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A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
Miller BR, Gonzaga-Jauregui C, Brigatti KW, de Jong J, Breese RS, Ko SY, Puffenberger EG, Van Hout C, Young M, Luna VM, Staples J, First MB, Gregoire HJ, Dwork AJ, Pefanis E, McCarthy S, Brydges S, Rojas J, Ye B, Stahl E, Di Gioia SA, Hen R, Elwood K, Rosoklija G, Li D, Mellis S, Carey D, Croll SD, Overton JD, Macdonald LE, Economides AN, Shuldiner AR, Chuhma N, Rayport S, Amin N, Kushner SA, Alessandri-Haber N, Markx S, Strauss KA. Miller BR, et al. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2404754122. doi: 10.1073/pnas.2404754122. Epub 2025 Apr 14. Proc Natl Acad Sci U S A. 2025. PMID: 40228124 Free PMC article.
In an extended Old Order Mennonite family cohort, we identified a rare missense variant in GPR156 (c.1599G>T, p.Glu533Asp) associated with a two-fold increase in the relative risk of MDD. ...Insertion of a human sequence containing c.1599G>T into the murine Gp …
In an extended Old Order Mennonite family cohort, we identified a rare missense variant in GPR156 (c.1599G>T, p.Glu533Asp) associa …
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial.
M KK, V H N, P Y, N N, M P W, M R, F B, G L, J D, N H, J H, H L, M MK, M S, M T, A C, C B K, C D B S, D A, S S, J T, T O, H S, S B, J D, A L, J J, J U, A L, J K, J G, E L, L R, P S, P S, T G, A M, C L, J N, P D, K A, P J M, J W, M G, M O, P H, A P, R H, D P, P J, A N, M H, M P H, M I, C S, M N, M J, C R, J B, D R, Y A, A AF, C YW, A A, A S, C A, M R, R P, A D, M R, B V, F T, P T P, H F, T C, J C J, M B S. M KK, et al. Acta Anaesthesiol Scand. 2026 Jul;70(6):e70276. doi: 10.1111/aas.70276. Acta Anaesthesiol Scand. 2026. PMID: 42298739 Free PMC article.