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Year Number of Results
1949 4
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1951 4
1952 2
1953 1
1954 3
1956 3
1957 1
1958 2
1959 3
1960 3
1961 4
1962 1
1963 2
1965 1
1966 1
1967 1
1969 1
1970 2
1971 1
1973 1
1974 5
1975 1
1976 3
1977 2
1978 1
1979 3
1980 5
1981 5
1982 9
1983 7
1984 9
1985 7
1986 8
1987 3
1988 11
1989 5
1990 17
1991 14
1992 4
1993 4
1994 6
1995 8
1996 8
1997 3
1998 3
1999 6
2000 6
2001 11
2002 9
2003 5
2004 14
2005 16
2006 16
2007 24
2008 23
2009 28
2010 33
2011 33
2012 46
2013 38
2014 62
2015 79
2016 99
2017 75
2018 98
2019 103
2020 107
2021 148
2022 128
2023 97
2024 97

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1,440 results

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Targeting Bacterial Biofilm: A New LecA Multivalent Ligand with Inhibitory Activity.
Palmioli A, Sperandeo P, Polissi A, Airoldi C. Palmioli A, et al. Chembiochem. 2019 Dec 2;20(23):2911-2915. doi: 10.1002/cbic.201900383. Epub 2019 Sep 24. Chembiochem. 2019. PMID: 31216375 Free article.
Infections caused by Pseudomonas aeruginosa are of great concern, especially for immunocompromised and cystic fibrosis patients. P. aeruginosa lectins LecA and LecB are virulence factors and play a key role in establishing biofilm; therefore, inhibition of the function of …
Infections caused by Pseudomonas aeruginosa are of great concern, especially for immunocompromised and cystic fibrosis patients. P. aerugino …
LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa.
Kuhaudomlarp S, Gillon E, Varrot A, Imberty A. Kuhaudomlarp S, et al. Methods Mol Biol. 2020;2132:257-266. doi: 10.1007/978-1-0716-0430-4_25. Methods Mol Biol. 2020. PMID: 32306333
LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. ...
LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. ...
LUCA to LECA, the Lucacene: A model for the gigayear delay from the first prokaryote to eukaryogenesis.
Mikhailovsky GE, Gordon R. Mikhailovsky GE, et al. Biosystems. 2021 Jul;205:104415. doi: 10.1016/j.biosystems.2021.104415. Epub 2021 Apr 1. Biosystems. 2021. PMID: 33812918
This period, from LUCA (Last Universal Common Ancestor) to LECA (Last Eucaryotic Common Ancestor), we have named the Lucacene, to suggest all prokaryotic descendants of LUCA before the appearance of LECA. ...
This period, from LUCA (Last Universal Common Ancestor) to LECA (Last Eucaryotic Common Ancestor), we have named the Lucacene, to sug …
A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa.
Novoa A, Eierhoff T, Topin J, Varrot A, Barluenga S, Imberty A, Römer W, Winssinger N. Novoa A, et al. Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8885-9. doi: 10.1002/anie.201402831. Epub 2014 Jul 7. Angew Chem Int Ed Engl. 2014. PMID: 25044671
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. ...Crystal structures of LecA complexed with the ligand together with modeling studies confirmed its ability to chelate two binding sites of Lec …
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. ...Crystal str …
Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin.
Fu O, Pukin AV, Quarles van Ufford HC, Kemmink J, de Mol NJ, Pieters RJ. Fu O, et al. ChemistryOpen. 2015 Aug;4(4):463-70. doi: 10.1002/open.201402171. Epub 2015 Mar 9. ChemistryOpen. 2015. PMID: 26478841 Free PMC article.
The bacterial adhesion lectin LecA is an attractive target for interference with the infectivity of its producer P. aeruginosa. ...The introduction of positively charged, negatively charged, and also lipophilic functional groups was successful. The compounds were good L …
The bacterial adhesion lectin LecA is an attractive target for interference with the infectivity of its producer P. aeruginosa. ...Th …
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate.
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch AKH, Imberty A, Titz A. Zahorska E, et al. Chem Commun (Camb). 2020 Aug 4;56(62):8822-8825. doi: 10.1039/d0cc03490h. Chem Commun (Camb). 2020. PMID: 32628229
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent presentation of bi …
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin …
Expression, purification, and evaluation of recombinant LecA as a candidate for an amebic colitis vaccine.
Barroso L, Abhyankar M, Noor Z, Read K, Pedersen K, White R, Fox C, Petri WA Jr, Lyerly D. Barroso L, et al. Vaccine. 2014 Feb 26;32(10):1218-24. doi: 10.1016/j.vaccine.2013.06.056. Epub 2013 Jul 1. Vaccine. 2014. PMID: 23827311 Free PMC article.
Our efforts to develop a vaccine against this pathogen have focused on an internal 578 amino acid fragment, designated LecA, located within the cysteine-rich region of the heavy chain subunit because: (i) it is a major target of adherence-blocking antibodies of seropositiv …
Our efforts to develop a vaccine against this pathogen have focused on an internal 578 amino acid fragment, designated LecA, located …
The virome of the last eukaryotic common ancestor and eukaryogenesis.
Krupovic M, Dolja VV, Koonin EV. Krupovic M, et al. Nat Microbiol. 2023 Jun;8(6):1008-1017. doi: 10.1038/s41564-023-01378-y. Epub 2023 May 1. Nat Microbiol. 2023. PMID: 37127702 Free PMC article. Review.
All extant eukaryotes descend from the last eukaryotic common ancestor (LECA), which is thought to have featured complex cellular organization. To gain insight into LECA biology and eukaryogenesis-the origin of the eukaryotic cell, which remains poorly understood-we …
All extant eukaryotes descend from the last eukaryotic common ancestor (LECA), which is thought to have featured complex cellular org …
Multivalent thioglycopeptoids via photoclick chemistry: potent affinities towards LecA and BC2L-A lectins.
Caumes C, Gillon E, Legeret B, Taillefumier C, Imberty A, Faure S. Caumes C, et al. Chem Commun (Camb). 2015 Aug 7;51(61):12301-4. doi: 10.1039/c5cc04646g. Chem Commun (Camb). 2015. PMID: 26137967
A tetrameric cyclic beta-peptoid scaffold displaying 1-thio-beta-d-galactose or 1-thio-alpha-d-mannose has revealed by ITC experiments efficient binding potency for bacterial lectins LecA and BC2L-A, respectively....
A tetrameric cyclic beta-peptoid scaffold displaying 1-thio-beta-d-galactose or 1-thio-alpha-d-mannose has revealed by ITC experiments effic …
1,440 results