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Showing results for brain Smerdon
Your search for Brian Smerdon retrieved no results
Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence for and Against.
Eggleton P, Smerdon GR, Holley JE, Gutowski NJ. Eggleton P, et al. Adv Exp Med Biol. 2017;958:11-27. doi: 10.1007/978-3-319-47861-6_2. Adv Exp Med Biol. 2017. PMID: 28093705 Review.
Multiple sclerosis (MS) is normally considered a chronic inflammatory disease of the central nervous system (CNS), where T-cells breaching the blood brain barrier react against proteins of the axonal myelin sheaths, leading to focal plaques and demyelination in the brai
Multiple sclerosis (MS) is normally considered a chronic inflammatory disease of the central nervous system (CNS), where T-cells breaching t …
Human Parechovirus 3 in Infants: Expanding Our Knowledge of Adverse Outcomes.
Joseph L, May M, Thomas M, Smerdon C, Tozer S, Bialasiewicz S, McKenna R, Sargent P, Kynaston A, Heney C, Clark JE. Joseph L, et al. Pediatr Infect Dis J. 2019 Jan;38(1):1-5. doi: 10.1097/INF.0000000000002136. Pediatr Infect Dis J. 2019. PMID: 30204658
Of 15 children with initially abnormal brain magnetic resonance imaging, 47% (n = 7) had neurodevelopmental concerns, the remainder had normal development at follow-up between 6 and 15 months of age. ...
Of 15 children with initially abnormal brain magnetic resonance imaging, 47% (n = 7) had neurodevelopmental concerns, the remainder h …
The legendary contributions of Thomas Willis (1621-1675): the arterial circle and beyond.
Rengachary SS, Xavier A, Manjila S, Smerdon U, Parker B, Hadwan S, Guthikonda M. Rengachary SS, et al. J Neurosurg. 2008 Oct;109(4):765-75. doi: 10.3171/JNS/2008/109/10/0765. J Neurosurg. 2008. PMID: 18826368
He has also described several disease entities and named many brain structures. Willis' accomplishments in comparative anatomy and understanding the pathophysiology of various diseases through original multidisciplinary experimental work in a clinical setting reveal that h …
He has also described several disease entities and named many brain structures. Willis' accomplishments in comparative anatomy and un …
Engagement of people with multiple sclerosis to enhance research into the physiological effect of hyperbaric oxygen therapy.
Moore L, Eggleton P, Smerdon G, Newcombe J, Holley JE, Gutowski NJ, Smallwood M. Moore L, et al. Mult Scler Relat Disord. 2020 Apr 29;43:102084. doi: 10.1016/j.msard.2020.102084. Online ahead of print. Mult Scler Relat Disord. 2020. PMID: 32442882
In a laboratory-based study human brain endothelial cells were exposed in vitro to 152 mmHg O(2) for 60 min with and without pressure, as this equates to 20% O(2) achievable via hyperbarics, which was then replicated at atmospheric pressure. A significant reduction in endo …
In a laboratory-based study human brain endothelial cells were exposed in vitro to 152 mmHg O(2) for 60 min with and without pressure …
The oxidative DNA lesion 8,5'-(S)-cyclo-2'-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells.
Brooks PJ, Wise DS, Berry DA, Kosmoski JV, Smerdon MJ, Somers RL, Mackie H, Spoonde AY, Ackerman EJ, Coleman K, Tarone RE, Robbins JH. Brooks PJ, et al. J Biol Chem. 2000 Jul 21;275(29):22355-62. doi: 10.1074/jbc.M002259200. J Biol Chem. 2000. PMID: 10801836 Free article.
Searching for such a lesion, we developed a synthesis for 8,5'-(S)-cyclo-2'-deoxyadenosine (cyclo-dA), a free radical-induced bulky lesion, and incorporated it into DNA to test its repair in mammalian cell extracts and living cells. Using extracts of normal and mutant Chin …
Searching for such a lesion, we developed a synthesis for 8,5'-(S)-cyclo-2'-deoxyadenosine (cyclo-dA), a free radical-induced bulky l …
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