Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
He S, Chu X, Wu Y, Jiang J, Fang P, Chen Y, Liu Y, Qiu Z, Xiao Y, Li Z, Pan D, Zhang Q, Xie H, Xing S, Feng F, Liu W, Guo Q, Zhao L, Yang P, Sun H.
He S, et al.
J Med Chem. 2023 Jul 27;66(14):9537-9560. doi: 10.1021/acs.jmedchem.3c00213. Epub 2023 Jul 6.
J Med Chem. 2023.
PMID: 37409679
The catalytic activity of the enzyme has been recognized as one of the important factors in inducing anthracycline (ANT) resistance in cancer cells. Inhibition of AKR1C3 activity may provide a promising approach to restore the chemosensitivity of ANT-resistant cance …
The catalytic activity of the enzyme has been recognized as one of the important factors in inducing anthracycline (ANT) resistance i …