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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1908 1
1950 3
1951 1
1952 2
1954 1
1955 1
1969 2
1970 1
1972 1
1974 2
1975 1
1976 2
1978 1
1980 1
1981 1
1982 7
1983 8
1984 10
1985 7
1986 9
1987 12
1988 10
1989 5
1990 2
1991 11
1992 7
1993 4
1994 6
1995 15
1996 24
1997 39
1998 44
1999 44
2000 33
2001 39
2002 43
2003 42
2004 41
2005 38
2006 39
2007 44
2008 49
2009 36
2010 55
2011 39
2012 58
2013 62
2014 69
2015 59
2016 49
2017 51
2018 56
2019 71
2020 69
2021 84
2022 81
2023 101
2024 89

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1,538 results

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The following term was not found in PubMed: Gorooei
Page 1
Role of platelets and platelet receptors in cancer metastasis.
Schlesinger M. Schlesinger M. J Hematol Oncol. 2018 Oct 11;11(1):125. doi: 10.1186/s13045-018-0669-2. J Hematol Oncol. 2018. PMID: 30305116 Free PMC article. Review.
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on platelet adhesion receptors and their role in metastasis. Immunoreceptor tyrosine-based activation motif (ITA …
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on plat …
T cell activation.
Smith-Garvin JE, Koretzky GA, Jordan MS. Smith-Garvin JE, et al. Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706. Annu Rev Immunol. 2009. PMID: 19132916 Free PMC article. Review.
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory mole …
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings …
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. Feucht J, et al. Nat Med. 2019 Jan;25(1):82-88. doi: 10.1038/s41591-018-0290-5. Epub 2018 Dec 17. Nat Med. 2019. PMID: 30559421 Free PMC article.
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and differentiation. Here, we show that CARs encoding a single immunoreceptor tyrosine-based activation motif …
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and …
A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Burkard P, Schonhart C, Vögtle T, Köhler D, Tang L, Johnson D, Hemmen K, Heinze KG, Zarbock A, Hermanns HM, Rosenberger P, Nieswandt B. Burkard P, et al. Blood. 2023 Oct 26;142(17):1463-1477. doi: 10.1182/blood.2023019940. Blood. 2023. PMID: 37441848
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that the immunoreceptor tyrosine-based activation motif-coupled immunoglobulin-like platelet receptor, glycopro …
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that t …
Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI, Nieswandt B. Mammadova-Bach E, et al. Blood. 2020 Apr 2;135(14):1146-1160. doi: 10.1182/blood.2019002649. Blood. 2020. PMID: 32040544 Free article.
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin that triggers platelet activation through immunoreceptor tyrosine-based activation motif (ITAM) signaling and thereby regulates diverse functions, including pl …
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin that triggers platelet activation through immunorec …
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides.
Gaud G, Achar S, Bourassa FXP, Davies J, Hatzihristidis T, Choi S, Kondo T, Gossa S, Lee J, Juneau P, Taylor N, Hinrichs CS, McGavern DB, François P, Altan-Bonnet G, Love PE. Gaud G, et al. Nat Immunol. 2023 Dec;24(12):2121-2134. doi: 10.1038/s41590-023-01663-2. Epub 2023 Nov 9. Nat Immunol. 2023. PMID: 37945821
The T cell antigen receptor (TCR) contains ten immunoreceptor tyrosine-based activation motif (ITAM) signaling sequences distributed within six CD3 subunits; however, the reason for such structural complexity and multiplicity is unclear. ...
The T cell antigen receptor (TCR) contains ten immunoreceptor tyrosine-based activation motif (ITAM) sign …
Platelet ITAM signaling.
Bergmeier W, Stefanini L. Bergmeier W, et al. Curr Opin Hematol. 2013 Sep;20(5):445-50. doi: 10.1097/MOH.0b013e3283642267. Curr Opin Hematol. 2013. PMID: 23921514 Review.
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In contrast, deficiency in the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors glyco …
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In …
RBP-J and ITAM crosstalk.
Zhao B. Zhao B. Oncotarget. 2015 Nov 3;6(34):35135-6. doi: 10.18632/oncotarget.6034. Oncotarget. 2015. PMID: 26459387 Free PMC article. No abstract available.
FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms.
Simpson AP, Roghanian A, Oldham RJ, Chan HTC, Penfold CA, Kim HJ, Inzhelevskaya T, Mockridge CI, Cox KL, Bogdanov YD, James S, Tutt AL, Rycroft D, Morley P, Dahal LN, Teige I, Frendeus B, Beers SA, Cragg MS. Simpson AP, et al. Cell Rep. 2022 Jul 19;40(3):111099. doi: 10.1016/j.celrep.2022.111099. Cell Rep. 2022. PMID: 35858562 Free PMC article.
Dogma suggests inhibition is mediated through the FcgammaRIIB immunoreceptor tyrosine-based inhibition motif (ITIM), negatively regulating immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling from …
Dogma suggests inhibition is mediated through the FcgammaRIIB immunoreceptor tyrosine-based inhibition motif (IT …
The TREM-1/DAP12 pathway.
Tessarz AS, Cerwenka A. Tessarz AS, et al. Immunol Lett. 2008 Mar 15;116(2):111-6. doi: 10.1016/j.imlet.2007.11.021. Epub 2007 Dec 26. Immunol Lett. 2008. PMID: 18192027 Review.
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer (NK) cells, monocytes, and neutrophils. ...
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITA …
1,538 results