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Substrate inhibition imposes fitness penalty at high protein stability.

Adkar BV, Bhattacharyya S, Gilson AI, Zhang W, Shakhnovich EI. Adkar BV, et al. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11265-11274. doi: 10.1073/pnas.1821447116. Epub 2019 May 16. Proc Natl Acad Sci U S A. 2019. PMID: 31097595 Free PMC article.

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Trade-offs between microbial growth phases lead to frequency-dependent and non-transitive selection.

Manhart M, Adkar BV, Shakhnovich EI. Manhart M, et al. Among authors: adkar bv. Proc Biol Sci. 2018 Feb 14;285(1872):20172459. doi: 10.1098/rspb.2017.2459. Proc Biol Sci. 2018. PMID: 29445020 Free PMC article.

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Accessibility of the Shine-Dalgarno Sequence Dictates N-Terminal Codon Bias in E. coli.

Bhattacharyya S, Jacobs WM, Adkar BV, Yan J, Zhang W, Shakhnovich EI. Bhattacharyya S, et al. Among authors: adkar bv. Mol Cell. 2018 Jun 7;70(5):894-905.e5. doi: 10.1016/j.molcel.2018.05.008. Epub 2018 Jun 7. Mol Cell. 2018. PMID: 29883608 Free PMC article.

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Optimization of lag phase shapes the evolution of a bacterial enzyme.

Adkar BV, Manhart M, Bhattacharyya S, Tian J, Musharbash M, Shakhnovich EI. Adkar BV, et al. Nat Ecol Evol. 2017 Apr 28;1(6):149. doi: 10.1038/s41559-017-0149. Nat Ecol Evol. 2017. PMID: 28812634 Free PMC article.

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Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype.

Bhattacharyya S, Bershtein S, Adkar BV, Woodard J, Shakhnovich EI. Bhattacharyya S, et al. Among authors: adkar bv. Mol Syst Biol. 2021 Jun;17(6):e10200. doi: 10.15252/msb.202110200. Mol Syst Biol. 2021. PMID: 34180142 Free PMC article.

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An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin.

Serebryany E, Woodard JC, Adkar BV, Shabab M, King JA, Shakhnovich EI. Serebryany E, et al. Among authors: adkar bv. J Biol Chem. 2016 Sep 2;291(36):19172-83. doi: 10.1074/jbc.M116.735977. Epub 2016 Jul 14. J Biol Chem. 2016. PMID: 27417136 Free PMC article.

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Protein model discrimination using mutational sensitivity derived from deep sequencing.

Adkar BV, Tripathi A, Sahoo A, Bajaj K, Goswami D, Chakrabarti P, Swarnkar MK, Gokhale RS, Varadarajan R. Adkar BV, et al. Structure. 2012 Feb 8;20(2):371-81. doi: 10.1016/j.str.2011.11.021. Structure. 2012. PMID: 22325784 Free article.

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Effect of signal peptide on stability and folding of Escherichia coli thioredoxin.

Singh P, Sharma L, Kulothungan SR, Adkar BV, Prajapati RS, Ali PS, Krishnan B, Varadarajan R. Singh P, et al. Among authors: adkar bv. PLoS One. 2013 May 7;8(5):e63442. doi: 10.1371/journal.pone.0063442. Print 2013. PLoS One. 2013. PMID: 23667620 Free PMC article.

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Role of water in the enzymatic catalysis: study of ATP + AMP → 2ADP conversion by adenylate kinase.

Adkar BV, Jana B, Bagchi B. Adkar BV, et al. J Phys Chem A. 2011 Apr 28;115(16):3691-7. doi: 10.1021/jp104787s. Epub 2010 Sep 13. J Phys Chem A. 2011. PMID: 20836529

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Stereochemical criteria for prediction of the effects of proline mutations on protein stability.

Bajaj K, Madhusudhan MS, Adkar BV, Chakrabarti P, Ramakrishnan C, Sali A, Varadarajan R. Bajaj K, et al. Among authors: adkar bv. PLoS Comput Biol. 2007 Dec;3(12):e241. doi: 10.1371/journal.pcbi.0030241. PLoS Comput Biol. 2007. PMID: 18069886 Free PMC article.

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