Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2019 1
2020 2
2021 2
2022 5
2023 4
2024 7
2025 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

24 results

Results by year

Filters applied: . Clear all
Page 1
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ. Runtsch MC, et al. Among authors: zotta a. Cell Metab. 2022 Mar 1;34(3):487-501.e8. doi: 10.1016/j.cmet.2022.02.002. Cell Metab. 2022. PMID: 35235776 Free article.
The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils.
Toller-Kawahisa JE, Hiroki CH, Silva CMS, Nascimento DC, Públio GA, Martins TV, Damasceno LEA, Veras FP, Viacava PR, Sukesada FY, Day EA, Zotta A, Ryan TAJ, Moreira da Silva R, Cunha TM, Lopes NP, Cunha FQ, O'Neill LAJ, Alves-Filho JC. Toller-Kawahisa JE, et al. Among authors: zotta a. Nat Commun. 2023 Jul 17;14(1):4280. doi: 10.1038/s41467-023-40021-6. Nat Commun. 2023. PMID: 37460614 Free PMC article.
Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase.
O'Carroll SM, Peace CG, Toller-Kawahisa JE, Min Y, Hooftman A, Charki S, Kehoe L, O'Sullivan MJ, Zoller A, Mcgettrick AF, Zotta A, Day EA, Simarro M, Armstrong N, Annes JP, O'Neill LAJ. O'Carroll SM, et al. Among authors: zotta a. Nat Metab. 2024 Nov;6(11):2060-2069. doi: 10.1038/s42255-024-01145-1. Epub 2024 Oct 15. Nat Metab. 2024. PMID: 39406969
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: zotta a. Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. Nat Commun. 2023. PMID: 37316487 Free PMC article.
Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine.
Toller-Kawahisa JE, Viacava PR, Palsson-McDermott EM, Nascimento DC, Cervantes-Silva MP, O'Carroll SM, Zotta A, Damasceno LEA, Públio GA, Forti P, Luiz JPM, Silva de Melo BM, Martins TV, Faça VM, Curtis A, Cunha TM, Cunha FQ, O'Neill LAJ, Alves-Filho JC. Toller-Kawahisa JE, et al. Among authors: zotta a. Cell Rep. 2025 Jan 28;44(1):115172. doi: 10.1016/j.celrep.2024.115172. Epub 2025 Jan 7. Cell Rep. 2025. PMID: 39772395 Free PMC article.
Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.
Zotta A, Toller-Kawahisa J, Palsson-McDermott EM, O'Carroll SM, Henry ÓC, Day EA, McGettrick AF, Ward RW, Ryan DG, Watson MA, Brand MD, Runtsch MC, Maitz K, Lueger A, Kargl J, Miljkovic JL, Lavelle EC, O'Neill LAJ. Zotta A, et al. Sci Adv. 2025 Jan 24;11(4):eadq7307. doi: 10.1126/sciadv.adq7307. Epub 2025 Jan 22. Sci Adv. 2025. PMID: 39841829 Free PMC article.
Neoadjuvant Immunotherapy in Head and Neck Cancers: A Paradigm Shift in Treatment Approach.
Zotta A, Marciano ML, Sabbatino F, Ottaiano A, Cascella M, Pontone M, Montano M, Calogero E, Longo F, Fasano M, Troiani T, Ciardiello F, Rampetta FR, Salzano G, Dell'Aversana Orabona G, Califano L, Ionna F, Perri F. Zotta A, et al. Biomedicines. 2024 Oct 14;12(10):2337. doi: 10.3390/biomedicines12102337. Biomedicines. 2024. PMID: 39457649 Free PMC article. Review.
Temozolomide based treatment in glioblastoma: 6 vs. 12 months.
Fasano M, Pirozzi M, De Falco V, Miceli CC, Farese S, Zotta A, Famiglietti V, Vitale P, Di Giovanni I, Brancati C, Carfora V, Solari D, Somma T, Cavallo LM, Cappabianca P, Conson M, Pacelli R, Ciardiello F, Addeo R. Fasano M, et al. Among authors: zotta a. Oncol Lett. 2024 Jul 2;28(3):418. doi: 10.3892/ol.2024.14551. eCollection 2024 Sep. Oncol Lett. 2024. PMID: 39006948 Free PMC article.
24 results