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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
Zhang J, Bodenko V, Larkina M, Bezverkhniaia E, Xu T, Liao Y, Abouzayed A, Plotnikov E, Tretyakova M, Yuldasheva F, Belousov MV, Orlova A, Tolmachev V, Gräslund T, Vorobyeva A. Zhang J, et al. Among authors: vorobyeva a. J Control Release. 2024 Jun;370:468-478. doi: 10.1016/j.jconrel.2024.04.051. Epub 2024 May 8. J Control Release. 2024. PMID: 38697314 Free article.
Evaluation of a novel 177Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile.
Liu Y, Oroujeni M, Liao Y, Vorobyeva A, Bodenko V, Orlova A, Konijnenberg M, Carlqvist M, Wahlberg E, Loftenius A, Frejd FY, Tolmachev V. Liu Y, et al. Among authors: vorobyeva a. Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):4038-4048. doi: 10.1007/s00259-024-06840-5. Epub 2024 Jul 15. Eur J Nucl Med Mol Imaging. 2024. PMID: 39008065 Free PMC article.
Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle.
Garousi J, von Witting E, Borin J, Vorobyeva A, Altai M, Vorontsova O, Konijnenberg MW, Oroujeni M, Orlova A, Tolmachev V, Hober S. Garousi J, et al. Among authors: vorobyeva a. Biomaterials. 2021 Jan;266:120381. doi: 10.1016/j.biomaterials.2020.120381. Epub 2020 Oct 17. Biomaterials. 2021. PMID: 33120197 Free article.
68 results