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9,177 results

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The following term was not found in PubMed: McLaughlin-Sheasby
Page 1
A structural basis for amylin receptor phenotype.
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. Cao J, et al. Science. 2022 Mar 25;375(6587):eabm9609. doi: 10.1126/science.abm9609. Epub 2022 Mar 25. Science. 2022. PMID: 35324283
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity-modifying proteins (RAMPs), AMY(1)R, AMY(2)R, and AMY(3)R. Selective AMYR agonists and dual AMYR/CTR agonists are being developed as obesity tre …
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity-modifying proteins (RAMPs …
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly.
Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, Ferrari C, Guerra UP, Paghera B, Muscio C, Bianchetti A, Volta GD, Turla M, Cotelli MS, Gennuso M, Prelle A, Zanetti O, Lussignoli G, Mirabile D, Bellandi D, Gentile S, Belotti G, Villani D, Harach T, Bolmont T, Padovani A, Boccardi M, Frisoni GB; INDIA-FBP Group. Cattaneo A, et al. Neurobiol Aging. 2017 Jan;49:60-68. doi: 10.1016/j.neurobiolaging.2016.08.019. Epub 2016 Aug 31. Neurobiol Aging. 2017. PMID: 27776263 Free article.
Amy+ patients showed higher levels of pro-inflammatory cytokines (IL-6, CXCL2, NLRP3, and IL-1beta) compared with both controls and with Amy- patients. A reduction of the anti-inflammatory cytokine IL-10 was observed in Amy+ versus Amy-. Amy+ sh …
Amy+ patients showed higher levels of pro-inflammatory cytokines (IL-6, CXCL2, NLRP3, and IL-1beta) compared with both controls and w …
Amy Gladfelter.
Gladfelter A. Gladfelter A. Curr Biol. 2025 Oct 6;35(19):R901-R902. doi: 10.1016/j.cub.2025.08.041. Curr Biol. 2025. PMID: 41056906
Interview with Amy Gladfelter, who studies how extreme cells are organized in space and time at Duke University....
Interview with Amy Gladfelter, who studies how extreme cells are organized in space and time at Duke University....
Amylin receptor subunit interactions are modulated by agonists and determine signaling.
Gostynska SE, Karim JA, Ford BE, Gordon PH, Babin KM, Inoue A, Lambert NA, Pioszak AA. Gostynska SE, et al. Sci Signal. 2025 Aug 19;18(900):eadt8127. doi: 10.1126/scisignal.adt8127. Epub 2025 Aug 19. Sci Signal. 2025. PMID: 40828907 Free PMC article.
By developing a biochemical assay that resolves the AMYR heterodimers and free subunits, we found that the AMY(1)R and AMY(2)R subunit distributions favored free CTR and RAMPs and that rat amylin promoted association of the constituent subunits of AMY(1)R and …
By developing a biochemical assay that resolves the AMYR heterodimers and free subunits, we found that the AMY(1)R and AMY(2)R …
Breast cancer and autism.
Radcliff L. Radcliff L. J Adv Pract Oncol. 2013 Mar;4(2):113-7. J Adv Pract Oncol. 2013. PMID: 25031990 Free PMC article. Review.
The APN is apprehensive about the ability to accomplish these tasks safely given Amy's limited capacity to participate. The APN is also concerned with how treatment will affect Amy's life. ...Should Amy receive chemotherapy or should Susan refuse treatment on …
The APN is apprehensive about the ability to accomplish these tasks safely given Amy's limited capacity to participate. The APN is al …
Sarah Amy Hill.
Hill T. Hill T. Cancer Inform. 2005;1(1):8. Cancer Inform. 2005. PMID: 19305626 Free PMC article. No abstract available.
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Cao J, Belousoff MJ, Danev R, Christopoulos A, Wootten D, Sexton PM. Cao J, et al. Biochemistry. 2024 May 7;63(9):1089-1096. doi: 10.1021/acs.biochem.4c00114. Epub 2024 Apr 11. Biochemistry. 2024. PMID: 38603770 Free PMC article.
However, a second CGRP-responsive receptor exists, the amylin (Amy) 1 receptor (AMY(1)R), yet its involvement in the pathology of migraine is poorly understood. ...Here, we present the structure of AMY(1)R in complex with CGRP and Gs protein and compare it wi …
However, a second CGRP-responsive receptor exists, the amylin (Amy) 1 receptor (AMY(1)R), yet its involvement in the pathology …
Amygdalin alleviates LPS-induced acute lung injury in mice by targeting CD5L/iNOS pathway.
Zhou B, Xue J, Wang J, Yu D, Zhou F, Duan JA, Niu Y, Wang H. Zhou B, et al. Mol Immunol. 2024 Dec;176:22-29. doi: 10.1016/j.molimm.2024.11.003. Epub 2024 Nov 18. Mol Immunol. 2024. PMID: 39561489
Through transcriptome sequencing, AMY was found to effectively reduce the mRNA level of CD5L in mice. In AAV-CD5L transfected mice, CD5L overexpression was found to block the protective effect of AMY in LPS-induced ALI mice. It was revealed that AMY inhibited …
Through transcriptome sequencing, AMY was found to effectively reduce the mRNA level of CD5L in mice. In AAV-CD5L transfected mice, C …
C3-targeted host-modulation approaches to oral inflammatory conditions.
Kajikawa T, Mastellos DC, Hasturk H, Kotsakis GA, Yancopoulou D, Lambris JD, Hajishengallis G. Kajikawa T, et al. Semin Immunol. 2022 Jan;59:101608. doi: 10.1016/j.smim.2022.101608. Epub 2022 Jun 9. Semin Immunol. 2022. PMID: 35691883 Review.
This review places emphasis on a promising periodontal host-modulation therapy targeting the complement system, namely the complement C3-targeting drug, AMY-101. AMY-101 has shown safety and efficacy in reducing gingival inflammation in a recent Phase 2a clinical st …
This review places emphasis on a promising periodontal host-modulation therapy targeting the complement system, namely the complement C3-tar …
Amylin receptor subunit interactions are modulated by agonists and determine signaling.
Gostynska SE, Karim JA, Ford BE, Gordon PH, Babin KM, Inoue A, Lambert NA, Pioszak AA. Gostynska SE, et al. bioRxiv [Preprint]. 2024 Oct 9:2024.10.09.617487. doi: 10.1101/2024.10.09.617487. bioRxiv. 2024. Update in: Sci Signal. 2025 Aug 19;18(900):eadt8127. doi: 10.1126/scisignal.adt8127. PMID: 39416010 Free PMC article. Updated. Preprint.
Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY(1)R, AMY(2)R, and AMY(3)R are heterodimers consisting of the G protein-coupled calcitonin receptor (CTR) paired with …
Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. …
9,177 results