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Year Number of Results
2003 1
2005 1
2006 1
2007 3
2008 4
2009 2
2011 1
2012 2
2014 1
2015 2
2016 3
2017 2
2018 3
2019 2
2020 5
2021 0
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28 results
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Page 1
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
Szabó KE, Kyriakis E, Psarra AG, Karra AG, Sipos Á, Docsa T, Stravodimos GA, Katsidou E, Skamnaki VT, Liggri PGV, Zographos SE, Mándi A, Király SB, Kurtán T, Leonidas DD, Somsák L. Szabó KE, et al. Among authors: psarra ag. J Med Chem. 2019 Jul 11;62(13):6116-6136. doi: 10.1021/acs.jmedchem.9b00356. Epub 2019 Jun 28. J Med Chem. 2019. PMID: 31251604
Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
Drakou CE, Gardeli C, Tsialtas I, Alexopoulos S, Mallouchos A, Koulas SM, Tsagkarakou AS, Asimakopoulos D, Leonidas DD, Psarra AG, Skamnaki VT. Drakou CE, et al. Among authors: psarra ag. J Agric Food Chem. 2020 Sep 16;68(37):10191-10199. doi: 10.1021/acs.jafc.0c04205. Epub 2020 Sep 7. J Agric Food Chem. 2020. PMID: 32840370
The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Kyriakis E, Karra AG, Papaioannou O, Solovou T, Skamnaki VT, Liggri PGV, Zographos SE, Szennyes E, Bokor É, Kun S, Psarra AG, Somsák L, Leonidas DD. Kyriakis E, et al. Among authors: psarra ag. Bioorg Med Chem. 2020 Jan 1;28(1):115196. doi: 10.1016/j.bmc.2019.115196. Epub 2019 Nov 14. Bioorg Med Chem. 2020. PMID: 31767404
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Chetter BA, Kyriakis E, Barr D, Karra AG, Katsidou E, Koulas SM, Skamnaki VT, Snape TJ, Psarra AG, Leonidas DD, Hayes JM. Chetter BA, et al. Among authors: psarra ag. Bioorg Chem. 2020 Sep;102:104003. doi: 10.1016/j.bioorg.2020.104003. Epub 2020 Jun 10. Bioorg Chem. 2020. PMID: 32771768
Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase.
Stravodimos GA, Kantsadi AL, Apostolou A, Kyriakis E, Kafaski-Kanelli VN, Solovou T, Gatzona P, Liggri PGV, Theofanous S, Gorgogietas VA, Kissa A, Psachoula C, Lemonakis A, Chatzileontiadou DSM, Psarra AG, Skamnaki VT, Haroutounian SA, Leonidas DD. Stravodimos GA, et al. Among authors: psarra ag. Curr Drug Discov Technol. 2018;15(1):41-53. doi: 10.2174/1570163814666170619091736. Curr Drug Discov Technol. 2018. PMID: 28625148
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