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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
Sakkestad ST, Steinsland H, Skrede S, Lillebø K, Skutlaberg DH, Guttormsen AB, Zavialov A, Paavilainen S, Søyland H, Sævik M, Heien AR, Tellevik MG, Barry E, Langeland N, Sommerfelt H, Hanevik K. Sakkestad ST, et al. Among authors: heien ar. PLoS Negl Trop Dis. 2019 Oct 30;13(10):e0007823. doi: 10.1371/journal.pntd.0007823. eCollection 2019 Oct. PLoS Negl Trop Dis. 2019. PMID: 31665141 Free PMC article. Clinical Trial.
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681.
Todnem Sakkestad S, Steinsland H, Skrede S, Kleppa E, Lillebø K, Sævik M, Søyland H, Rykkje Heien A, Gjerde Tellevik M, Barry EM, Sommerfelt H, Hanevik K. Todnem Sakkestad S, et al. Among authors: rykkje heien a. Pathogens. 2019 Jun 22;8(2):84. doi: 10.3390/pathogens8020084. Pathogens. 2019. PMID: 31234485 Free PMC article.