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Invasive Treatment Strategy for Older Patients with Myocardial Infarction.
Kunadian V, Mossop H, Shields C, Bardgett M, Watts P, Teare MD, Pritchard J, Adams-Hall J, Runnett C, Ripley DP, Carter J, Quigley J, Cooke J, Austin D, Murphy J, Kelly D, McGowan J, Veerasamy M, Felmeden D, Contractor H, Mutgi S, Irving J, Lindsay S, Galasko G, Lee K, Sultan A, Dastidar AG, Hussain S, Haq IU, de Belder M, Denvir M, Flather M, Storey RF, Newby DE, Pocock SJ, Fox KAA; British Heart Foundation SENIOR-RITA Trial Team and Investigators. Kunadian V, et al. N Engl J Med. 2024 Nov 7;391(18):1673-1684. doi: 10.1056/NEJMoa2407791. Epub 2024 Sep 1. N Engl J Med. 2024. PMID: 39225274 Free article. Clinical Trial.
Patients who were frail or had a high burden of coexisting conditions were eligible. The primary outcome was a composite of death from cardiovascular causes (cardiovascular death) or nonfatal myocardial infarction assessed in a time-to-event analysis. ...CONC …
Patients who were frail or had a high burden of coexisting conditions were eligible. The primary outcome was a composite of de …
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation.
Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, Hardie M, Heels-Ansdell D, Alhazzani W, Marshall J, Muscedere J, Myburgh J, English S, Arabi YM, Ostermann M, Knowles S, Hammond N, Byrne KM, Chapman M, Venkatesh B, Young P, Rajbhandari D, Poole A, Al-Fares A, Reis G, Johnson D, Iqbal M, Hall R, Meade M, Hand L, Duan E, Clarke F, Dionne JC, Tsang JLY, Rochwerg B, Karachi T, Lamontagne F, D'Aragon F, St Arnaud C, Reeve B, Geagea A, Niven D, Vazquez-Grande G, Zarychanski R, Ovakim D, Wood G, Burns KEA, Goffi A, Wilcox ME, Henderson W, Forrest D, Fowler R, Adhikari NKJ, Ball I, Mele T, Binnie A, Trop S, Mehta S, Morgan I, Loubani O, Vanstone M, Fiest K, Charbonney E, Cavayas YA, Archambault P, Rewa OG, Lau V, Kristof AS, Khwaja K, Williamson D, Kanji S, Sy E, Dennis B, Reynolds S, Marquis F, Lellouche F, Rahman A, Hosek P, Barletta JF, Cirrone R, Tutschka M, Xie F, Billot L, Thabane L, Finfer S; REVISE Investigators. Cook D, et al. N Engl J Med. 2024 Jul 4;391(1):9-20. doi: 10.1056/NEJMoa2404245. Epub 2024 Jun 14. N Engl J Med. 2024. PMID: 38875111 Clinical Trial.
METHODS: In this international, randomized trial, we assigned critically ill adults who were undergoing invasive ventilation to receive intravenous pantoprazole (at a dose of 40 mg daily) or matching placebo. The primary efficacy outcome was clinically important upper gast …
METHODS: In this international, randomized trial, we assigned critically ill adults who were undergoing invasive ventilation to receive intr …
Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer.
von Minckwitz G, Procter M, de Azambuja E, Zardavas D, Benyunes M, Viale G, Suter T, Arahmani A, Rouchet N, Clark E, Knott A, Lang I, Levy C, Yardley DA, Bines J, Gelber RD, Piccart M, Baselga J; APHINITY Steering Committee and Investigators. von Minckwitz G, et al. N Engl J Med. 2017 Jul 13;377(2):122-131. doi: 10.1056/NEJMoa1703643. Epub 2017 Jun 5. N Engl J Med. 2017. PMID: 28581356 Free PMC article. Clinical Trial.
METHODS: We randomly assigned patients with node-positive or high-risk node-negative HER2-positive, operable breast cancer to receive either pertuzumab or placebo added to standard adjuvant chemotherapy plus 1 year of treatment with trastuzumab. We assumed a 3-year invasiv …
METHODS: We randomly assigned patients with node-positive or high-risk node-negative HER2-positive, operable breast cancer to receive either …
Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies.
Li H, Zandberg DP, Kulkarni A, Chiosea SI, Santos PM, Isett BR, Joy M, Sica GL, Contrera KJ, Tatsuoka CM, Brand M, Duvvuri U, Kim S, Kubik M, Sridharan S, Tu F, Chen J, Bruno TC, Vignali DAA, Cillo AR, Bao R, Wang JH, Vujanovic L, Ferris RL. Li H, et al. Cancer Cell. 2025 Apr 14;43(4):757-775.e8. doi: 10.1016/j.ccell.2025.02.026. Epub 2025 Mar 13. Cancer Cell. 2025. PMID: 40086437 Free PMC article. Clinical Trial.
We leverage a clinical trial (NCT04080804) that compared neoadjuvant anti-PD-1, anti-PD-1+CTLA-4, and anti-PD-1+LAG-3 therapies in head and neck squamous cell carcinoma patients. ...To address whether successful immune checkpoint inhibitor (ICI) regimens act through simila …
We leverage a clinical trial (NCT04080804) that compared neoadjuvant anti-PD-1, anti-PD-1+CTLA-4, and anti-PD-1+LAG-3 therapies in he …
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Causes of Death Collaborators. GBD 2023 Causes of Death Collaborators. Lancet. 2025 Oct 18;406(10513):1811-1872. doi: 10.1016/S0140-6736(25)01917-8. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092928 Free PMC article.
We used a modelling tool developed for GBD, the Cause of Death Ensemble model (CODEm), to estimate cause-specific death rates for most causes. ...Probability of death was calculated as the chance of dying from a given cause in a specific age period, for a …
We used a modelling tool developed for GBD, the Cause of Death Ensemble model (CODEm), to estimate cause-specific death rates for mos …
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. ...Remarkable health gains were made for communicable, ma …
BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framewo …
Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment.
Onkar S, Cui J, Zou J, Cardello C, Cillo AR, Uddin MR, Sagan A, Joy M, Osmanbeyoglu HU, Pogue-Geile KL, McAuliffe PF, Lucas PC, Tseng GC, Lee AV, Bruno TC, Oesterreich S, Vignali DAA. Onkar S, et al. Nat Cancer. 2023 Apr;4(4):516-534. doi: 10.1038/s43018-023-00527-w. Epub 2023 Mar 16. Nat Cancer. 2023. PMID: 36927792 Free PMC article.
To investigate this, we performed phenotypic, transcriptional and functional analyses for a cohort of treatment-naive IDC (n = 94) and ILC (n = 87) tumors. We show that macrophages, and not T cells, are the predominant immune cells infiltrating the tumor bed and the most t …
To investigate this, we performed phenotypic, transcriptional and functional analyses for a cohort of treatment-naive IDC (n = 94) an …
Play-mirth theory: a cognitive appraisal theory of humor.
Hatzithomas L. Hatzithomas L. Front Psychol. 2024 Dec 6;15:1473742. doi: 10.3389/fpsyg.2024.1473742. eCollection 2024. Front Psychol. 2024. PMID: 39712539 Free PMC article.
This work aims to introduce a general theory of humor elicitation and appreciation, the play-mirth theory, which is based on the cognitive appraisal perspective. Two experiments test the theory's central hypothesis: that is, to experience humor, one must interpret (a …
This work aims to introduce a general theory of humor elicitation and appreciation, the play-mirth theory, which is based on the cogn …
Novel Therapies for the Treatment of HER2-Positive Advanced Breast Cancer: A Canadian Perspective.
Ferrario C, Christofides A, Joy AA, Laing K, Gelmon K, Brezden-Masley C. Ferrario C, et al. Curr Oncol. 2022 Apr 13;29(4):2720-2734. doi: 10.3390/curroncol29040222. Curr Oncol. 2022. PMID: 35448196 Free PMC article. Review.
In the first-line setting, we can potentially cure a selected number of patients treated with pertuzumab + trastuzumab + taxane. In the second-line setting, clinical trials show that trastuzumab deruxtecan (T-DXd) is a highly effective option, resulting in a …
In the first-line setting, we can potentially cure a selected number of patients treated with pertuzumab + trastuzumab + taxane. In t …
Joyful and serious intentions in the work of hospital clowns: a meta-analysis based on a 7-year research project conducted in three parts.
Linge L. Linge L. Int J Qual Stud Health Well-being. 2013 Jan 4;8:1-8. doi: 10.3402/qhw.v8i0.18907. Int J Qual Stud Health Well-being. 2013. PMID: 23336988 Free PMC article.
The meta-analysis revealed the unique aspects of hospital clowns' work with respect to: a) a quality of care that transcends boundaries, that is, a magical safe area where demands and adjustment were temporarily set aside and where the lighter side of life to …
The meta-analysis revealed the unique aspects of hospital clowns' work with respect to: a) a quality of care that transcends b …
37 results