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The following term was not found in PubMed: Rivza
Page 1
The muscle-intervertebral disc interaction mediated by L-BAIBA modulates extracellular matrix homeostasis and PANoptosis in nucleus pulposus cells.
Qin T, Shi M, Zhang C, Wu J, Huang Z, Zhang X, Li S, Wu Y, Han W, Gao B, Xu K, Jin S, Ye W. Qin T, et al. Exp Mol Med. 2024 Nov;56(11):2503-2518. doi: 10.1038/s12276-024-01345-5. Epub 2024 Nov 7. Exp Mol Med. 2024. PMID: 39511429 Free PMC article.
Our study demonstrated that exercise significantly elevates BAIBA levels in skeletal muscle, plasma, and nucleus pulposus (NP) tissues. Moreover, exercise enhances extracellular matrix (ECM) synthesis in NP tissues and upregulates L-BAIBA synthase in skeletal muscle …
Our study demonstrated that exercise significantly elevates BAIBA levels in skeletal muscle, plasma, and nucleus pulposus (NP) tissue …
Exercise suppresses osteoclastogenesis by increasing the secretion of muscle-derived L-β-aminoisobutyric acid.
Huang ZW, Yu YP, He XR, Chen YB, Xiang X, Li HZ, Cai ZH, Zhang JY, Wu DZ, Zhu GZ, Gao JW, Cai GX, Yang S, Tu C, Zhong ZM. Huang ZW, et al. J Sport Health Sci. 2025 Aug 9;15:101077. doi: 10.1016/j.jshs.2025.101077. Online ahead of print. J Sport Health Sci. 2025. PMID: 40789518 Free PMC article.
However, the role of exercise-induced L-BAIBA secretion in PMOP remains unclear. In this study, we aimed to evaluate the therapeutic efficacy of L-BAIBA in mitigating bone loss using an ovariectomized (OVX) mouse exercise-induced model. ...RESULTS: Exercise increase …
However, the role of exercise-induced L-BAIBA secretion in PMOP remains unclear. In this study, we aimed to evaluate the therapeutic …
Both enantiomers of beta-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes.
Sakamoto E, Kitase Y, Fitt AJ, Zhu Z, Awad K, Brotto M, White KE, Welc SS, Bergwitz C, Bonewald LF. Sakamoto E, et al. Cell Rep. 2024 Jul 23;43(7):114397. doi: 10.1016/j.celrep.2024.114397. Epub 2024 Jun 25. Cell Rep. 2024. PMID: 38935499 Free PMC article.
Exercise in mice increased fibroblast growth factor 23 (FGF23), urine phosphate, and the muscle metabolite L-beta-aminoisobutyric acid (L-BAIBA), suggesting that L-BAIBA may play a role in phosphate metabolism. Here, we show that L-BAIBA increases in serum wi …
Exercise in mice increased fibroblast growth factor 23 (FGF23), urine phosphate, and the muscle metabolite L-beta-aminoisobutyric acid (L- …
Myokines: metabolic regulation in obesity and type 2 diabetes.
Chen ZT, Weng ZX, Lin JD, Meng ZX. Chen ZT, et al. Life Metab. 2024 Mar 2;3(3):loae006. doi: 10.1093/lifemeta/loae006. eCollection 2024 Jun. Life Metab. 2024. PMID: 39872377 Free PMC article. Review.
In this review, we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades, namely interleukin 6 (IL-6), irisin, myostatin (MSTN), growth differentiation factor 11 (GDF11), fibroblast growth factor 21 (FGF21), …
In this review, we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two de …
Bone-Muscle Mutual Interactions.
Lara-Castillo N, Johnson ML. Lara-Castillo N, et al. Curr Osteoporos Rep. 2020 Aug;18(4):408-421. doi: 10.1007/s11914-020-00602-6. Curr Osteoporos Rep. 2020. PMID: 32519283 Free PMC article. Review.
These include muscle factors such as myostatin, Irisin, BAIBA, IL-6, and the IGF family and the bone factors FGF-23, Wnt1 and Wnt3a, PGE2, FGF9, RANKL, osteocalcin, and sclerostin. ...
These include muscle factors such as myostatin, Irisin, BAIBA, IL-6, and the IGF family and the bone factors FGF-23, Wnt1 and Wnt3a, …
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review.
Gonzalez-Gil AM, Elizondo-Montemayor L. Gonzalez-Gil AM, et al. Nutrients. 2020 Jun 26;12(6):1899. doi: 10.3390/nu12061899. Nutrients. 2020. PMID: 32604889 Free PMC article. Review.
In this review, we explain the potential role of these exercise-inducible factors, namely myokines, such as irisin, IL-6, IL-15, METRNL, BAIBA, and myostatin, and hepatokines, in particular selenoprotein P, fetuin A, FGF21, ANGPTL4, and follistatin. ...
In this review, we explain the potential role of these exercise-inducible factors, namely myokines, such as irisin, IL-6, IL-15, METRNL, …
L-beta-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice.
Vallejo JA, Kitase Y, Ganesh T, Dallas M, Xie Y, Moore DS, Johnson ML, Bonewald LF, Wacker MJ. Vallejo JA, et al. Aging (Albany NY). 2025 Oct 1;17(10):2475-2499. doi: 10.18632/aging.206325. Epub 2025 Oct 1. Aging (Albany NY). 2025. PMID: 41045489 Free PMC article.
To investigate this hypothesis, we subjected 12-month-old (as a model of middle-age) male C57BL6 mice to voluntary wheel running (VWR) with L-BAIBA (100mg/kg/day) (VWR+L-BAIBA), VWR alone, L-BAIBA alone, or none (CTRL) for three months. ...In EDL muscle, VWR …
To investigate this hypothesis, we subjected 12-month-old (as a model of middle-age) male C57BL6 mice to voluntary wheel running (VWR) with …
Oct-B: A derivative of L-BAIBA significantly alleviating high-fat diet-induced obesity in mice.
Wang J, Wei S, Guo J, Xie X, Sun W, Zhao S, Meng J, Wang F, Wang J, Rong R, Jiang P. Wang J, et al. Biochem Biophys Res Commun. 2024 Nov 19;734:150739. doi: 10.1016/j.bbrc.2024.150739. Epub 2024 Sep 25. Biochem Biophys Res Commun. 2024. PMID: 39357338 Free article.
Supplementation with (S)-beta-aminoisobutyric acid (L-BAIBA) has shown potential in preventing obesity and related metabolic disorders induced by high-fat diets. However, developing effective and low-toxicity BAIBA derivatives remains a challenging yet promising fie …
Supplementation with (S)-beta-aminoisobutyric acid (L-BAIBA) has shown potential in preventing obesity and related metabolic disorder …
Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats.
Aktaş İ, Mehmet Gür F. Aktaş İ, et al. Biotech Histochem. 2022 Jan;97(1):67-76. doi: 10.1080/10520295.2021.1949041. Epub 2021 Jul 19. Biotech Histochem. 2022. PMID: 34281431
Pathological changes caused by DM were reduced significantly in the STZ + TQ, STZ + BAIBA and STZ + TQ + BAIBA groups. The protective effect of BAIBA was greater than for TQ; the greatest protective effect was observed following combined use of TQ + BAIBA …
Pathological changes caused by DM were reduced significantly in the STZ + TQ, STZ + BAIBA and STZ + TQ + BAIBA groups. The pro …
beta-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes.
Audzeyenka I, Szrejder M, Rogacka D, Angielski S, Saleem MA, Piwkowska A. Audzeyenka I, et al. Sci Rep. 2023 Jan 14;13(1):766. doi: 10.1038/s41598-023-27914-8. Sci Rep. 2023. PMID: 36641502 Free PMC article.
BAIBA has been reported to be involved in regulating mitochondrial dynamics, but unknown is whether BAIBA influences podocyte bioenergetics. The present study showed that human podocytes express the BAIBA receptor, Mas-related G protein-coupled receptor type …
BAIBA has been reported to be involved in regulating mitochondrial dynamics, but unknown is whether BAIBA influences podocyte …
159 results