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Page 1
Multiple roles of ATP:cob(I)alamin adenosyltransferases in the conversion of B12 to coenzyme B12.
Mera PE, Escalante-Semerena JC. Mera PE, et al. Appl Microbiol Biotechnol. 2010 Sep;88(1):41-8. doi: 10.1007/s00253-010-2773-2. Epub 2010 Jul 31. Appl Microbiol Biotechnol. 2010. PMID: 20677021 Free PMC article. Review.
Our mechanistic understanding of the conversion of vitamin B(12) into coenzyme B(12) (a.k.a. adenosylcobalamin, AdoCbl) has been substantially advanced in recent years. Insights into the multiple roles played by ATP:cob(I)alamin adenosyltransferase (ACA) enzymes have emerg …
Our mechanistic understanding of the conversion of vitamin B(12) into coenzyme B(12) (a.k.a. adenosylcobalamin, AdoCbl) has been substantial …
Coordination Chemistry Controls Coenzyme B(12) Synthesis by Human Adenosine Triphosphate:Cob(I)alamin Adenosyltransferase.
Gouda H, Li Z, Ruetz M, Banerjee R. Gouda H, et al. Inorg Chem. 2023 Aug 14;62(32):12630-12633. doi: 10.1021/acs.inorgchem.3c02163. Epub 2023 Aug 1. Inorg Chem. 2023. PMID: 37526260
In this study, we reveal the sizable thermodynamic gain that accrues for human adenosine triphosphate (ATP):cob(I)alamin adenosyltransferase (or MMAB) by enforcing an unfavorable 4-c cob(II)alamin geometry. MMAB-bound cob(II)alamin is reduced to the supernucl …
In this study, we reveal the sizable thermodynamic gain that accrues for human adenosine triphosphate (ATP):cob(I)alamin adenosyltran …
Chlorocob(II)alamin Formation Which Enhances the Thiol Oxidase Activity of the B(12)-Trafficking Protein CblC.
Li Z, Greenhalgh ED, Twahir UT, Kallon A, Ruetz M, Warncke K, Brunold TC, Banerjee R. Li Z, et al. Inorg Chem. 2020 Nov 2;59(21):16065-16072. doi: 10.1021/acs.inorgchem.0c02653. Epub 2020 Oct 19. Inorg Chem. 2020. PMID: 33074687 Free PMC article.
CblC is a chaperone that catalyzes removal of the beta-axial ligand of cobalamin (or B(12)), generating cob(II)alamin in an early step in the cofactor trafficking pathway. Cob(II)alamin is subsequently partitioned to support cellular needs for the synthesis of activ …
CblC is a chaperone that catalyzes removal of the beta-axial ligand of cobalamin (or B(12)), generating cob(II)alamin in an early ste …
Reduction of Cob(III)alamin to Cob(II)alamin in Salmonella enterica serovar typhimurium LT2.
Fonseca MV, Escalante-Semerena JC. Fonseca MV, et al. J Bacteriol. 2000 Aug;182(15):4304-9. doi: 10.1128/JB.182.15.4304-4309.2000. J Bacteriol. 2000. PMID: 10894741 Free PMC article.
Enzyme-independent reduction of cob(III)alamin to cob(II)alamin by FMNH(2) occurred at a rate too fast to be measured. The thermodynamically unfavorable reduction of cob(II)alamin to cob(I)alamin was detectable by alkylation of the cob(I)alamin
Enzyme-independent reduction of cob(III)alamin to cob(II)alamin by FMNH(2) occurred at a rate too fast to be measured. The the …
Biochemical Characterization of the Methylmercaptopropionate:Cob(I)alamin Methyltransferase from Methanosarcina acetivorans.
Fu H, Goettge MN, Metcalf WW. Fu H, et al. J Bacteriol. 2019 May 22;201(12):e00130-19. doi: 10.1128/JB.00130-19. Print 2019 Jun 15. J Bacteriol. 2019. PMID: 30936368 Free PMC article.
MtpA catalyzes a robust methyl transfer reaction using free methylcob(III)alamin as the donor and mercaptopropionate (MPA) as the acceptor, with k(cat) of 0.315 s(-1) and apparent K(m) for MPA of 12 muM. ...Methylation of cob(I)alamin with methanol, dimethylsulfide, …
MtpA catalyzes a robust methyl transfer reaction using free methylcob(III)alamin as the donor and mercaptopropionate (MPA) as the acc …
Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions.
Gouda H, Mascarenhas R, Pillay S, Ruetz M, Koutmos M, Banerjee R. Gouda H, et al. J Biol Chem. 2021 Dec;297(6):101373. doi: 10.1016/j.jbc.2021.101373. Epub 2021 Oct 29. J Biol Chem. 2021. PMID: 34757128 Free PMC article.
Human ATP:cob(I)alamin adenosyltransferase (ATR) is a mitochondrial enzyme that catalyzes an adenosyl transfer to cob(I)alamin, synthesizing 5'-deoxyadenosylcobalamin (AdoCbl) or coenzyme B(12). ...All three mutations were found to weaken affinities for the cob(II) …
Human ATP:cob(I)alamin adenosyltransferase (ATR) is a mitochondrial enzyme that catalyzes an adenosyl transfer to cob(I)alamin
Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase.
Jarrett JT, Choi CY, Matthews RG. Jarrett JT, et al. Biochemistry. 1997 Dec 16;36(50):15739-48. doi: 10.1021/bi971987t. Biochemistry. 1997. PMID: 9398303
Methionine synthase catalyzes the transfer of a methyl group from methylcobalamin enzyme to homocysteine, generating methionine and cob(I)alamin enzyme, and then from methyltetrahydrofolate to cob(I)alamin enzyme, generating tetrahydrofolate and regenerating the met …
Methionine synthase catalyzes the transfer of a methyl group from methylcobalamin enzyme to homocysteine, generating methionine and cob(I) …
Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase.
Leal NA, Olteanu H, Banerjee R, Bobik TA. Leal NA, et al. J Biol Chem. 2004 Nov 12;279(46):47536-42. doi: 10.1074/jbc.M405449200. Epub 2004 Aug 30. J Biol Chem. 2004. PMID: 15347655 Free article.
Investigations also showed that purified recombinant human methionine synthase reductase (MSR) in combination with purified ATR can convert cob(II)alamin to AdoCbl in vitro. In this system, MSR reduced cob(II)alamin to cob(I)alamin that was adenosylated to Ad …
Investigations also showed that purified recombinant human methionine synthase reductase (MSR) in combination with purified ATR can convert …
The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme.
Jarrett JT, Hoover DM, Ludwig ML, Matthews RG. Jarrett JT, et al. Biochemistry. 1998 Sep 8;37(36):12649-58. doi: 10.1021/bi9808565. Biochemistry. 1998. PMID: 9730838
During this primary turnover cycle, the enzyme alternates between the active methylcobalamin and cob(I)alamin forms of the enzyme. Formation of the cob(II)alamin prosthetic group by oxidation of cob(I)alamin or photolysis of methylcobalamin renders the enzyme …
During this primary turnover cycle, the enzyme alternates between the active methylcobalamin and cob(I)alamin forms of the enzyme. Fo …
938 results