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A reversible broad-spectrum antiviral targets the human V-ATPase VO domain.
Pérez-Vargas J, Bautista-Sánchez D, Oot RA, Thompson CAH, Williams DE, Presley L, Gordon DG, Schulz AL, Knight K, Ennis S, Scheibner D, Krampert L, McArthur SJ, Kaushik N, Olver S, Gao G, Park JB, Villanueva I, Gagnon K, Nowakowski A, Brown CM, Chew LH, Knock E, Hetrick B, Diederich S, Roh SH, Niikura M, Warner B, Wilkens S, Andersen RJ, Jean F. Pérez-Vargas J, et al. Among authors: hetrick b. Res Sq [Preprint]. 2026 Jun 3:rs.3.rs-9889115. doi: 10.21203/rs.3.rs-9889115/v1. Res Sq. 2026. PMID: 42282011 Free PMC article. Preprint.
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
Presley L, Pérez-Vargas J, Saintigny A, Villanueva I, Ho M, Fone J, Brinsden L, Kaushik N, Olver S, Thompson CAH, Bautista-Sánchez D, Ennis S, Chen M, McCallum M, Brown JT, Ferková S, Hetrick B, Veesler D, Leduc R, Niikura M, Boudreault PL, Warner B, Jean F. Presley L, et al. Among authors: hetrick b. Emerg Microbes Infect. 2026 Dec;15(1):2616944. doi: 10.1080/22221751.2026.2616944. Epub 2026 Jan 30. Emerg Microbes Infect. 2026. PMID: 41612887 Free PMC article.
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