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1

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.

Acharya K, Rashad AA, Moraca F, Klasse PJ, Moore JP, Abrams C, Chaiken I. Acharya K, et al. Among authors: Rashad AA. Proteins. 2017 May;85(5):843-851. doi: 10.1002/prot.25238. Epub 2017 Mar 11. Proteins. 2017. PMID: 28056499 Free PMC article.

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2

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, Cocklin S. Xu JP, et al. Among authors: Rashad AA. J Drug Des Res. 2018;5(2):1070. Epub 2018 Aug 13. J Drug Des Res. 2018. PMID: 30393786 Free PMC article.

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3

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency.

Meuser ME, Murphy MB, Rashad AA, Cocklin S. Meuser ME, et al. Among authors: Rashad AA. Molecules. 2018 Aug 3;23(8):1940. doi: 10.3390/molecules23081940. Molecules. 2018. PMID: 30081466 Free PMC article.

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4

Peptide triazole inactivators of HIV-1: how do they work and what is their potential?

Chaiken I, Rashad AA. Chaiken I, et al. Among authors: Rashad AA. Future Med Chem. 2015;7(17):2305-10. doi: 10.4155/fmc.15.152. Epub 2015 Nov 24. Future Med Chem. 2015. PMID: 26599515 Free PMC article. No abstract available.

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5

Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.

Rashad AA, Acharya K, Haftl A, Aneja R, Dick A, Holmes AP, Chaiken I. Rashad AA, et al. Org Biomol Chem. 2017 Sep 26;15(37):7770-7782. doi: 10.1039/c7ob01448a. Org Biomol Chem. 2017. PMID: 28770939 Free PMC article.

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6

Click Chemistry for Cyclic Peptide Drug Design.

Rashad AA. Rashad AA. Methods Mol Biol. 2019;2001:133-145. doi: 10.1007/978-1-4939-9504-2_8. Methods Mol Biol. 2019. PMID: 31134571

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7

Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface.

Rashad AA, Song LR, Holmes AP, Acharya K, Zhang S, Wang ZL, Gary E, Xie X, Pirrone V, Kutzler MA, Long YQ, Chaiken I. Rashad AA, et al. J Med Chem. 2018 Jun 14;61(11):5020-5033. doi: 10.1021/acs.jmedchem.8b00477. Epub 2018 Jun 1. J Med Chem. 2018. PMID: 29767965 Free PMC article.

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8

Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter.

Rashad AA, Kalyana Sundaram RV, Aneja R, Duffy C, Chaiken I. Rashad AA, et al. J Med Chem. 2015 Sep 24;58(18):7603-8. doi: 10.1021/acs.jmedchem.5b00935. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26331669 Free PMC article.

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9

Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity.

Kalyana Sundaram RV, Li H, Bailey L, Rashad AA, Aneja R, Weiss K, Huynh J, Bastian AR, Papazoglou E, Abrams C, Wrenn S, Chaiken I. Kalyana Sundaram RV, et al. Among authors: Rashad AA. Biochemistry. 2016 Jan 26;55(3):447-58. doi: 10.1021/acs.biochem.5b00936. Epub 2016 Jan 14. Biochemistry. 2016. PMID: 26713837 Free PMC article.

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10

Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer.

Parajuli B, Acharya K, Yu R, Ngo B, Rashad AA, Abrams CF, Chaiken IM. Parajuli B, et al. Among authors: Rashad AA. Biochemistry. 2016 Nov 8;55(44):6100-6114. doi: 10.1021/acs.biochem.6b00570. Epub 2016 Oct 27. Biochemistry. 2016. PMID: 27731975 Free PMC article.

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