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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1872 1
1874 1
1877 1
1917 2
1918 1
1921 1
1937 1
1938 3
1939 2
1942 1
1945 1
1946 1
1948 5
1949 5
1950 6
1951 5
1952 9
1953 10
1954 7
1955 7
1956 7
1957 9
1958 8
1959 3
1960 6
1961 11
1962 13
1963 17
1964 33
1965 18
1966 18
1967 28
1968 19
1969 26
1970 35
1971 28
1972 37
1973 48
1974 43
1975 66
1976 65
1977 78
1978 86
1979 87
1980 118
1981 99
1982 96
1983 123
1984 147
1985 156
1986 126
1987 141
1988 173
1989 199
1990 211
1991 228
1992 234
1993 254
1994 282
1995 321
1996 332
1997 375
1998 414
1999 428
2000 498
2001 556
2002 646
2003 777
2004 864
2005 979
2006 1176
2007 1350
2008 1662
2009 1918
2010 2100
2011 2616
2012 2901
2013 3187
2014 3682
2015 4130
2016 4462
2017 4996
2018 5648
2019 6478
2020 8366
2021 10611
2022 11302
2023 11161
2024 3820

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89,933 results

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Page 1
Advances in the use of exosomes for the treatment of ALI/ARDS.
Liu C, Xiao K, Xie L. Liu C, et al. Front Immunol. 2022 Aug 9;13:971189. doi: 10.3389/fimmu.2022.971189. eCollection 2022. Front Immunol. 2022. PMID: 36016948 Free PMC article. Review.
Due to the lack of effective treatment strategies, most ALI/ARDS patients face a poor prognosis. The discovery of exosomes has created a promising prospect for the treatment of ALI/ARDS. ...The microRNA contained in exosomes can participate in intercellular communic …
Due to the lack of effective treatment strategies, most ALI/ARDS patients face a poor prognosis. The discovery of exosomes has create …
Targeting immunometabolism against acute lung injury.
Ning L, Shishi Z, Bo W, Huiqing L. Ning L, et al. Clin Immunol. 2023 Apr;249:109289. doi: 10.1016/j.clim.2023.109289. Epub 2023 Mar 12. Clin Immunol. 2023. PMID: 36918041 Free PMC article. Review.
Emerging evidence unveils the crucial roles of immunometabolism in inflammatory response and ALI. During ALI, both macrophages and lymphocytes undergo robust metabolic reprogramming and discrete epigenetic changes after activated. ...Finally, novel therapeutic targe …
Emerging evidence unveils the crucial roles of immunometabolism in inflammatory response and ALI. During ALI, both macrophages …
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury.
Zhou X, Liao Y. Zhou X, et al. Front Microbiol. 2021 Dec 23;12:779620. doi: 10.3389/fmicb.2021.779620. eCollection 2021. Front Microbiol. 2021. PMID: 35003009 Free PMC article. Review.
Sepsis is the leading indirect cause of ALI/ARDS in the intensive care unit (ICU). The pathogenesis of septic ALI/ARDS is complex and multifactorial. ...This article reviews the underlying mechanism of gut-lung crosstalk in septic ALI/ARDS....
Sepsis is the leading indirect cause of ALI/ARDS in the intensive care unit (ICU). The pathogenesis of septic ALI/ARDS is comp …
Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury.
Kumar V. Kumar V. Front Immunol. 2020 Aug 4;11:1722. doi: 10.3389/fimmu.2020.01722. eCollection 2020. Front Immunol. 2020. PMID: 32849610 Free PMC article. Review.
It highlights the immunological differences for the severity of bacterial sepsis-induced ALI as compared to the pneumonia-associated ALI. The immune-based differences between the Gram-positive and Gram-negative bacteria-induced pneumonia show different mechanisms to …
It highlights the immunological differences for the severity of bacterial sepsis-induced ALI as compared to the pneumonia-associated …
Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS.
Liu C, Xiao K, Xie L. Liu C, et al. Front Immunol. 2022 Aug 18;13:922702. doi: 10.3389/fimmu.2022.922702. eCollection 2022. Front Immunol. 2022. PMID: 36059534 Free PMC article. Review.
The development of ALI/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating the inflammatory response in ALI/ARDS. In this paper, we review the effects of autophagy in regulating macrophage function, discuss t …
The development of ALI/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating …
Air-liquid interface (ALI) impact on different respiratory cell cultures.
Silva S, Bicker J, Falcão A, Fortuna A. Silva S, et al. Eur J Pharm Biopharm. 2023 Mar;184:62-82. doi: 10.1016/j.ejpb.2023.01.013. Epub 2023 Jan 22. Eur J Pharm Biopharm. 2023. PMID: 36696943 Free article. Review.
Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. Until this day, with only exploratory results, no consensus has been reached regarding the validation of the ALI method, hampering da …
Different methodologies and a variety of materials have been used to induce ALI conditions in primary cells and numerous cell lines. …
Identification and validation of ferroptosis-related genes in lipopolysaccharide-induced acute lung injury.
Wang S, Song Y, Xu F, Liu H, Shen Y, Hu L, Fu Y, Zhu L. Wang S, et al. Cell Signal. 2023 Aug;108:110698. doi: 10.1016/j.cellsig.2023.110698. Epub 2023 May 5. Cell Signal. 2023. PMID: 37149072
CONCLUSION: We identified 86 potential ferroptosis-related genes of LPS-induced ALI through RNA-seq. Several pivotal ferroptosis-related genes involved in lipid metabolism and iron metabolism were implicated in ALI. This study may be helpful to expand our understand …
CONCLUSION: We identified 86 potential ferroptosis-related genes of LPS-induced ALI through RNA-seq. Several pivotal ferroptosis-rela …
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Lou L, Wang M, He J, Yang S, Meng F, Wang S, Jin X, Cai J, Cai C. Lou L, et al. Front Pharmacol. 2023 Mar 9;14:1067402. doi: 10.3389/fphar.2023.1067402. eCollection 2023. Front Pharmacol. 2023. PMID: 36969874 Free PMC article.
Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates. ...The Keap1-Nrf2/HO-1 pathway was upregulated by UA, which inhibited LPS-induced ALI and ferroptosis. ML385 inhibited UA's protective effect against LPS-induced ALI …
Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates. ...The Keap1-Nrf2/HO-1 pathway was upr …
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Deng HF, Yue LX, Wang NN, Zhou YQ, Zhou W, Liu X, Ni YH, Huang CS, Qiu LZ, Liu H, Tan HL, Tang XL, Wang YG, Ma ZC, Gao Y. Deng HF, et al. Front Pharmacol. 2021 Jan 21;11:624529. doi: 10.3389/fphar.2020.624529. eCollection 2020. Front Pharmacol. 2021. PMID: 33584308 Free PMC article.
Long-term administration of medicine-containing ALI was reported to be related to aristolochic acid nephropathy (AAN), which was attributed to ALI-induced nephrotoxicity. ...Therefore, this study explored the role of ferroptosis induced by mitochondrial iron overloa …
Long-term administration of medicine-containing ALI was reported to be related to aristolochic acid nephropathy (AAN), which was attr …
Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research.
Qu L, Li Y, Chen C, Yin T, Fang Q, Zhao Y, Lv W, Liu Z, Chen Y, Shen L. Qu L, et al. Cell Death Dis. 2022 Aug 6;13(8):686. doi: 10.1038/s41419-022-05134-8. Cell Death Dis. 2022. PMID: 35933468 Free PMC article.
The underlying mechanism of ALI is currently unclear. In this study, we aimed to confirm the hub genes associated with ALI and explore their functions and molecular mechanisms using bioinformatics methods. ...Among these DEGs, we identified two genes associated with …
The underlying mechanism of ALI is currently unclear. In this study, we aimed to confirm the hub genes associated with ALI and …
89,933 results
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