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A genome-wide atlas of human cell morphology.
Ramezani M, Weisbart E, Bauman J, Singh A, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Leardini E, Jetley G, Pagnotta J, Haghighi M, Batista TM, Pérez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. Ramezani M, et al. Nat Methods. 2025 Mar;22(3):621-633. doi: 10.1038/s41592-024-02537-7. Epub 2025 Jan 27. Nat Methods. 2025. PMID: 39870862 Free PMC article.
Using this atlas, we identify the poorly characterized disease-associated TMEM251/LYSET as a Golgi-resident transmembrane protein essential for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. In sum, this perturbation atlas and screening platform rep …
Using this atlas, we identify the poorly characterized disease-associated TMEM251/LYSET as a Golgi-resident transmembrane protein ess …
A genome-wide atlas of human cell morphology.
Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Haghighi M, Batista TM, Pérez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. Ramezani M, et al. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552164. doi: 10.1101/2023.08.06.552164. bioRxiv. 2023. Update in: Nat Methods. 2025 Mar;22(3):621-633. doi: 10.1038/s41592-024-02537-7. PMID: 37609130 Free PMC article. Updated. Preprint.
Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-scale genotype-phenotype maps comprising >20,000 single-gene CRISPR-Cas9-based knockout experiments in >30 million cells. ...In sum, our atl …
Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-scale gen …
Preliminary biomechanical cadaver study investigating a new load-sharing knee implant.
Saeidi M, Kelly PA, Netzel C, Scadeng M, Kumar P, Prendergast D, Neitzert T, Ramezani M. Saeidi M, et al. J Exp Orthop. 2021 Aug 14;8(1):61. doi: 10.1186/s40634-021-00379-2. J Exp Orthop. 2021. PMID: 34392435 Free PMC article.
This device could be as effective as, for example, the Atlas system, but without some complications seen with other devices; this would need to be validated through similar results being observed in an appropriate in vivo study....
This device could be as effective as, for example, the Atlas system, but without some complications seen with other devices; this wo …
Verification of multi-structure targeting in chronic microelectrode brain recordings from CT scans.
Censoni L, Halje P, Axelsson J, Skovgård K, Ramezani A, Malinina E, Petersson P. Censoni L, et al. J Neurosci Methods. 2022 Dec 1;382:109719. doi: 10.1016/j.jneumeth.2022.109719. Epub 2022 Oct 3. J Neurosci Methods. 2022. PMID: 36195238 Free article.
NEW METHOD: To mitigate this problem, we have developed a method to programmatically segment the trajectory of electrodes arranged in larger arrays from acquired CT-images and thereby determine the position of individual recording tips with high spatial resolution, while also all …
NEW METHOD: To mitigate this problem, we have developed a method to programmatically segment the trajectory of electrodes arranged in larger …
Dysfunction of the MDM2/p53 axis is linked to premature aging.
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C. Lessel D, et al. J Clin Invest. 2017 Oct 2;127(10):3598-3608. doi: 10.1172/JCI92171. Epub 2017 Aug 28. J Clin Invest. 2017. PMID: 28846075 Free PMC article.
Investigation of olfactory receptor family 51 subfamily j member 1 (OR51J1) gene susceptibility as a potential breast cancer-associated biomarker.
Asadi M, Ahmadi N, Ahmadvand S, Jafari AA, Safaei A, Erfani N, Ramezani A. Asadi M, et al. PLoS One. 2021 Feb 10;16(2):e0246752. doi: 10.1371/journal.pone.0246752. eCollection 2021. PLoS One. 2021. PMID: 33566867 Free PMC article.
Here, a statistical approach using complete data from the human protein atlas database was used to evaluate the potential of OR51J1 gene as a cancer-associated biomarker. ...
Here, a statistical approach using complete data from the human protein atlas database was used to evaluate the potential of OR51J1 g …
Temporal-lobe morphology differs between healthy adolescents and those with early-onset of depression.
Ramezani M, Johnsrude I, Rasoulian A, Bosma R, Tong R, Hollenstein T, Harkness K, Abolmaesumi P. Ramezani M, et al. Neuroimage Clin. 2014 Aug 14;6:145-55. doi: 10.1016/j.nicl.2014.08.007. eCollection 2014. Neuroimage Clin. 2014. PMID: 25379426 Free PMC article.
The hippocampus, parahippocampal gyrus, putamen, and superior, inferior and middle temporal gyri in both hemispheres of the brain were automatically segmented using the LONI Probabilistic Brain Atlas (Shattuck et al., 2008) in MNI space. Points on the surface of each struc …
The hippocampus, parahippocampal gyrus, putamen, and superior, inferior and middle temporal gyri in both hemispheres of the brain were autom …
Pronto: A Multi-Sensor State Estimator for Legged Robots in Real-World Scenarios.
Camurri M, Ramezani M, Nobili S, Fallon M. Camurri M, et al. Front Robot AI. 2020 Jun 5;7:68. doi: 10.3389/frobt.2020.00068. eCollection 2020. Front Robot AI. 2020. PMID: 33501235 Free PMC article.
To demonstrate the robustness and versatility of the approach, we have tested it on a variety of legged platforms, including two humanoid robots (the Boston Dynamics Atlas and NASA Valkyrie) and two dynamic quadruped robots (IIT HyQ and ANYbotics ANYmal) for more than 2 h …
To demonstrate the robustness and versatility of the approach, we have tested it on a variety of legged platforms, including two humanoid ro …