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Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity.
Dos Santos Souza C, Grangeiro MS, Lima Pereira EP, Dos Santos CC, da Silva AB, Sampaio GP, Ribeiro Figueiredo DD, David JM, David JP, da Silva VDA, Butt AM, Lima Costa S. Dos Santos Souza C, et al. Among authors: butt am. Neurotoxicology. 2018 Mar;65:85-97. doi: 10.1016/j.neuro.2018.02.001. Epub 2018 Feb 6. Neurotoxicology. 2018. PMID: 29425760
Phytoestrogen Agathisflavone Ameliorates Neuroinflammation-Induced by LPS and IL-1β and Protects Neurons in Cocultures of Glia/Neurons.
de Almeida MMA, Souza CDS, Dourado NS, da Silva AB, Ferreira RS, David JM, David JP, Costa MFD, da Silva VDA, Butt AM, Costa SL. de Almeida MMA, et al. Among authors: butt am. Biomolecules. 2020 Apr 7;10(4):562. doi: 10.3390/biom10040562. Biomolecules. 2020. PMID: 32272581 Free PMC article.
Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds.
Silva JHCE, Ferreira RS, Pereira EP, Braga-de-Souza S, Almeida MMA, Santos CCD, Butt AM, Caiazzo E, Capasso R, Silva VDAD, Costa SL. Silva JHCE, et al. Among authors: butt am. Molecules. 2020 Jul 27;25(15):3394. doi: 10.3390/molecules25153394. Molecules. 2020. PMID: 32726999 Free PMC article. Review.
The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination.
de Almeida MMA, Pieropan F, de Mattos Oliveira L, Dos Santos Junior MC, David JM, David JP, da Silva VDA, Dos Santos Souza C, Costa SL, Butt AM. de Almeida MMA, et al. Among authors: butt am. Pharmacol Res. 2020 Sep;159:104997. doi: 10.1016/j.phrs.2020.104997. Epub 2020 Jun 11. Pharmacol Res. 2020. PMID: 32534098 Free article.
Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer's Disease.
Dourado NS, Souza CDS, de Almeida MMA, Bispo da Silva A, Dos Santos BL, Silva VDA, De Assis AM, da Silva JS, Souza DO, Costa MFD, Butt AM, Costa SL. Dourado NS, et al. Among authors: butt am. Front Aging Neurosci. 2020 May 15;12:119. doi: 10.3389/fnagi.2020.00119. eCollection 2020. Front Aging Neurosci. 2020. PMID: 32499693 Free PMC article.
Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury.
de Amorim VCM, Júnior MSO, da Silva AB, David JM, David JPL, de Fátima Dias Costa M, Butt AM, da Silva VDA, Costa SL. de Amorim VCM, et al. Among authors: butt am. Naunyn Schmiedebergs Arch Pharmacol. 2020 Oct;393(10):1921-1930. doi: 10.1007/s00210-020-01905-2. Epub 2020 May 22. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 32444988