Conway T. Doranga S, et al. mBio. 2024 Feb 21:e0002524. doi: 10.1128/mbio.00025-24. Online ahead of print. mBio. 2024. PMID: 38380942
Here, we sought to determine the specific nitrogen sources used by E. coli to colonize the streptomycin-treated mouse intestine. We began by investigating whether nitrogen is limiting in the intestine. ...Rescue experiments in mice showed that L-serine serves primar …
Here, we sought to determine the specific nitrogen sources used by E. coli to colonize the streptomycin-treated mouse intestine. We b …
Emerging roles for the ADAMTS-like family of matricellular proteins in cardiovascular disease through regulation of the extracellular microenvironment.
Rypdal KB, Apte SS, Lunde IG. Rypdal KB, et al. Mol Biol Rep. 2024 Feb 7;51(1):280. doi: 10.1007/s11033-024-09255-5. Mol Biol Rep. 2024. PMID: 38324186 Free PMC article. Review.
Expression of ADAMTSL genes is greatly increased in the myocardium during heart failure. Genetically modified mice recapitulate phenotypes of patients with ADAMTSL mutations and demonstrate important functions in the ECM. The novel functions thus disclosed are intriguing b …
Expression of ADAMTSL genes is greatly increased in the myocardium during heart failure. Genetically modified mice recapitulate pheno …
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Ramachandran K, Futtner CR, Sommars MA, Quattrocelli M, Omura Y, Fruzyna E, Wang JC, Waldeck NJ, Senagolage MD, Telles CG, Demonbreun AR, Prendergast E, Lai N, Arango D, Bederman IR, McNally EM, Barish GD. Ramachandran K, et al. Nat Metab. 2024 Feb 9. doi: 10.1038/s42255-024-00983-3. Online ahead of print. Nat Metab. 2024. PMID: 38337096
Here we discover an unexpected function for the transcriptional repressor B cell lymphoma 6 (BCL6) in muscle proteostasis and strength in mice. Skeletal muscle-specific Bcl6 ablation in utero or in adult mice results in over 30% decreased muscle mass and force produ …
Here we discover an unexpected function for the transcriptional repressor B cell lymphoma 6 (BCL6) in muscle proteostasis and strength in …
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment.
Flashner S, Shimonosono M, Tomita Y, Matsuura N, Ohashi S, Muto M, Klein-Szanto AJ, Alan Diehl J, Chen CH, Mochly-Rosen D, Weinberg KI, Nakagawa H. Flashner S, et al. Carcinogenesis. 2024 Feb 12;45(1-2):95-106. doi: 10.1093/carcin/bgad085. Carcinogenesis. 2024. PMID: 37978873
Caffeine Ameliorates Age-Related Hearing Loss by Downregulating the Inflammatory Pathway in Mice.
Zhang X, Cao R, Li C, Zhao H, Zhang R, Che J, Xie J, Tang N, Wang Y, Liu X, Zheng Q. Zhang X, et al. Otol Neurotol. 2024 Mar 1;45(3):227-237. doi: 10.1097/MAO.0000000000004098. Epub 2024 Feb 2. Otol Neurotol. 2024. PMID: 38320571
This study is to identify whether caffeine could ameliorate ARHL in mice and analyze its mechanism. METHODS: Caffeine was administered in drinking water to C57BL/6J mice from the age of 3 months to 12 months. ...Genes' expression were detected by Q-PCR, immunofluore …
This study is to identify whether caffeine could ameliorate ARHL in mice and analyze its mechanism. METHODS: Caffeine was administere …
Microglial Neuroinflammation-Independent Reversal of Demyelination of Corpus Callosum by Arsenic in a Cuprizone-Induced Demyelinating Mouse Model.
Kushwaha S, Saji J, Verma R, Singh V, Ansari JA, Mishra SK, Roy O, Patnaik S, Ghosh D. Kushwaha S, et al. Mol Neurobiol. 2024 Feb 14. doi: 10.1007/s12035-024-03978-z. Online ahead of print. Mol Neurobiol. 2024. PMID: 38353925
Cuprizone (CPZ), a copper chelator, generates oxidative stress and neuroinflammation, thereby inducing demyelination. Therefore, the CPZ-induced demyelinating mouse model (CPZ model) is widely used in research. The present study was intended to unravel a mechanism of inhib …
Cuprizone (CPZ), a copper chelator, generates oxidative stress and neuroinflammation, thereby inducing demyelination. Therefore, the CPZ-ind …
19 results