Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1933 1
1944 1
1949 2
1950 7
1951 5
1952 2
1953 1
1954 3
1955 17
1956 21
1957 21
1958 23
1959 14
1960 9
1961 7
1962 21
1963 61
1964 42
1965 28
1966 38
1967 16
1968 34
1969 24
1970 31
1971 32
1972 36
1973 43
1974 32
1975 56
1976 61
1977 60
1978 63
1979 94
1980 98
1981 88
1982 97
1983 135
1984 110
1985 135
1986 153
1987 183
1988 205
1989 298
1990 404
1991 345
1992 511
1993 507
1994 570
1995 576
1996 1188
1997 2204
1998 1963
1999 3067
2000 4484
2001 6535
2002 7634
2003 8689
2004 9123
2005 9439
2006 8601
2007 9706
2008 10504
2009 11171
2010 12095
2011 11963
2012 12002
2013 13282
2014 16120
2015 18333
2016 19801
2017 19990
2018 20552
2019 20872
2020 23454
2021 25766
2022 24125
2023 22176
2024 22888
2025 23599
2026 12249

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

369,927 results

Results by year

Filters applied: . Clear all
The following term was not found in PubMed: Bon-Jae
Page 1
Ku limits RNA-induced innate immunity to allow Alu expansion in primates.
Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild-Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S. Zhu Y, et al. Nature. 2025 Jul;643(8071):562-571. doi: 10.1038/s41586-025-09104-w. Epub 2025 May 15. Nature. 2025. PMID: 40373806 Free PMC article.
Although Ku can bind to double-stranded RNA (dsRNA)(2) and trap mutated DNA-PKcs on ribosomal RNA(3,4), the physiological role of the Ku-RNA interaction in otherwise wild-type cells remains unclear. Notably, Ku is dispensable for mouse development(5,6) but is …
Although Ku can bind to double-stranded RNA (dsRNA)(2) and trap mutated DNA-PKcs on ribosomal RNA(3,4), the physiological role of the …
Kurarinone regulates Th17/Treg balance and ameliorates autoimmune uveitis via Rac1 inhibition.
Gu C, Liu Y, Lv J, Zhang C, Huang Z, Jiang Q, Gao Y, Tao T, Su Y, Chen B, Jia R, Liu X, Su W. Gu C, et al. J Adv Res. 2025 Mar;69:381-398. doi: 10.1016/j.jare.2024.03.013. Epub 2024 Mar 24. J Adv Res. 2025. PMID: 38522752 Free PMC article.
OBJECTIVE: We aimed to investigate the effects of KU on AU and its modulatory mechanisms. METHODS: We used an experimental autoimmune uveitis (EAU) animal model and characterized the comprehensive immune landscape of KU-treated EAU mice using single-cell RNA sequenc …
OBJECTIVE: We aimed to investigate the effects of KU on AU and its modulatory mechanisms. METHODS: We used an experimental autoimmune …
Restriction of Ku translocation protects telomere ends.
Mattarocci S, Baconnais S, Roisné-Hamelin F, Pobiega S, Alibert O, Morin V, Deshayes A, Veaute X, Ropars V, Chevreuil M, Mehringer J, Busso D, Mazon G, Fernandez Varela P, Le Cam É, Charbonnier JB, Cuniasse P, Marcand S. Mattarocci S, et al. Nat Commun. 2025 Jul 24;16(1):6824. doi: 10.1038/s41467-025-61864-1. Nat Commun. 2025. PMID: 40707444 Free PMC article.
Here, we find that Rap1 directly inhibits Ku's NHEJ function at telomeres. A single Rap1 molecule near a double-stand break suppresses NHEJ without displacing Ku in cells. Furthermore, Rap1 and Ku form a complex on short DNA duplexes in vitro. Cryo-EM shows R …
Here, we find that Rap1 directly inhibits Ku's NHEJ function at telomeres. A single Rap1 molecule near a double-stand break suppresse …
Anti-Ku-positive juvenile dermatomyositis.
Cotter C, Rudd E, Williamson E, Philippidou M, Tewari A. Cotter C, et al. Clin Exp Dermatol. 2022 Feb;47(2):425-427. doi: 10.1111/ced.14937. Epub 2021 Oct 8. Clin Exp Dermatol. 2022. PMID: 34528293 No abstract available.
Identification of the main barriers to Ku accumulation in chromatin.
Bossaert M, Moreno AT, Peixoto A, Pillaire MJ, Chanut P, Frit P, Calsou P, Loparo JJ, Britton S. Bossaert M, et al. Cell Rep. 2024 Aug 27;43(8):114538. doi: 10.1016/j.celrep.2024.114538. Epub 2024 Jul 25. Cell Rep. 2024. PMID: 39058590 Free PMC article.
Repair of DNA double-strand breaks by the non-homologous end-joining pathway is initiated by the binding of Ku to DNA ends. Multiple Ku proteins load onto linear DNAs in vitro. However, in cells, Ku loading is limited to 1-2 molecules per DNA end. ...Here, w …
Repair of DNA double-strand breaks by the non-homologous end-joining pathway is initiated by the binding of Ku to DNA ends. Multiple …
The pendulum of the Ku-Ku clock.
Shibata A, Jeggo P, Löbrich M. Shibata A, et al. DNA Repair (Amst). 2018 Nov;71:164-171. doi: 10.1016/j.dnarep.2018.08.020. Epub 2018 Aug 23. DNA Repair (Amst). 2018. PMID: 30177438 Free article. Review.
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our review reveals that Ku plays an active role in determining pathway choice and exposes similarities yet distinctions in the progressi …
Emerging evidence has suggested that Ku is the first protein binding most, if not all, DSBs, and creates a block to resection. ...Our …
[Anti-Ku antibodies].
Suwa A, Mimori T. Suwa A, et al. Nihon Rinsho. 1999 Nov;57 Suppl:450-2. Nihon Rinsho. 1999. PMID: 10635880 Review. Japanese. No abstract available.
The Multifaceted Roles of Ku70/80.
Zahid S, Seif El Dahan M, Iehl F, Fernandez-Varela P, Le Du MH, Ropars V, Charbonnier JB. Zahid S, et al. Int J Mol Sci. 2021 Apr 16;22(8):4134. doi: 10.3390/ijms22084134. Int J Mol Sci. 2021. PMID: 33923616 Free PMC article. Review.
Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, and genome editing. The heterodimer Ku70/80 (Ku) is a central actor of the c-NHEJ as it rapidly recognizes broken DNA ends in the cell …
Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, an …
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB. Kefala Stavridi A, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11732-11747. doi: 10.1093/nar/gkad863. Nucleic Acids Res. 2023. PMID: 37870477 Free PMC article.
The metabolite inositol-hexaphosphate (IP6) stimulates c-NHEJ by interacting with the Ku70-Ku80 heterodimer (Ku). We report cryo-EM structures of apo- and DNA-bound Ku in complex with IP6, at 3.5 A and 2.74 A resolutions respectively, and an X-ray crystallography st …
The metabolite inositol-hexaphosphate (IP6) stimulates c-NHEJ by interacting with the Ku70-Ku80 heterodimer (Ku). We report cryo-EM s …
Plugged into the Ku-DNA hub: The NHEJ network.
Frit P, Ropars V, Modesti M, Charbonnier JB, Calsou P. Frit P, et al. Prog Biophys Mol Biol. 2019 Oct;147:62-76. doi: 10.1016/j.pbiomolbio.2019.03.001. Epub 2019 Mar 6. Prog Biophys Mol Biol. 2019. PMID: 30851288 Review.
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on protein …
Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized p …
369,927 results
You have reached the last available page of results. Please see the User Guide for more information.