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Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches.

Szilágyi K, Hajdú I, Flachner B, Lőrincz Z, Balczer J, Gál P, Závodszky P, Pirli C, Balogh B, Mándity IM, Cseh S, Dormán G. Szilágyi K, et al. Among authors: flachner b. Molecules. 2019 Oct 9;24(20):3641. doi: 10.3390/molecules24203641. Molecules. 2019. PMID: 31600984 Free PMC article.

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Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix flexibility.

Kovári Z, Flachner B, Náray-Szabó G, Vas M. Kovári Z, et al. Among authors: flachner b. Biochemistry. 2002 Jul 16;41(28):8796-806. doi: 10.1021/bi020210j. Biochemistry. 2002. PMID: 12102622

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Role of phosphate chain mobility of MgATP in completing the 3-phosphoglycerate kinase catalytic site: binding, kinetic, and crystallographic studies with ATP and MgATP.

Flachner B, Kovári Z, Varga A, Gugolya Z, Vonderviszt F, Náray-Szabó G, Vas M. Flachner B, et al. Biochemistry. 2004 Mar 30;43(12):3436-49. doi: 10.1021/bi035022n. Biochemistry. 2004. PMID: 15035615

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A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts.

Somogyi M, Szimler T, Baksa A, Végh BM, Bakos T, Paréj K, Ádám C, Zsigmond Á, Megyeri M, Flachner B, Sajó R, Gráczer É, Závodszky P, Hajdú I, Beinrohr L. Somogyi M, et al. Among authors: flachner b. PLoS One. 2019 Dec 30;14(12):e0227110. doi: 10.1371/journal.pone.0227110. eCollection 2019. PLoS One. 2019. PMID: 31887188 Free PMC article.

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Rapid Identification of Potential Drug Candidates from Multi-Million Compounds' Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening.

Szilágyi K, Flachner B, Hajdú I, Szaszkó M, Dobi K, Lőrincz Z, Cseh S, Dormán G. Szilágyi K, et al. Among authors: flachner b. Molecules. 2021 Sep 15;26(18):5593. doi: 10.3390/molecules26185593. Molecules. 2021. PMID: 34577064 Free PMC article. Review.

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Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments.

Kelemen ÁA, Kiss R, Ferenczy GG, Kovács L, Flachner B, Lőrincz Z, Keserű GM. Kelemen ÁA, et al. Among authors: flachner b. J Chem Inf Model. 2016 Feb 22;56(2):412-22. doi: 10.1021/acs.jcim.5b00598. Epub 2016 Jan 29. J Chem Inf Model. 2016. PMID: 26760056

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Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening.

Szaszkó M, Hajdú I, Flachner B, Dobi K, Magyar C, Simon I, Lőrincz Z, Kapui Z, Pázmány T, Cseh S, Dormán G. Szaszkó M, et al. Among authors: flachner b. Mol Divers. 2017 Feb;21(1):175-186. doi: 10.1007/s11030-016-9717-4. Epub 2017 Jan 9. Mol Divers. 2017. PMID: 28070724

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Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase.

Varga A, Szabó J, Flachner B, Gugolya Z, Vonderviszt F, Závodszky P, Vas M. Varga A, et al. Among authors: flachner b. FEBS Lett. 2009 Nov 19;583(22):3660-4. doi: 10.1016/j.febslet.2009.10.048. Epub 2009 Oct 23. FEBS Lett. 2009. PMID: 19854185 Free article.

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Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase.

Szabó J, Varga A, Flachner B, Konarev PV, Svergun DI, Závodszky P, Vas M. Szabó J, et al. Among authors: flachner b. FEBS Lett. 2008 Apr 16;582(9):1335-40. doi: 10.1016/j.febslet.2008.03.016. Epub 2008 Mar 20. FEBS Lett. 2008. PMID: 18358841 Free article.

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A chemocentric approach to the identification of cancer targets.

Flachner B, Lörincz Z, Carotti A, Nicolotti O, Kuchipudi P, Remez N, Sanz F, Tóvári J, Szabó MJ, Bertók B, Cseh S, Mestres J, Dormán G. Flachner B, et al. PLoS One. 2012;7(4):e35582. doi: 10.1371/journal.pone.0035582. Epub 2012 Apr 25. PLoS One. 2012. PMID: 22558171 Free PMC article.

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