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Year Number of Results
1805 1
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1818 1
1822 2
1823 1
1830 2
1832 1
1856 1
1858 4
1859 1
1860 2
1869 1
1878 1
1879 1
1880 3
1881 1
1886 1
1887 2
1890 1
1893 1
1894 1
1895 1
1896 2
1902 2
1903 1
1906 1
1909 3
1912 1
1916 1
1918 1
1920 1
1921 2
1922 1
1923 2
1925 2
1926 1
1929 2
1930 2
1931 2
1932 2
1934 1
1935 3
1939 2
1940 2
1945 3
1946 2
1947 5
1948 5
1949 6
1950 13
1951 18
1952 15
1953 23
1954 23
1955 42
1956 30
1957 34
1958 41
1959 39
1960 34
1961 35
1962 31
1963 25
1964 61
1965 65
1966 61
1967 62
1968 67
1969 75
1970 78
1971 61
1972 72
1973 95
1974 75
1975 103
1976 92
1977 101
1978 117
1979 101
1980 112
1981 120
1982 118
1983 120
1984 134
1985 121
1986 135
1987 133
1988 139
1989 178
1990 171
1991 170
1992 181
1993 1066
1994 200
1995 239
1996 244
1997 278
1998 321
1999 380
2000 464
2001 566
2002 686
2003 692
2004 773
2005 932
2006 1030
2007 1111
2008 1255
2009 1328
2010 1420
2011 1512
2012 1600
2013 1832
2014 2108
2015 2301
2016 2041
2017 2081
2018 2206
2019 2339
2020 2781
2021 3025
2022 3046
2023 3024
2024 988

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41,381 results

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Page 1
The ADAM metalloproteinases.
Edwards DR, Handsley MM, Pennington CJ. Edwards DR, et al. Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008 Aug 15. Mol Aspects Med. 2008. PMID: 18762209 Free PMC article. Review.
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its function is essential for the development of epithelial tissues. Several other ADAMs have important sheddase functions in particular tissue con …
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its fun …
Necroptosis, ADAM proteases and intestinal (dys)function.
Heib M, Rose-John S, Adam D. Heib M, et al. Int Rev Cell Mol Biol. 2020;353:83-152. doi: 10.1016/bs.ircmb.2020.02.001. Epub 2020 Mar 5. Int Rev Cell Mol Biol. 2020. PMID: 32381179 Review.
Equally important for organismal homeostasis, ADAM proteases control cellular processes such as development and differentiation, immune responses or tissue regeneration. Notably, necroptosis as well as ADAM proteases have been implicated in the control of inflammato …
Equally important for organismal homeostasis, ADAM proteases control cellular processes such as development and differentiation, immu …
Inhibition of MMPs and ADAM/ADAMTS.
Malemud CJ. Malemud CJ. Biochem Pharmacol. 2019 Jul;165:33-40. doi: 10.1016/j.bcp.2019.02.033. Epub 2019 Feb 28. Biochem Pharmacol. 2019. PMID: 30826330 Free PMC article. Review.
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial joints characteristic of rheumatoid arthritis and osteoarthritis. MMP, ADAM and ADAMTS production is greatly increased under the influ …
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial j …
ADAM Metalloproteinases as Potential Drug Targets.
Camodeca C, Cuffaro D, Nuti E, Rossello A. Camodeca C, et al. Curr Med Chem. 2019;26(15):2661-2689. doi: 10.2174/0929867325666180326164104. Curr Med Chem. 2019. PMID: 29589526 Review.
ADAM-17: the enzyme that does it all.
Gooz M. Gooz M. Crit Rev Biochem Mol Biol. 2010 Apr;45(2):146-69. doi: 10.3109/10409231003628015. Crit Rev Biochem Mol Biol. 2010. PMID: 20184396 Free PMC article. Review.
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an indispensible regulator of almost every cellular event from proliferation to migration. The central role …
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM …
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation.
Schumacher N, Rose-John S, Schmidt-Arras D. Schumacher N, et al. Int J Mol Sci. 2020 Jul 20;21(14):5133. doi: 10.3390/ijms21145133. Int J Mol Sci. 2020. PMID: 32698506 Free PMC article. Review.
Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also …
Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiator …
Domain integration of ADAM family proteins: Emerging themes from structural studies.
Seegar TC, Blacklow SC. Seegar TC, et al. Exp Biol Med (Maywood). 2019 Dec;244(17):1510-1519. doi: 10.1177/1535370219865901. Epub 2019 Jul 23. Exp Biol Med (Maywood). 2019. PMID: 31333048 Free PMC article. Review.
Fundamental questions about ADAM activation and substrate selection, however, still remain unanswered. Elucidating the biochemical and structural basis for ADAM regulation will be an exciting avenue of future research that should greatly advance our understanding of …
Fundamental questions about ADAM activation and substrate selection, however, still remain unanswered. Elucidating the biochemical an …
ADAM proteases: Emerging role and targeting of the non-catalytic domains.
Saha N, Robev D, Himanen JP, Nikolov DB. Saha N, et al. Cancer Lett. 2019 Dec 28;467:50-57. doi: 10.1016/j.canlet.2019.10.003. Epub 2019 Oct 5. Cancer Lett. 2019. PMID: 31593799 Free PMC article. Review.
ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. ...In this mini-review we describe t …
ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pa …
ADAM-15 disintegrin-like domain structure and function.
Lu D, Scully M, Kakkar V, Lu X. Lu D, et al. Toxins (Basel). 2010 Oct;2(10):2411-27. doi: 10.3390/toxins2102411. Epub 2010 Oct 19. Toxins (Basel). 2010. PMID: 22069559 Free PMC article. Review.
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integ …
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important funct …
Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma.
Chen YT, Lin CW, Chou YE, Su SC, Chang LC, Lee CY, Hsieh MJ, Yang SF. Chen YT, et al. J Cell Mol Med. 2023 Apr;27(8):1144-1152. doi: 10.1111/jcmm.17728. Epub 2023 Mar 22. J Cell Mol Med. 2023. PMID: 36946281 Free PMC article.
A disintegrin and metalloproteinase domain-containing protein 10 (ADAM-10) involves in the tumour progression, but the impacts of single-nucleotide polymorphism (SNP) of ADAM-10 on oral squamous cell carcinoma (OSCC) remain unclear. ...In conclusions, the ADAM …
A disintegrin and metalloproteinase domain-containing protein 10 (ADAM-10) involves in the tumour progression, but the impacts of sin …
41,381 results
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