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Showing results for brain kittler
Your search for Brian Kittler retrieved no results
Mitochondria at the neuronal presynapse in health and disease.
Devine MJ, Kittler JT. Devine MJ, et al. Nat Rev Neurosci. 2018 Jan 19;19(2):63-80. doi: 10.1038/nrn.2017.170. Nat Rev Neurosci. 2018. PMID: 29348666 Review.
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, this communication requires energy and generates large fluctuations in calcium concentrations. ...
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, t …
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate …
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's
Cognition in ring-tailed lemurs.
Kittler K, Schnoell AV, Fichtel C. Kittler K, et al. Folia Primatol (Basel). 2015;86(1-2):106-116. doi: 10.1159/000368669. Epub 2015 May 19. Folia Primatol (Basel). 2015. PMID: 26022306 Free article. Review.
Compared to haplorhine primates, lemurs have relatively smaller brains and reduced abilities to solve problems in the technical and social domain. ...
Compared to haplorhine primates, lemurs have relatively smaller brains and reduced abilities to solve problems in the technical and s …
Acute In Vivo Expression of Recombinant Proteins in Rat Brain Using Sindbis Virus.
Marie H, Malenka RC. Marie H, et al. In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 12. In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 12. PMID: 21204479 Free Books & Documents. Review.
More recently, the expression of heterologous proteins in organotypic brain slices and dissociated neuronal cultures has become another valuable method to study protein function in neurons. ...Cell-based assays on the infected neurons can then be performed using well-estab …
More recently, the expression of heterologous proteins in organotypic brain slices and dissociated neuronal cultures has become anoth …
Mitochondrial roles of the psychiatric disease risk factor DISC1.
Norkett R, Modi S, Kittler JT. Norkett R, et al. Schizophr Res. 2017 Sep;187:47-54. doi: 10.1016/j.schres.2016.12.025. Epub 2017 Jan 10. Schizophr Res. 2017. PMID: 28087269 Review.
Ion transport during neuronal signalling utilizes the majority of the brain's energy supply. Mitochondria are key sites for energy provision through ATP synthesis and play other important roles including calcium buffering. ...
Ion transport during neuronal signalling utilizes the majority of the brain's energy supply. Mitochondria are key sites for en …
The cell biology of synaptic inhibition in health and disease.
Smith KR, Kittler JT. Smith KR, et al. Curr Opin Neurobiol. 2010 Oct;20(5):550-6. doi: 10.1016/j.conb.2010.06.001. Epub 2010 Jul 23. Curr Opin Neurobiol. 2010. PMID: 20650630 Review.
Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA( …
Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in …
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT. Halff EF, et al. Cell Rep. 2019 Nov 26;29(9):2599-2607.e6. doi: 10.1016/j.celrep.2019.10.096. Cell Rep. 2019. PMID: 31775031 Free PMC article.
GABA(A) receptors mediate fast inhibitory transmission in the brain, and their number can be rapidly up- or downregulated to alter synaptic strength. ...Here, we show that neuroligin-2, when internalized to endosomes, co-localizes with SNX27, a brain-enriched cargo- …
GABA(A) receptors mediate fast inhibitory transmission in the brain, and their number can be rapidly up- or downregulated to alter sy …
Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses.
MacAskill AF, Atkin TA, Kittler JT. MacAskill AF, et al. Eur J Neurosci. 2010 Jul;32(2):231-40. doi: 10.1111/j.1460-9568.2010.07345.x. Eur J Neurosci. 2010. PMID: 20946113 Review.
Neuronal postsynaptic currents consume most of the brain's energy supply. Delineating how neurons control the distribution, morphology and function of the energy-producing mitochondria that fuel synaptic communication is therefore important for our understanding of …
Neuronal postsynaptic currents consume most of the brain's energy supply. Delineating how neurons control the distribution, mo …
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.
Jovanovic JN, Thomas P, Kittler JT, Smart TG, Moss SJ. Jovanovic JN, et al. J Neurosci. 2004 Jan 14;24(2):522-30. doi: 10.1523/JNEUROSCI.3606-03.2004. J Neurosci. 2004. PMID: 14724252 Free PMC article.
The efficacy of GABAergic synaptic inhibition is a principal factor in controlling neuronal activity. We demonstrate here that brain-derived neurotrophic factor modulates the activity of GABA(A) receptors, the main sites of fast synaptic inhibition in the brain, wit …
The efficacy of GABAergic synaptic inhibition is a principal factor in controlling neuronal activity. We demonstrate here that brain- …
77 results