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Year Number of Results
1982 1
1993 1
1995 1
1997 1
1998 1
2000 4
2001 1
2002 3
2003 3
2004 2
2005 2
2006 2
2007 5
2008 2
2009 5
2010 3
2011 4
2012 6
2013 9
2014 6
2015 4
2016 7
2017 5
2018 9
2019 8
2020 5
2021 4
2022 8
2023 7
2024 3

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110 results

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Page 1
Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease.
Bode M, Diemer JN, Luu TV, Ehnert N, Teigeler T, Wiech T, Lindenmeyer MT, Herrnstadt GR, Bülow J, Huber TB, Tomas NM, Wenzel UO. Bode M, et al. Br J Pharmacol. 2023 Sep;180(18):2412-2435. doi: 10.1111/bph.16097. Epub 2023 May 18. Br J Pharmacol. 2023. PMID: 37076314
Renal single cell RNA sequence data from normotensive and hypertensive patients confirmed expression of C3 in different cellular compartments of the kidney. In angiotensin II (Ang II) induced hypertension renal C3 expression was up-regulated. ...Down-regulati …
Renal single cell RNA sequence data from normotensive and hypertensive patients confirmed expression of C3 in different cellular comp …
Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.
Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra AB, Jung JJ, Kukreja G, Zhang J, Lakheram D, Kim SK, Humphrey JD, Sadeghi MM. Salarian M, et al. Circ Res. 2023 Feb 17;132(4):432-448. doi: 10.1161/CIRCRESAHA.122.322096. Epub 2023 Jan 24. Circ Res. 2023. PMID: 36691905 Free PMC article.
METHODS: Apoe(-/-) and Mmp12(-/-)/Apoe(-/-) mice were infused with Ang II (angiotensin). Expression of neutrophil extracellular traps (NETs) markers and complement component 3 (C3) levels were evaluated by immunostaining in aortas of surviving animals. ...Treatment …
METHODS: Apoe(-/-) and Mmp12(-/-)/Apoe(-/-) mice were infused with Ang II (angiotensin). Expression of neutrophil extracellular traps …
Identification of an APOE ε4-specific blood-based molecular pathway for Alzheimer's disease risk.
Tao Q, Zhang C, Mercier G, Lunetta K, Ang TFA, Akhter-Khan S, Zhang Z, Taylor A, Killiany RJ, Alosco M, Mez J, Au R, Zhang X, Farrer LA, Qiu WWQ; Alzheimer's Disease Neuroimaging Initiative. Tao Q, et al. Alzheimers Dement (Amst). 2023 Oct 16;15(4):e12490. doi: 10.1002/dad2.12490. eCollection 2023 Oct-Dec. Alzheimers Dement (Amst). 2023. PMID: 37854772 Free PMC article.
Three proteins from this module, C-reactive protein (CRP), complement C3, and complement factor H (CFH), had dose-dependent associations with CSF p-tau and cognitive impairment only in APOE epsilon4 homozygotes. ...DISCUSSION: The study identifies the APOE epsilon4-specifi …
Three proteins from this module, C-reactive protein (CRP), complement C3, and complement factor H (CFH), had dose-dependent associati …
Computational design of substrate selective inhibition.
Da'adoosh B, Kaito K, Miyashita K, Sakaguchi M, Goldblum A. Da'adoosh B, et al. PLoS Comput Biol. 2020 Mar 20;16(3):e1007713. doi: 10.1371/journal.pcbi.1007713. eCollection 2020 Mar. PLoS Comput Biol. 2020. PMID: 32196495 Free PMC article.
Among those are Thyrotropin Releasing Hormone (TRH) and Angiotensin-III (Ang-III), differing in both their binding (Km) and in turnover (kcat). ...Two molecules out of these 20, one with a high score in the ISE model, the other successful in the pharmacophore model, were c …
Among those are Thyrotropin Releasing Hormone (TRH) and Angiotensin-III (Ang-III), differing in both their binding (Km) and in turnov …
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y. Lyu L, et al. J Cell Mol Med. 2021 Mar;25(6):3136-3148. doi: 10.1111/jcmm.16304. Epub 2021 Feb 9. J Cell Mol Med. 2021. PMID: 33560596 Free PMC article.
Long-term poorly controlled myocardial hypertrophy often leads to heart failure and sudden death. Activation of ras-related C3 botulinum toxin substrate 1 (RAC1) by angiotensin II (Ang II) plays a pivotal role in myocardial hypertrophy. ...In vitro, SCO treatment bl …
Long-term poorly controlled myocardial hypertrophy often leads to heart failure and sudden death. Activation of ras-related C3 botuli …
A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11.
Welches WR, Brosnihan KB, Ferrario CM. Welches WR, et al. Life Sci. 1993;52(18):1461-80. doi: 10.1016/0024-3205(93)90108-f. Life Sci. 1993. PMID: 8387132 Review.
The discovery of angiotensin-(1-7) [Ang-(1-7)] as a bioactive Ang II fragment of the renin-angiotensin system (RAS) alters the current understanding of the enzymatic components that comprise the RAS cascade. Two neutral endopeptidases, prolyl endopeptidase (E.C. 3.4 …
The discovery of angiotensin-(1-7) [Ang-(1-7)] as a bioactive Ang II fragment of the renin-angiotensin system (RAS) alters the …
Bone Density Distribution in the Cervical Spine.
Lovecchio F, Ang B, Louie PK, Chaudary C, Shah SP, Punyala A, Yao YC, Steinhaus M, McCarthy MH, Huang R, Lebl D, Lafage V, Albert TJ, Iyer S, Qureshi S, Kim HJ. Lovecchio F, et al. Global Spine J. 2024 Jan;14(1):169-176. doi: 10.1177/21925682221098965. Epub 2022 Apr 29. Global Spine J. 2024. PMID: 35485915 Free PMC article.
Measurements were performed in each vertebral body (C2-T1; mid-axial, anterior-axial, posterior-axial, mid-coronal, and mid-sagittal) and 2 regions of the lateral masses (C3-C6; mid-cor, mid-sag). To evaluate reliability, 6 observers each measured 355 HU values, inter-rela …
Measurements were performed in each vertebral body (C2-T1; mid-axial, anterior-axial, posterior-axial, mid-coronal, and mid-sagittal) and 2 …
Energy Transfer Photocatalytic Radical Rearrangement in N-Indolyl Carbonates.
Bera M, Hwang HS, Um TW, Oh SM, Shin S, Cho EJ. Bera M, et al. Org Lett. 2022 Mar 11;24(9):1774-1779. doi: 10.1021/acs.orglett.2c00085. Epub 2022 Mar 1. Org Lett. 2022. PMID: 35230112
Upon photoexcitation, homolytic N-O bond cleavage of N-indolyl carbonate in the presence of an Ir complex produced N- and O-centered radicals. The high spin density at the C3 position of indole led to radical recombination with the O-centered radical, affording valuable 3- …
Upon photoexcitation, homolytic N-O bond cleavage of N-indolyl carbonate in the presence of an Ir complex produced N- and O-centered radical …
110 results