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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 4
1950 4
1951 4
1952 2
1953 1
1954 3
1956 3
1957 1
1958 2
1959 3
1960 3
1961 4
1962 1
1963 2
1965 1
1966 1
1967 1
1969 1
1970 2
1971 1
1973 1
1974 5
1975 1
1976 3
1977 2
1978 1
1979 3
1980 5
1981 5
1982 9
1983 7
1984 9
1985 7
1986 8
1987 3
1988 11
1989 5
1990 17
1991 14
1992 4
1993 4
1994 6
1995 8
1996 8
1997 3
1998 3
1999 6
2000 6
2001 11
2002 9
2003 5
2004 14
2005 16
2006 16
2007 24
2008 22
2009 28
2010 32
2011 33
2012 46
2013 38
2014 61
2015 78
2016 99
2017 74
2018 98
2019 102
2020 68
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991 results
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Page 1
Targeting Bacterial Biofilm: A New LecA Multivalent Ligand with Inhibitory Activity.
Palmioli A, Sperandeo P, Polissi A, Airoldi C. Palmioli A, et al. Chembiochem. 2019 Dec 2;20(23):2911-2915. doi: 10.1002/cbic.201900383. Epub 2019 Sep 24. Chembiochem. 2019. PMID: 31216375
P. aeruginosa lectins LecA and LecB are virulence factors and play a key role in establishing biofilm; therefore, inhibition of the function of these proteins has potential in dismantling the bacterium from the protective biofilm environment and in restoring the activity o …
P. aeruginosa lectins LecA and LecB are virulence factors and play a key role in establishing biofilm; therefore, inhibition of the f …
Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa.
Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, Hartmann L, Titz A. Joachim I, et al. Org Biomol Chem. 2016 Aug 16;14(33):7933-48. doi: 10.1039/c6ob01313a. Org Biomol Chem. 2016. PMID: 27488655
The bacterial protein LecA, a C-type lectin, is a virulence factor and an integral component for biofilm formation. Inhibition of LecA with its carbohydrate ligands results in reduced biofilm mass, a potential Achilles heel for treatment. ...In addition, we evaluate …
The bacterial protein LecA, a C-type lectin, is a virulence factor and an integral component for biofilm formation. Inhibition of …
A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa.
Novoa A, Eierhoff T, Topin J, Varrot A, Barluenga S, Imberty A, Römer W, Winssinger N. Novoa A, et al. Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8885-9. doi: 10.1002/anie.201402831. Epub 2014 Jul 7. Angew Chem Int Ed Engl. 2014. PMID: 25044671
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. Ligands competing with human glycoconjugates for LecA binding are thus promising candidates to counteract P. aeruginosa infections. ...Crystal stru …
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. Ligands compet …
Concepts of the last eukaryotic common ancestor.
O'Malley MA, Leger MM, Wideman JG, Ruiz-Trillo I. O'Malley MA, et al. Nat Ecol Evol. 2019 Mar;3(3):338-344. doi: 10.1038/s41559-019-0796-3. Epub 2019 Feb 18. Nat Ecol Evol. 2019. PMID: 30778187 Review.
Does it affect evolutionary interpretations of LECA's cellular functions? Finally, we examine whether this novel pangenomic concept of LECA has implications for phylogenetic reconstructions of early eukaryote evolution. Our aim is to add to the conceptual toolkit fo …
Does it affect evolutionary interpretations of LECA's cellular functions? Finally, we examine whether this novel pangenomic concept o …
Development of Pseudomonas aeruginosa Lectin LecA Inhibitor by using Bivalent Galactosides Supported on Polyproline Peptide Scaffolds.
Huang SF, Lin CH, Lai YT, Tsai CL, Cheng TR, Wang SK. Huang SF, et al. Chem Asian J. 2018 Mar 16;13(6):686-700. doi: 10.1002/asia.201701724. Epub 2018 Feb 28. Chem Asian J. 2018. PMID: 29380519
LecA is a galactose-binding tetrameric lectin from Pseudomonas aeruginosa involved in infection and biofilm formation. The emergent antibiotic resistance of P. aeruginosa has made LecA a promising pharmaceutical target to treat such infections. To develop LecA
LecA is a galactose-binding tetrameric lectin from Pseudomonas aeruginosa involved in infection and biofilm formation. The emergent a
Expression, purification, and evaluation of recombinant LecA as a candidate for an amebic colitis vaccine.
Barroso L, Abhyankar M, Noor Z, Read K, Pedersen K, White R, Fox C, Petri WA Jr, Lyerly D. Barroso L, et al. Vaccine. 2014 Feb 26;32(10):1218-24. doi: 10.1016/j.vaccine.2013.06.056. Epub 2013 Jul 1. Vaccine. 2014. PMID: 23827311 Free PMC article.
We developed a purification process for preparing highly purified non-tagged LecA using a codon-optimized gene expressed in Escherichia coli. ...Immunization of CBA mice with LecA resulted in significant protection against cecal colitis. Our procedure yields suffici …
We developed a purification process for preparing highly purified non-tagged LecA using a codon-optimized gene expressed in Escherich …
Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes.
Worstell NC, Singla A, Saenkham P, Galbadage T, Sule P, Lee D, Mohr A, Kwon JS, Cirillo JD, Wu HJ. Worstell NC, et al. Sci Rep. 2018 May 30;8(1):8419. doi: 10.1038/s41598-018-26643-7. Sci Rep. 2018. PMID: 29849092 Free PMC article.
To understand the influence of RD, we also modeled LecA's two-step binding process with membranes using a kinetic Monte Carlo simulation. The simulation identified the frequency of low-affinity ligand encounters with bound LecA and the bound LecA's retention …
To understand the influence of RD, we also modeled LecA's two-step binding process with membranes using a kinetic Monte Carlo simulat …
Mosaic origin of the eukaryotic kinetochore.
Tromer EC, van Hooff JJE, Kops GJPL, Snel B. Tromer EC, et al. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12873-12882. doi: 10.1073/pnas.1821945116. Epub 2019 May 24. Proc Natl Acad Sci U S A. 2019. PMID: 31127038 Free PMC article.
We find that gene duplications played a major role in shaping the kinetochore; more than half of LECA's kinetochore proteins have other kinetochore proteins as closest homologs. Some of these have no detectable homology to any other eukaryotic protein, suggesting that they …
We find that gene duplications played a major role in shaping the kinetochore; more than half of LECA's kinetochore proteins have oth …
Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels.
Kim HS, Cha E, Kim Y, Jeon YH, Olson BH, Byun Y, Park HD. Kim HS, et al. Sci Rep. 2016 May 4;6:25318. doi: 10.1038/srep25318. Sci Rep. 2016. PMID: 27141909 Free PMC article.
Binding of raffinose to a carbohydrate-binding protein called LecA was the cause of biofilm inhibition and altered phenotypes. ...
Binding of raffinose to a carbohydrate-binding protein called LecA was the cause of biofilm inhibition and altered phenotypes. ...
Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands.
Wang S, Dupin L, Noël M, Carroux CJ, Renaud L, Géhin T, Meyer A, Souteyrand E, Vasseur JJ, Vergoten G, Chevolot Y, Morvan F, Vidal S. Wang S, et al. Chemistry. 2016 Aug 8;22(33):11785-94. doi: 10.1002/chem.201602047. Epub 2016 Jul 14. Chemistry. 2016. PMID: 27412649
LecA and LecB are lectins of Pseudomonas aeruginosa implicated in biofilm formation. A series of 27 LecA-targeting glycoclusters have been synthesized. ...
LecA and LecB are lectins of Pseudomonas aeruginosa implicated in biofilm formation. A series of 27 LecA-targeting glycocluste
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