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109 results

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The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment.
Czarnota-Łydka K, Kucwaj-Brysz K, Mordyl B, Głuch-Lutwin M, Karcz T, Jastrzębska-Więsek M, Partyka A, Dąbrowska M, Satała G, Sudoł-Tałaj S, Brunetti L, de Candia M, Purgatorio R, Cerini M, Piemontese L, Podlewska S, Latacz G, Starek M, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: partyka a. Eur J Med Chem. 2025 Nov 15;298:118026. doi: 10.1016/j.ejmech.2025.118026. Epub 2025 Aug 5. Eur J Med Chem. 2025. PMID: 40774068 Free article.
Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity.
Sniecikowska J, Gluch-Lutwin M, Bucki A, Gryzlo B, Wieckowski K, Godyn J, Wieckowska A, Siwek A, Jastrzebska-Wiesek M, Partyka A, Cios A, Wesolowska A, Newman-Tancredi A, Kolaczkowski M. Sniecikowska J, et al. Among authors: partyka a. J Med Chem. 2025 May 8;68(9):9706-9722. doi: 10.1021/acs.jmedchem.5c00484. Epub 2025 Apr 23. J Med Chem. 2025. PMID: 40267318 Free PMC article.
Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson's disease and its comorbidities.
Zajdel P, Matłoka M, Konieczny J, Kos T, Lammers JC, Cavalco NG, Clark AA, Lenda T, Satała G, Canale V, Grychowska K, Krawczyk M, Nikiforuk A, Partyka A, Jastrzębska-Więsek M, Berghauzen-Maciejewska K, Biała D, Janicka M, Janusz A, Piast R, Mulewski K, Smuga D, Pieczykolan J, Wieczorek M, Moszczyński-Pętkowski R, Dubiel K, Ossowska K, Bojarski AJ, Kamiński K, McCorvy JD, Popik P. Zajdel P, et al. Among authors: partyka a. J Pharmacol Exp Ther. 2025 Feb;392(2):100055. doi: 10.1016/j.jpet.2024.100055. Epub 2024 Dec 9. J Pharmacol Exp Ther. 2025. PMID: 40023605 Free article.
Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.
Dinas PC, Nintou E, Vliora M, Pravednikova AE, Sakellariou P, Witkowicz A, Kachaev ZM, Kerchev VV, Larina SN, Cotton J, Kowalska A, Gkiata P, Bargiota A, Khachatryan ZA, Hovhannisyan AA, Antonosyan MA, Margaryan S, Partyka A, Bogdanski P, Szulinska M, Kregielska-Narozna M, Czepczyński R, Ruchała M, Tomkiewicz A, Yepiskoposyan L, Karabon L, Shidlovskii Y, Metsios GS, Flouris AD. Dinas PC, et al. Among authors: partyka a. PLoS One. 2022 Apr 28;17(4):e0266386. doi: 10.1371/journal.pone.0266386. eCollection 2022. PLoS One. 2022. PMID: 35482655 Free PMC article.
Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models.
Partyka A, Gołębiowska J, Marciniec K, Canale V, Trybała W, Satała G, Grychowska K, Jastrzębska-Więsek M, Bojarski AJ, Nikiforuk A, Daniel WA, Wesołowska A, Zajdel P, Popik P. Partyka A, et al. Pharmacol Rep. 2025 Jun;77(3):689-702. doi: 10.1007/s43440-025-00713-w. Epub 2025 Mar 11. Pharmacol Rep. 2025. PMID: 40064751
Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties.
Canale V, Blicharz-Futera K, Bijata M, Cavalco NG, Partyka A, Stefaniak M, Kamiński M, Satała G, Warszycki D, Lanham JK, Gołębiowska J, Gawlik M, Smolik M, Bijata K, Jastrzębska-Więsek M, Kurczab R, Bojarski AJ, Walczak M, McCorvy JD, Włodarczyk J, Popik P, Zajdel P. Canale V, et al. Among authors: partyka a. Eur J Med Chem. 2026 Jan 15;302(Pt 3):118369. doi: 10.1016/j.ejmech.2025.118369. Epub 2025 Nov 21. Eur J Med Chem. 2026. PMID: 41289819
109 results