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Page 1
Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism.
Biagioli M, Di Giorgio C, Massa C, Marchianò S, Bellini R, Bordoni M, Urbani G, Roselli R, Lachi G, Morretta E, Piaz FD, Charlier B, Fiorillo B, Catalanotti B, Cari L, Nocentini G, Ricci P, Distrutti E, Festa C, Sepe V, Zampella A, Monti MC, Fiorucci S. Biagioli M, et al. Among authors: fiorillo b. Biomed Pharmacother. 2024 Dec;181:117731. doi: 10.1016/j.biopha.2024.117731. Epub 2024 Dec 9. Biomed Pharmacother. 2024. PMID: 39657506 Free article.
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Delle Donne R, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-Quesada O, Stefan E, Kwiatkowski M, van Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A. Senatore E, et al. Among authors: fiorillo b. EMBO J. 2021 May 17;40(10):e106503. doi: 10.15252/embj.2020106503. Epub 2021 May 2. EMBO J. 2021. PMID: 33934390 Free PMC article.
Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.
Morgillo CM, Lupia A, Deplano A, Pirone L, Fiorillo B, Pedone E, Luque FJ, Onnis V, Moraca F, Catalanotti B. Morgillo CM, et al. Among authors: fiorillo b. Int J Mol Sci. 2022 Dec 7;23(24):15502. doi: 10.3390/ijms232415502. Int J Mol Sci. 2022. PMID: 36555144 Free PMC article.
Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR.
Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, Wacker D. Zilberg G, et al. Among authors: fiorillo b. bioRxiv [Preprint]. 2023 Oct 7:2023.10.05.561100. doi: 10.1101/2023.10.05.561100. bioRxiv. 2023. Update in: Sci Adv. 2024 Apr 19;10(16):eadk4855. doi: 10.1126/sciadv.adk4855. PMID: 37986777 Free PMC article. Updated. Preprint.
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Biagioli M, Marchianò S, di Giorgio C, Roselli R, Bordoni M, Bellini R, Fiorillo B, Sepe V, Catalanotti B, Cassiano C, Monti MC, Distrutti E, Zampella A, Fiorucci S. Biagioli M, et al. Among authors: fiorillo b. Hepatology. 2023 Jul 1;78(1):26-44. doi: 10.1002/hep.32787. Epub 2022 Oct 12. Hepatology. 2023. PMID: 36107019
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders.
Fiorillo B, Roselli R, Finamore C, Biagioli M, di Giorgio C, Bordoni M, Conflitti P, Marchianò S, Bellini R, Rapacciuolo P, Cassiano C, Limongelli V, Sepe V, Catalanotti B, Fiorucci S, Zampella A. Fiorillo B, et al. ACS Omega. 2023 Jan 31;8(6):5983-5994. doi: 10.1021/acsomega.2c07907. eCollection 2023 Feb 14. ACS Omega. 2023. PMID: 36816679 Free PMC article.
Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis.
Rapacciuolo P, Finamore C, Giorgio CD, Fiorillo B, Massa C, Urbani G, Marchianò S, Bordoni M, Cassiano C, Morretta E, Spinelli L, Lupia A, Moraca F, Biagioli M, Sepe V, Monti MC, Catalanotti B, Fiorucci S, Zampella A. Rapacciuolo P, et al. Among authors: fiorillo b. J Med Chem. 2024 Oct 24;67(20):18334-18355. doi: 10.1021/acs.jmedchem.4c01651. Epub 2024 Oct 9. J Med Chem. 2024. PMID: 39382988
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