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Page 1
Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.
Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms JA, Zuber S, Kottege L, Winter S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann AM, Meyer C, Ercanoglu MS, Cramer N, Munder A, Hallek M, Fätkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Klein F, Rybniker J. Simonis A, et al. Cell. 2023 Nov 9;186(23):5098-5113.e19. doi: 10.1016/j.cell.2023.10.002. Epub 2023 Nov 1. Cell. 2023. PMID: 37918395 Free article.
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages.
Simonis A, Theobald SJ, Koch AE, Mummadavarapu R, Mudler JM, Pouikli A, Göbel U, Acton R, Winter S, Albus A, Holzmann D, Albert MC, Hallek M, Walczak H, Ulas T, Koch M, Tessarz P, Hänsel-Hertsch R, Rybniker J. Simonis A, et al. Mol Syst Biol. 2025 Apr;21(4):341-360. doi: 10.1038/s44320-025-00093-6. Epub 2025 Mar 25. Mol Syst Biol. 2025. PMID: 40133533 Free PMC article.
The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.
Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alejandre Alcazar MA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, Bock F. Hamdorf M, et al. Among authors: simonis a. J Mol Cell Biol. 2024 Apr 4;15(10):mjad062. doi: 10.1093/jmcb/mjad062. J Mol Cell Biol. 2024. PMID: 37891014 Free PMC article.
Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19.
Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J. Theobald SJ, et al. Among authors: simonis a. EMBO Mol Med. 2021 Aug 9;13(8):e14150. doi: 10.15252/emmm.202114150. Epub 2021 Jun 16. EMBO Mol Med. 2021. PMID: 34133077 Free PMC article.
Disruption of CSF-1R signaling inhibits growth of AML with inv(16).
Simonis A, Russkamp NF, Mueller J, Wilk CM, Wildschut MHE, Myburgh R, Wildner-Verhey van Wijk N, Mueller R, Balabanov S, Valk PJM, Theocharides APA, Manz MG. Simonis A, et al. Blood Adv. 2021 Mar 9;5(5):1273-1277. doi: 10.1182/bloodadvances.2020003125. Blood Adv. 2021. PMID: 33651098 Free PMC article.
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