Search Page

1

Cite

Share

Microtubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night.

Oláh J, Lehotzky A, Szunyogh S, Szénási T, Orosz F, Ovádi J. Oláh J, et al. Among authors: lehotzky a. Cells. 2020 Feb 4;9(2):357. doi: 10.3390/cells9020357. Cells. 2020. PMID: 32033023 Free PMC article. Review.

Cite

Share

2

Cite

Share

Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.

Oláh J, Lehotzky A, Szénási T, Ovádi J. Oláh J, et al. Among authors: lehotzky a. Cells. 2021 Oct 27;10(11):2909. doi: 10.3390/cells10112909. Cells. 2021. PMID: 34831132 Free PMC article.

Cite

Share

3

Cite

Share

Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models.

Lehotzky A, Oláh J, Fekete JT, Szénási T, Szabó E, Győrffy B, Várady G, Ovádi J. Lehotzky A, et al. Front Mol Biosci. 2021 May 18;8:666026. doi: 10.3389/fmolb.2021.666026. eCollection 2021. Front Mol Biosci. 2021. PMID: 34084775 Free PMC article.

Cite

Share

4

Cite

Share

Structure-Based Development of an Affinity Probe for Sirtuin 2.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Schiedel M, et al. Among authors: lehotzky a. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. doi: 10.1002/anie.201509843. Epub 2016 Jan 8. Angew Chem Int Ed Engl. 2016. PMID: 26748890

Cite

Share

5

Cite

Share

HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.

Schiedel M, Lehotzky A, Szunyogh S, Oláh J, Hammelmann S, Wössner N, Robaa D, Einsle O, Sippl W, Ovádi J, Jung M. Schiedel M, et al. Among authors: lehotzky a. Chembiochem. 2020 Dec 1;21(23):3371-3376. doi: 10.1002/cbic.202000351. Epub 2020 Aug 27. Chembiochem. 2020. PMID: 32672888 Free PMC article.

Cite

Share

6

Cite

Share

Challenges in Discovering Drugs That Target the Protein-Protein Interactions of Disordered Proteins.

Oláh J, Szénási T, Lehotzky A, Norris V, Ovádi J. Oláh J, et al. Among authors: lehotzky a. Int J Mol Sci. 2022 Jan 28;23(3):1550. doi: 10.3390/ijms23031550. Int J Mol Sci. 2022. PMID: 35163473 Free PMC article. Review.

Cite

Share

7

Cite

Share

Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.

Oláh J, Szunyogh S, Szénási T, Szaniszló T, Szabó A, Lehotzky A, Berki T, Nyitray L, Ovádi J. Oláh J, et al. Among authors: lehotzky a. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118556. doi: 10.1016/j.bbamcr.2019.118556. Epub 2019 Sep 7. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31505170 Free article.

Cite

Share

8

Cite

Share

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Schiedel M, et al. Among authors: lehotzky a. J Med Chem. 2016 Feb 25;59(4):1599-612. doi: 10.1021/acs.jmedchem.5b01517. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26696402 Free article.

Cite

Share

9

Cite

Share

New chemical tools for probing activity and inhibition of the NAD⁺-dependent lysine deacylase sirtuin 2.

Swyter S, Schiedel M, Monaldi D, Szunyogh S, Lehotzky A, Rumpf T, Ovádi J, Sippl W, Jung M. Swyter S, et al. Among authors: lehotzky a. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170083. doi: 10.1098/rstb.2017.0083. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685963 Free PMC article.

Cite

Share

10

Cite

Share

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: lehotzky a. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.

Cite

Share