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A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways.
Chem Biol Interact. 2022 Sep 1;364:110056. doi: 10.1016/j.cbi.2022.110056. Epub 2022 Jul 21.
Chem Biol Interact. 2022.
PMID: 35872044
N-Glycoside of Indolo[2,3-a]pyrrolo[3,4-c]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction.
Kalitin N, Koroleva N, Lushnikova A, Babaeva M, Samoylenkova N, Savchenko E, Smirnova G, Borisova Y, Kostarev A, Karamysheva A, Pavlova G.
Kalitin N, et al. Among authors: kostarev a.
Pharmaceuticals (Basel). 2024 Dec 6;17(12):1642. doi: 10.3390/ph17121642.
Pharmaceuticals (Basel). 2024.
PMID: 39770484
Free PMC article.
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