Structure-property relationships of benzyl-substituted urea-based ligands with Phe-Phe linker targeting prostate-specific membrane antigen labeled with gallium-68.
Butakova NS, Petrov SA, Uspenskaia AA, Zyk NY, Lunev AS, Petrosova KA, Mitrofanov IA, Rakhimov MG, Evteev SA, Ivanenkov YA, Demidova EA, Pokrovsky VS, Beloglazkina EK, Larenkov AA, Machulkin AE.
Butakova NS, et al.
Bioorg Chem. 2026 Sep 15;180:110122. doi: 10.1016/j.bioorg.2026.110122. Epub 2026 Jun 17.
Bioorg Chem. 2026.
PMID: 42314598
Here we prepared four DOTA-based PSMA-targeting conjugates that have a Glu-urea-Lys (DCL) as a vector and a constant -L-Phe-L-Phe-containing linker, while varying the epsilon-benzyl substituent (m-Cl, p-Br, p-COOH, or o-NO(2)). All conjugates were efficiently radiolabeled …
Here we prepared four DOTA-based PSMA-targeting conjugates that have a Glu-urea-Lys (DCL) as a vector and a constant -L-Phe-L-Phe-containing …