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36 results
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Page 1
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome.
Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Køber LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJ, Probstfield JL, Riddle MC, Solomon SD, Tardif JC; ELIXA Investigators. Pfeffer MA, et al. N Engl J Med. 2015 Dec 3;373(23):2247-57. doi: 10.1056/NEJMoa1509225. N Engl J Med. 2015. PMID: 26630143 Free article. Clinical Trial.
Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.
Wu W, Gardner A, Sachse FB, Sanguinetti MC. Wu W, et al. Mol Pharmacol. 2016 Oct;90(4):469-82. doi: 10.1124/mol.116.104091. Epub 2016 Aug 8. Mol Pharmacol. 2016. PMID: 27502018 Free PMC article.
Here we compare and contrast the mechanisms of actions of Rg3 on hERG1 with three other members of the ether-a-go-go (EAG) K(+) channel gene family, including EAG1 (Kv10.1), ERG3 (Kv11.3), and ELK1 (Kv12.1). All four channel types were heterologously expressed in Xenopus l …
Here we compare and contrast the mechanisms of actions of Rg3 on hERG1 with three other members of the ether-a-go-go (EAG) K(+) chann …
Selectivity filter modalities and rapid inactivation of the hERG1 channel.
Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. Miranda WE, et al. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2795-2804. doi: 10.1073/pnas.1909196117. Epub 2020 Jan 24. Proc Natl Acad Sci U S A. 2020. PMID: 31980532 Free PMC article.
The human ether-a-go-go-related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization. ...Overall, our findings provide an understanding of the molecular mechanisms controlling selective transport in K( …
The human ether-a-go-go-related gene (hERG1) channel conducts small outward K(+) currents that are critical for cardiomyocyte membran …
Mixed Markov models.
Fridman A. Fridman A. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8092-6. doi: 10.1073/pnas.0731829100. Epub 2003 Jun 26. Proc Natl Acad Sci U S A. 2003. PMID: 12829802 Free PMC article.
In this article, we study the analytical and computational properties of mixed Markov models. In particular, we show that positive mixed models have a local Markov property that is equivalent to their global factorization. We also describe a computationally efficien …
In this article, we study the analytical and computational properties of mixed Markov models. In particular, we show that positive mi …
Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Labro AJ, et al. Nat Commun. 2015 Dec 17;6:10173. doi: 10.1038/ncomms10173. Nat Commun. 2015. PMID: 26673941 Free PMC article.
Here, we demonstrate that Kv3.1b channels solve this problem by producing resurgent K(+) currents during repolarization, thus ensuring enough repolarizing power to terminate each AP. Unlike previously described resurgent Na(+) and K(+) currents, Kv3.1b's resurgent c …
Here, we demonstrate that Kv3.1b channels solve this problem by producing resurgent K(+) currents during repolarization, thus ensurin …
Prediction of plant mRNA polyadenylation sites.
Wu X, Ji G, Li QQ. Wu X, et al. Methods Mol Biol. 2015;1255:13-23. doi: 10.1007/978-1-4939-2175-1_2. Methods Mol Biol. 2015. PMID: 25487200
PASS [Poly(A) Site Sleuth] and PAC [Poly(A) site Classifier] were developed to predict poly(A) sites in plants. PASS was built based on the Generalized Hidden Markov Model (GHMM), which consists of four functional modules: input model, poly(A) site recognition module, grap …
PASS [Poly(A) Site Sleuth] and PAC [Poly(A) site Classifier] were developed to predict poly(A) sites in plants. PASS was built based on the …
Ion-triggered selectivity in bacterial sodium channels.
Furini S, Domene C. Furini S, et al. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5450-5455. doi: 10.1073/pnas.1722516115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735669 Free PMC article.
Although this liquid-like environment looks optimal for rapid conduction of Na(+), it seems incompatible with efficient discrimination between similar ion species, such as Na(+) and K(+), through steric effects. Here extensive molecular dynamics simulations, combined with …
Although this liquid-like environment looks optimal for rapid conduction of Na(+), it seems incompatible with efficient discrimination betwe …
Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.
Garg V, Sachse FB, Sanguinetti MC. Garg V, et al. J Gen Physiol. 2012 Sep;140(3):307-24. doi: 10.1085/jgp.201210826. J Gen Physiol. 2012. PMID: 22930803 Free PMC article.
Ether-a-go-go (EAG) and EAG-related gene (ERG) K(+) channels are close homologues but differ markedly in their gating properties. ...The mutation Y464A in the S6 segment also induced inactivation of EAG1, with a time course and voltage dependence similar to that caused by …
Ether-a-go-go (EAG) and EAG-related gene (ERG) K(+) channels are close homologues but differ markedly in their gating properties. ... …
Random K-noncrossing RNA structures.
Chen WY, Han HS, Reidys CM. Chen WY, et al. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22061-6. doi: 10.1073/pnas.0907269106. Epub 2009 Dec 11. Proc Natl Acad Sci U S A. 2009. PMID: 20018731 Free PMC article.
In this paper, we introduce a combinatorial framework that provides an interpretation of RNA pseudoknot structures as sampling paths of a Markov process. Our results facilitate a variety of applications ranging from the energy-based sampling of pseudoknot structures as wel …
In this paper, we introduce a combinatorial framework that provides an interpretation of RNA pseudoknot structures as sampling paths of a …
Neyman, Markov processes and survival analysis.
Yang G. Yang G. Lifetime Data Anal. 2013 Jul;19(3):393-411. doi: 10.1007/s10985-013-9250-z. Epub 2013 Mar 2. Lifetime Data Anal. 2013. PMID: 23456282
We revisit the F-N model, and compare it with the Kaplan-Meier (K-M) formulation for right censored data. The comparison offers a way to generalize the K-M formulation to include risks of recovery and relapses in the calculation of a patient's survival probability. …
We revisit the F-N model, and compare it with the Kaplan-Meier (K-M) formulation for right censored data. The comparison offers a way …
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